A5100653668- Nanoplatforms for cancer theranostics
- Land Use and Ecosystem Services
- Insurance and Financial Risk Management
- Microbial Community Ecology and Physiology
- Advanced MRI Techniques and Applications
- Autophagy in Disease and Therapy
- Genetics, Aging, and Longevity in Model Organisms
- Cardiovascular Function and Risk Factors
- Advanced Glycation End Products research
- Conservation, Biodiversity, and Resource Management
- Advanced Antenna and Metasurface Technologies
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Hydrogels: synthesis, properties, applications
- Peptidase Inhibition and Analysis
- Herpesvirus Infections and Treatments
- Traditional Chinese Medicine Analysis
- 3D Printing in Biomedical Research
- Calcium signaling and nucleotide metabolism
- Tea Polyphenols and Effects
- Gut microbiota and health
- Electrospun Nanofibers in Biomedical Applications
- Extracellular vesicles in disease
- Autoimmune and Inflammatory Disorders Research
- Metamaterials and Metasurfaces Applications
Sichuan University
2024-2025
University of Electronic Science and Technology of China
2024-2025
Institute of Botany
2024-2025
Nanjing University of Chinese Medicine
2024-2025
Tsinghua University
2025
North China University of Science and Technology Affiliated Hospital
2025
Hebei Agricultural University
2025
University of Hong Kong
2025
Jiangsu University
2022-2024
Guangzhou Medical University
2022-2024
Abstract Background The triglyceride glucose (TyG) index has been proposed as a reliable marker of insulin resistance (IR) and an independent predictor cardiovascular disease risk. However, its prognostic value in patients with acute decompensated heart failure (ADHF) remains unclear. Methods A total 932 hospitalized ADHF from January 1st, 2018 to February 2021 were included this retrospective study. TyG was calculated ln [fasting level (mg/dL) × fasting plasma (mg/dL)/2]. Patients divided...
Repairment and replacement of organs tissues are part the history struggle against human diseases, in addition to research development (R&D) drugs. Acquisition processing specific substances physiological signals very important understand effects pathology treatment. These depend on available biomedical materials. The family diamond-like carbon coatings (DLCs) has been extensively applied many industrial fields. DLCs have also demonstrated be biocompatible, both vivo vitro. In cases,...
Safranine-catalyzed oxidative cyclization reaction of substituted 2-aminobenzamides and aldehydes to afford quinazolinone products.
Three-dimensional (3D) printable hydrogels with a shape memory effect have emerged as new class of 4D printing materials recently and found wide applications in various fields. However, synergistically endowing such good mechanical strength biocompatibility for biomedical uses remains challenging. In this study, series multiresponsive been prepared through dynamic covalent imine/Diels–Alder network from biocompatible starting modified gelatin poly(ethylene glycol)-based polymers. By further...
Abstract Background Circulating fibrinogen-to-albumin ratio (FAR) has been proposed as a novel inflammatory biomarker and cardiovascular disease risk predictor. However, its prognostic value in patients with acute decompensated heart failure (ADHF) different glycemic metabolic states remains ambiguous. Methods A total of 1031 hospitalized ADHF from January 2018 to May 2021 were included the study. The primary endpoints major adverse cardiac cerebral events (MACCEs). Patients categorized into...
Abstract Inhalation offers a non‐invasive method to administer drugs lungs, but achieving selective delivery pulmonary lesions while sparing normal lung tissues remains challenging. Here, the development of an inhalable chemotactic liposome designed for targeted modulation pre‐metastatic niche (PMN) is reported. The inhaled can migrate along chemokine gradients, preferentially accumulating in chemokine‐secreting PMNs within lung. Upon localized drug release, mitigates fibrosis, and disrupts...
DNA topoisomerases are essential molecular machines that manage topology in the cell and play important roles replication transcription. We find knocking down enzyme Topoisomerase Top2 or its mammalian homolog Top2b increases life span of S. cerevisiae , C. elegans mice. reduction also extends health mice alleviates pathologies aging multiple tissues. At cellular/molecular level, attenuates major hallmarks aging, such as cellular senescence, de-regulated nutrient sensing, epigenetic...
DNA topoisomerases are essential molecular machines that manage topology in the cell and play important roles replication transcription. We find knocking down enzyme Topoisomerase Top2 or its mammalian homolog Top2b increases life span of S. cerevisiae , C. elegans mice. reduction also extends health mice alleviates pathologies aging multiple tissues. At cellular/molecular level, attenuates major hallmarks aging, such as cellular senescence, de-regulated nutrient sensing, epigenetic...
Chemical exchange saturation transfer magnetic resonance imaging is an advanced technique that enables the detection of compounds at low concentrations with high sensitivity and spatial resolution has been extensively studied for diagnosing malignancy stroke. In recent years, emerging exploration chemical detecting pathological changes in neurodegenerative diseases opened up new possibilities early repetitive scans without ionizing radiation. This review serves as overview detailed...
We present a practical synthesis of 2’-hydroxy-3’,4’,5’,6’-tetramethoxyacetophenone, multi-substituted benzene derivative, via CuCl-catalyzed Ullmann-type coupling reaction with MeONa. 2’-Hydroxy-3’,4’,5’,6’-tetramethoxyacetophenone is the key intermediate for total various polymethoxyflavones....
ABSTRACT DNA topoisomerases are essential molecular machines that manage topology in the cell and play important roles replication transcription. We found knocking down enzyme topoisomerase Top2 or its mammalian homolog TOP2B increases lifespan of S. cerevisiae , C. elegans mice. reduction also extends health span mice alleviates pathologies aging multiple tissues. At cellular/molecular level, major hallmarks aging, including senescence, damage, deregulated nutrient sensing. observed changes...
K. pneumoniae is a major cause of bovine mastitis worldwide, making it difficult to control due its resistance multiple drugs. L. paraplantarum has been explored as promising new approach fighting mastitis. In this study, the probiotic potential and safety SDN1.2, well ex vivo in anti-inflammatory effects against pneumoniae-induced mastitis, were comprehensively investigated using bioinformatics analyses experimental validation methods. The results revealed that SDN1.2 exhibits non-hemolytic...
Background Previous epidemiological studies have identified a correlation between serum protein levels and Psoriatic Arthritis (PsA). However, the precise nature of this relationship remains uncertain. Therefore, our objective was to assess whether circulating 2,923 plasma proteins are associated with risk PsA, utilizing Mendelian randomization (MR) approach. Methods Two-sample MR analysis performed causal impact on PsA risk. Exposure data for were sourced from genome-wide association study...