A5101580861- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Immunotherapy and Immune Responses
- Hepatitis Viruses Studies and Epidemiology
- Liver physiology and pathology
- Parkinson's Disease Mechanisms and Treatments
- Immune Response and Inflammation
- Systemic Lupus Erythematosus Research
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Drug-Induced Hepatotoxicity and Protection
- Bioinformatics and Genomic Networks
- Heart Rate Variability and Autonomic Control
- Gastrointestinal disorders and treatments
- Cardiovascular Function and Risk Factors
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Disease and Adiposity
- Biological Research and Disease Studies
- Lipid metabolism and disorders
- Cancer-related gene regulation
- Lipid metabolism and biosynthesis
- Renal Diseases and Glomerulopathies
Nanjing Drum Tower Hospital
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Ruijin Hospital
2013-2025
Shanghai Jiao Tong University
2010-2025
Zhejiang Shuren University
2024
Beijing University of Chinese Medicine
2022-2023
Peking Union Medical College Hospital
2022
Xuzhou Medical College
2018
Second Affiliated Hospital of Xuzhou Medical College
2018
Shantou University
2017
Abstract Background The triglyceride glucose (TyG) index has been proposed as a reliable marker of insulin resistance (IR) and an independent predictor cardiovascular disease risk. However, its prognostic value in patients with acute decompensated heart failure (ADHF) remains unclear. Methods A total 932 hospitalized ADHF from January 1st, 2018 to February 2021 were included this retrospective study. TyG was calculated ln [fasting level (mg/dL) × fasting plasma (mg/dL)/2]. Patients divided...
We studied whether 48 weeks of pegylated interferon alfa-2b (peginterferon) add-on therapy increases serological response in hepatitis B virus (HBV) envelope antigen (HBeAg)-positive patients receiving nucleos(t)ide analogue (NA) therapy, compared with continued NA monotherapy.This randomized trial included HBeAg-positive compensated liver disease who were treated entecavir/tenofovir for >12 months and had an HBV DNA load <2000 IU/mL. Patients randomly assigned a 1:1 ratio to peginterferon...
Abstract Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is responsible for viral persistence. This study aimed to investigate the serum surrogate markers cccDNA and evaluate intrahepatic events associated with disease activity in HBeAg‐negative chronic hepatitis patients. Thirty‐three treatment‐naïve patients a negative HBeAg who had liver biopsy were studied. Active was defined as alanine aminotransferase >40 IU/L HBV >10,000 copies/ml. showed significant correlation...
Summary. Current guidelines recommend antiviral therapy for chronic hepatitis B (CHB) patients with elevated alanine aminotransferase (ALT) and high viral load. Scant histological data exist CHB persistently normal ALT (PNALT) because disease progression is thought to be rare. To identify potential predictors of significant histology in the presence PNALT, we compared clinical characteristics Chinese PNALT those ALT. Percutaneous liver biopsy was performed 522 ethnicity who had not...
ABSTRACT Background Babesiosis is a tick‐transmitted illness caused by intraerythrocytic protozoa of the genus babesia. The severity babesiosis ranges from asymptomatic infection to fatal disease. Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are common interrelated inflammatory disorders that almost occur in people aged over 50 years. This report presents first case concurrent GCA/PMR an old person. Case Presentation A 63‐year‐old man was admitted hospital with 1‐month history...
Backgrounds and Purpose Concurrent non-alcoholic fatty liver disease (NAFLD) in chronic hepatitis B (CHB) patients is a frequent increasingly concerning problem because of the NAFLD pandemic. Admittedly, can progress to steatohepatitis (NASH) severe fibrosis. Direct evidence fibrotic effect or NASH virus (HBV) infection remains lacking. We aimed reveal influence concurrent histologically proven diseases fibrogenesis with HBV infection. Methods performed retrospective cross-sectional study on...
Polyphyllin I (PPI) and polyphyllin II (PII) are the main active substances in Paris polyphylla. However, liver toxicity of these compounds has impeded their clinical application potential hepatotoxicity mechanisms remain to be elucidated. In this work, we found that PPI PII exposure could induce significant human cell line L-02 zebrafish a dose-dependent manner. The results proteomic analysis cells transcriptome indicated was associated with cholesterol biosynthetic pathway disorders, which...
Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is an acute deterioration of function on chronic disease with immune disorder. Th22 cells and IL-22 were correlated inflammatory autoimmune diseases. However, in the pathogenesis HBV-ACLF remains to be elucidated. It was investigated correlation between prognosis HBV-ACLF.Seventy-one 65 hepatitis patients recruited. The peripheral frequencies Th22, Th17 Th1, or IL-17 determined, using flow cytometry ELISA, respectively....
