A5003039278- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Immunodeficiency and Autoimmune Disorders
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Prostate Cancer Treatment and Research
- Pancreatic and Hepatic Oncology Research
- Chronic Lymphocytic Leukemia Research
- T-cell and Retrovirus Studies
- Estrogen and related hormone effects
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Histone Deacetylase Inhibitors Research
- Calcium signaling and nucleotide metabolism
- Protein Degradation and Inhibitors
- FOXO transcription factor regulation
- Ubiquitin and proteasome pathways
- Metabolism, Diabetes, and Cancer
- Family and Disability Support Research
- Immunotherapy and Immune Responses
- Autophagy in Disease and Therapy
Southwest University
2025
Guangzhou University of Chinese Medicine
2023-2025
Merck & Co., Inc., Rahway, NJ, USA (United States)
2023-2025
Southern University of Science and Technology
2025
Capital Medical University
2008-2024
First Affiliated Hospital of Soochow University
2023-2024
Soochow University
2023-2024
Chinese Academy of Sciences
2024
Beijing Anzhen Hospital
2008-2024
Peking University
2024
<h3>Background</h3> Odronextamab, a CD20×CD3 bispecific antibody that engages cytotoxic T cells to destroy malignant B cells, has demonstrated encouraging activity across multiple subtypes of relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma. <h3>Patients and methods</h3> This phase II study (ELM-2; NCT03888105) evaluated odronextamab in patients with R/R follicular lymphoma after two or more lines systemic therapy. Patients received intravenous 21-day cycles, step-up dosing cycle 1 help...
Abstract One of the biggest hurdles for development metabolism-targeted therapies is to identify responsive tumor subsets. However, metabolic vulnerabilities most human cancers remain unclear. Establishing link between signatures and oncogenic alterations receptor tyrosine kinases (RTK), well-defined cancer genotypes, may precisely direct intervention a broad patient population. By integrating metabolomics transcriptomics, we herein show that RTK activation causes distinct preference....
Summary Macrophages are particularly abundant and play an important role throughout the tumor progression process, namely, tumor‐associated macrophages (TAM) in microenvironment. TAM can be polarized to disparate functional phenotypes, M1 M2 macrophages. M1‐like type defined as pro‐inflammatory cells involved killing cancer cells, while M2‐like specially promote growth metastasis, tissue remodeling immunosuppression. In this study, we first found that integrin β 3 was highly expressed on...
Haemophagocytic lymphohistiocytosis (HLH) is a severe, even fatal, inflammatory condition. Epstein-Barr virus (EBV) infection-associated HLH (EBV-HLH) one of the most common types secondary HLH. Etoposide key drug in HLH-94/04 regimen. We sought to identify importance etoposide initial treatment EBV-HLH. Ninety-three patients with EBV-HLH all ages admitted our centre 2017 were divided into two groups according whether contained or not. The survival group whose therapy included (Group 1, 52...
Islet β cell death has been proved to contribute diabetes. Studies suggest that the activation of nuclear factor κB (NF-κB)-inducing kinase (NIK) is involved in dysfunction encountered obesity. However, pathological significance NIK diabetes remains largely unknown. Here, we report cell-specific overexpression (β-NIK-OE) results spontaneous male mice at a young age (≥10 weeks age), which likely due insulin deficiency, death, and insulitis. Importantly, inhibiting by small molecule B022...
TPS286 Background: The androgen receptor (AR) plays a pivotal role in prostate cancer pathogenesis, even after progression on androgen-directed therapies (ADT). In patients with mCRPC, activation of AR ligand binding domain (AR-LBD) somatic point mutations is common mechanism resistance to ADTs. Opevesostat (MK-5684; ODM-208) an oral, nonsteroidal inhibitor cytochrome P450 11A1 (CYP11A1), which catalyzes the first and rate-limiting step steroid biosynthesis. By inhibiting CYP11A1,...
<title>Abstract</title> Microsporidia are a group of intracellular and unicellular eukaryotic parasites, which can nearly infect all animals, including human beings. As the first identified microsporidia, <italic>Nosema bombycis</italic> is world-wide threat for silkworm eggs production, it cause congenital infection <italic>via</italic> transovarial transmission. It important pathogenesis elucidation to unravel molecular characteristics <italic>N. proliferation host immune responses in...
