A5070369147- Cancer, Hypoxia, and Metabolism
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Epigenetics and DNA Methylation
- Cancer Treatment and Pharmacology
- Cytomegalovirus and herpesvirus research
- Hematopoietic Stem Cell Transplantation
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- CAR-T cell therapy research
- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- Histone Deacetylase Inhibitors Research
- Plant Diversity and Evolution
- Diabetes Management and Research
- Hedgehog Signaling Pathway Studies
- Climate change impacts on agriculture
- PI3K/AKT/mTOR signaling in cancer
- Polyomavirus and related diseases
- Renal Transplantation Outcomes and Treatments
- Computational Drug Discovery Methods
- Berberine and alkaloids research
University of Chinese Academy of Sciences
2019-2025
Chinese Academy of Sciences
2015-2025
Institute of Genetics and Developmental Biology
2025
Xishuangbanna Tropical Botanical Garden
2024
Nanjing Medical University
2021-2024
Zhongda Hospital Southeast University
2010-2024
Jiangsu Province Hospital
2022-2024
Wuhan Sixth Hospital
2022-2024
Second Affiliated Hospital of Zhejiang University
2024
Yunnan University
2024
Abstract One of the biggest hurdles for development metabolism-targeted therapies is to identify responsive tumor subsets. However, metabolic vulnerabilities most human cancers remain unclear. Establishing link between signatures and oncogenic alterations receptor tyrosine kinases (RTK), well-defined cancer genotypes, may precisely direct intervention a broad patient population. By integrating metabolomics transcriptomics, we herein show that RTK activation causes distinct preference....
We outline a framework for elucidating tumor genetic complexity through multidimensional protein-protein interaction maps and apply it to enhancing our understanding of head neck squamous cell carcinoma. This network uncovers 771 interactions from cancer noncancerous states, including WT mutant protein isoforms. Prioritization cancer-enriched reveals previously unidentified association the fibroblast growth factor receptor tyrosine kinase 3 with Daple, guanine-nucleotide exchange factor,...
Abstract Pyruvate dehydrogenase kinase PDK1 is a metabolic enzyme responsible for switching glucose metabolism from mitochondrial oxidation to aerobic glycolysis in cancer cells, general hallmark of malignancy termed the Warburg effect. Herein we report identification JX06 as selective covalent inhibitor cells. forms disulfide bond with thiol group conserved cysteine residue (C240) based on recognition hydrophobic pocket adjacent ATP enzyme. Our investigations mechanism suggested that...
Introduction Canopy species need to shift their ecological adaptation improve light and water resources utilization, the study of intraspecific variations in plant leaf functional traits based at individual scale is great significance for evaluating adaptability climate change. Methods In this study, we evaluate how giant trees relate spatial niche specialization along a vertical gradient. We sampled tropical flagship Parashorea chinensis around 60 meters tall divided crowns into three...
Purpose . To evaluate the efficacy and safety of epithelium-on corneal collagen cross-linking (CXL) using a multifactorial approach to achieve proper stromal riboflavin saturation. Methods This non-randomized retrospective study comprised 61 eyes with progressive keratoconus treated CXL. Chemical epithelial penetration enhancement (benzalkonium chloride-containing local medication hypotonic solution), mechanical disruption superficial epithelium, prolongation riboflavin-induction time until...
Glycolytic enzymes are known to play pivotal roles in cancer cell survival, yet their molecular mechanisms remain poorly understood. Phosphoglycerate mutase 1 (PGAM1) is an important glycolytic enzyme that coordinates glycolysis, pentose phosphate pathway, and serine biosynthesis cells. Herein, we report PGAM1 required for homologous recombination (HR) repair of DNA double-strand breaks (DSBs) caused by DNA-damaging agents. Mechanistically, facilitates DSB end resection regulating the...
In multiple myeloma (MM), the hypoxic environment is an important factor causing tumor angiogenesis, which strongly correlated to disease progression and unfavorable outcome by activating key transcription factor, hypoxia-inducible factor-1α (HIF-1α). Gambogic acid (GA) major active ingredient of gamboge, has been shown possess antitumor effect in vitro vivo study. However, underlying molecular mechanism whether GA inhibits angiogenesis remains poorly understood. this study, we investigated...
Alpelisib selectively inhibits the p110α catalytic subunit of PI3Kα and is approved for treatment breast cancers harboring canonical PIK3CA mutations. In head neck squamous cell carcinoma (HNSCC), 63% mutations occur at hotspots. The oncogenic role remaining 37% noncanonical incompletely understood. We report a patient with HNSCC mutation (Q75E) who exhibited durable (12 months) response to alpelisib in phase II clinical trial. Characterization all 32 found using several functional...
Flow cytometry, as a powerful tool for immunomonitoring and quality control of peripheral blood mononuclear cells (PBMCs), is routinely used in clinical studies. However, flow cytometry based assays cryopreserved (cPBMCs) constitute challenge. Down-regulation surface intracellular markers, well impairment cell function might result from cryopreservation. Furthermore, protocols resting cPBMCs are available but diverse. Therefore, we performed standardization the process concerning position,...
Epigenetic therapies that cause genome-wide epigenetic alterations, could trigger local interplay between different histone marks, leading to a switch of transcriptional outcome and therapeutic responses treatment. However, in human cancers with diverse oncogenic activation, how pathways cooperate modifiers regulate the mark is poorly understood. We herein discover hedgehog (Hh) pathway reprograms methylation landscape breast cancer, especially triple-negative cancer (TNBC). This facilitates...
Hepatocellular carcinoma (HCC) exhibits strong intrinsic and acquired drug resistance which is the main obstacle to chemotherapy. Overexpression of ATP binding cassette (ABC) proteins correlates with activation mitogen activated protein kinase (MAPK) pathway in HCC. Here, we systematically investigated inhibition MAPK its role regulating HCC cell growth as well ABC MRP1 MRP3 expression.The Raf1 inhibitor (GW5074) different MEK inhibitors (U0126 AZD6244) were used treat cells identify their...
The study aimed to investigate the gender-related differences of disease onset, age distribution, blood type, clinical characteristics, and malignant behaviors differentiated thyroid carcinoma (DTC) in Chinese patients. A total 7385 consecutive cancer patients who underwent thyroidectomy were retrospectively reviewed. 4087 (55.3%) diagnosed as benign other (3298, 44.7%) malignant. DTC accounted for 97.6% tumor. More single nodules turned out be male compared multiple (46.9% vs. 40.4%, P =...
Combined effect of elevated blood pressure and occupational noise exposure on hearing loss have rarely been evaluated among Chinese population.This cross-sectional study was conducted in 242,811 participants. Logistic regression model performed to estimate the independent combined associations.Compared with participants without exposure, risk bilateral high-frequency (BHFHL) significantly higher for 10 years or more (odds ratio [OR] = 1.29, 95% confidence interval [95% CI] 1.23-1.35)....