Off-treatment HBsAg reversion occurs in a considerable number of chronic hepatitis B(CHB) patients after IFN(interferon)-induced clearance. HBV vaccination protects the general population against infection. However, it remains unclear whether could prevent off-treatment CHB with (n = 199) clearance were included current study, comprising spontaneous group 51), NA (nucleoside/nucleotide analogues)-induced 36) and IFN-induced 112). Log-rank test was performed to compare cumulative incidences...
This study aimed to investigate whether peginterferon-α (IFN) add-on nucleos(t)ide analogs(NAs) can further reduce hepatocellular carcinoma(HCC) risk compared with NAs monotherapy in NA-treated patients chronic hepatitis B(CHB). In this multi-center randomized controlled trial "PARADISE study" (NCT05671315), CHB intermediate high of HCC after more than 24-week pretreatment were recruited, two groups at a ratio 1:2 and followed up for 240 weeks. group maintained monotherapy, while IFN+NAs...
(Pegylated) Interferon ([Peg]IFN) therapy leads to response in a minority of chronic hepatitis B (CHB) patients. Host genetic determinants are therefore demand.In this genome-wide association study (GWAS), CHB patients, treated with (Peg)IFN for at least 12 weeks ± nucleos(t)ide analogues within randomized trials or as standard care, were recruited 21 centers from Europe, Asia, and North America. Response 24 after treatment was defined combined e antigen (HBeAg) loss virus (HBV) DNA <2000...
Liver fibrosis plays an important role in the progression of liver disease, but there is a severe shortage direct and efficacious pharmaceutical clinical interventions. Literature research indicates that aspartic acid exhibits hepatoprotective properties. In this paper, 32 target compounds were designed synthesized utilizing as lead compound, which 22 new not reported literature. These screened for their inhibitory effects on COL1A1 promoter to assess vitro anti-liver activity summarized...
Summary Addition of peginterferon alpha ( PEG ‐ IFN add‐on) to entecavir ETV ) treatment after a short lead‐in phase results in more response than monotherapy HB eAg‐positive chronic hepatitis B infection CHB ). This study is the first assess long‐term efficacy this strategy. Patients who received ± 24 weeks add‐on global trial ARES study) and completed follow‐up were eligible participate observational LTFU if they had at least one combined eAg HBV DNA measurement beyond week 96 study. The...
Abstract Aim To investigate the diagnostic utility of corneal confocal microscopy (CCM) for small fiber neuropathy in type 2 diabetes. Materials and Methods There were 186 participants with diabetes enrolled this cross‐sectional research. Pure mixed defined using clinical examination, electromyography, quantitative sensory testing. Demographics data, parameters, other measures compared among groups. The was assessed by receiver operating curve. Results Of patients, 24.7% had a pure 17.2%...
Liver fibrosis is a vital cause of morbidity in patients with liver diseases and developing novel anti-fibrotic drugs imperative. Isovalerylspiramycin I (ISP I) as major component carrimycin applied to upper respiratory infections, was first found possess potential. The present study aims evaluate the functions mechanisms ISP protecting against fibrosis. According our results, not only reduced expressions fibrogenic markers LX-2 cells but also appeared great protective effects on injury bile...
Summary It is unknown whether peginterferon ( PEG ‐ IFN ) add‐on to entecavir ETV leads more HB sAg decline compared monotherapy or combination therapy, and therapy may prevent increase after cessation. We performed a post hoc analysis of 396 eAg‐positive patients treated for 72 weeks with + 24 from week 48 (add‐on, n = 85), 90), 52 111) lamivudine (combination, 110) within 2 randomized trials. was assessed at the end EOP 6 months EOF discontinuation. Differences in baseline characteristics...
The diversity of HCV genotypes is ever-evolving and requires continuous surveillance. aim this study was to investigate the dynamics genotypes, their associated demographic clinical patterns in China. By searching computerized hospital information system, a total 1155 HCV-positive patients eligible for analysis were retrospectively identified from 12 380 consecutive in-patients Department Infectious Diseases, Ruijin Hospital China between 2009 2014. percentages genotype 1, 2, 3, or 6 61.3%,...
To investigate whether peripheral neuropathy scale scores are associated with myocardial infarction (MI) in patients type 2 diabetes mellitus (T2DM).In this cross-sectional study, 32,463 T2DM were enroled from 103 tertiary hospitals 25 Chinese provinces. Based on a history of MI, participants divided into the MI group (n = 4170) and non-MI 28,293). All assessed using four scales, namely, Neurological Symptom Score (NSS), Disability (NDS), Toronto Clinical Scoring System (TCSS), Michigan...