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening clinical syndrome. Central nervous system (CNS) involvement severe complication, which can lead to rapid disease development and higher morality. However, this has not been given enough attention in adult HLH. Therefore, we carried out study analyze the features, laboratory findings, treatment outcomes, other characteristics of HLH with CNS involvement.A retrospective analysis 96 patients combined between June 2003 December 2016...
Hemophagocytic lymphohistiocytosis (HLH) is a rare severe clinical syndrome. HLH manifesting during pregnancy has been paid much attention in recent years. Despite the specificity of pregnancy-related HLH, there not any consensus regarding its treatment. According to previous study, corticosteroid/IVIG mainstream therapy; however, efficacy controversial. Etoposide an important agent HLH-94 regimen; nevertheless, use limited because possible toxicity fetus. Methods: In this we summarized 13...
The clinical severity of Staphylococcus aureus (S. aureus) respiratory infection correlates with antibacterial gene signature. S. induces the expression an gene, as well a central stress response thus activating transcription factor 3 (ATF3). ATF3-deficient mice have attenuated protection against lethal pneumonia and higher bacterial load. We tested hypothesis that ATF3-related is based on increased function macrophages. Primary marrow-derived macrophages (BMDM) were used in vitro to...
Natural killer/T cell lymphoma (NKTCL) is a rare and aggressive malignancy with higher prevalence in Asia South America. However, the molecular genetic mechanisms underlying NKTCL remain unclear. Here, we identify somatic mutations of GNAQ (encoding T96S alteration Gαq protein) 8.7% (11/127) patients, through whole-exome/targeted deep sequencing. Using conditional knockout mice (Ncr1-Cre-Gnaqfl/fl), demonstrate that deficiency leads to enhanced NK survival. We also find suppresses tumor...
Hemophagocytic lymphohistiocytosis (HLH) is a severe disorder characterized by excessive secretion of cytokines. Even with the recommended HLH-94/2004 regimen, over 30% patients remain refractory to frontline therapy or relapse after an initial response, leading poor clinical outcomes. Ruxolitinib, JAK1/2 inhibitor targets key cytokines in HLH, has shown promising therapeutic effects. However, there been little attention given who do not respond ruxolitinib and whether escalating dose can...
Immune complexity status in the TME has been linked to clinical outcomes pancreatic ductal adenocarcinoma (PDAC) patients. assessments with current cell marker and density-based analyses do not identify original phenotypes of single cells multilineage selectivity, functional cells, or cellular spatial information tissues. Here, we describe a method that circumvents these problems. The combined strategy multiplexed IHC computational image cytometry multiparameter cytometric quantification...
Hemophagocytic lymphohistiocytosis (HLH) is a severe or even fatal inflammatory status caused by hereditary acquired immunoregulatory abnormality. Lymphoma-associated hemophagocytic (LAHS) kind of secondary HLH (sHLH). It suffers the worst outcome among sHLH. However, there no standard treatment strategy. The argument mainly focuses on whether an HLH-directed malignancy-directed approach should initially be adopted. Etoposide one key drugs in and also shows activity lymphomas. We sought to...
Inflammatory bowel disease (IBD) has been reported to be associated with NLRP3 inflammasome activation. Therefore inhibiting activation could a new approach treat IBD. Inflammasome inhibitors NLRP3-IN-2, JC124, and 3,4-methylenedioxy-β-nitrostyrene (MNS) were previously exert anti-inflammatory effects in various models but not the dextran sulfate sodium (DSS)–induced colitis model. Here, we showed that MNS was more efficient secretion of interleukin-1β (IL-1β) by blocking oligomerization...
T-lymphoblastic lymphoma (T-LBL) is a rare hematological malignancy with highly aggressive, unique clinical manifestations, and poor prognosis. Cell division cycle 27 (CDC27) was previously reported to be significant subunit of the anaphase-promoting complex/cyclosome. However, specific functions relevant mechanisms CDC27 in T-LBL remain unknown. Through immunohistochemistry staining, we identified that overexpressed tissues related tumor progression survival. Functional experiments...