A5101964647- Prenatal Screening and Diagnostics
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Plant tissue culture and regeneration
- Hepatitis C virus research
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Genomic variations and chromosomal abnormalities
- Lung Cancer Diagnosis and Treatment
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Acute Kidney Injury Research
- RNA and protein synthesis mechanisms
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- CRISPR and Genetic Engineering
- Bacteriophages and microbial interactions
- RNA modifications and cancer
- Retinal and Macular Surgery
- S100 Proteins and Annexins
- Heme Oxygenase-1 and Carbon Monoxide
- Caveolin-1 and cellular processes
- Tuberous Sclerosis Complex Research
- Neonatal Respiratory Health Research
- Light effects on plants
Northeast Forestry University
2024
Innovation Team (China)
2024
Second Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
Wuhan University
2024
Xi'an Medical University
2024
Xi’an Children’s Hospital
2024
Xi'an Jiaotong University
2024
Ruijin Hospital
2021-2024
Shanghai Jiao Tong University
2021-2024
Background: The outbreak of 2019 novel coronavirus disease (COVID-19) caused not only extraordinary public health concerns but also tremendous psychological distress, particularly among medical staffs. We aimed to investigate the prevalence rate insomnia and confirm related social factors staffs in hospitals during COVID-19 outbreak. Method: Medical China were recruited, including frontline workers. questionnaire obtained demographic data, self-design questions outbreak,...
Engineering of genetic networks with artificial signaling pathways (ASPs) can reprogram cellular responses and phenotypes under different circumstances for a variety diagnostic therapeutic purposes. However, construction ASPs between originally independent endogenous genes in mammalian cells is highly challenging. Here we report an amplifiable RNA circuit that theoretically build regulatory connections any cells. We harness the system catalytic hairpin assembly combination controllable...
Abstract Tumor cell-intrinsic programmed death-ligand 1 (PD-L1) signals mediate tumor initiation, progression and metastasis, but their effects in ameloblastoma (AM) have not been reported. In this comprehensive study, we observed marked upregulation of PD-L1 AM tissues revealed the robust correlation between elevated expression increased growth recurrence rates. Notably, found that overexpression markedly self-renewal capacity promoted tumorigenic processes invasion hTERT + -AM cells,...
To elucidate the function of cold resistance regulatory gene FmNAC1 from Fraxinus mandshurica, this study identified role that overexpression plays in tobacco growth and stress regulation. The cloned F. mandshurica is 891 bp length encodes 296 amino acids. Our subcellular localization analysis confirmed primarily located nucleus functions as a transcription factor. responsive to NaCl stress, well induction IAA, GA, ABA hormone signals. further its resistance, four transgenic lines...
Increasing evidence has shown the effectiveness of surgery for stage IV non-small cell lung cancer (NSCLC). Present study aims to summarize experience our institution in dealing with advanced NSCLC context multimodality therapy including surgery.Patients underwent surgical resection diagnosed before or during from January 2014 June 2017 at Tangdu Hospital were included this study.There 88 patients enrolled study. Among them, 35 pleural metastases, 18 brain oligometastases, 25 extra-brain...
Protein-coding gene LIM Domain Kinase 1 (LIMK1) is upregulated in various tumors and reported to promote tumor invasion metastasis. However, the prognostic values of LIMK1 correlation with immune infiltrates lung adenocarcinoma are still not understood. Therefore, we evaluated role its adenocarcinoma.Transcriptional expression profiles between tissues normal were downloaded from Cancer Genome Atlas (TCGA). The protein was assessed by Clinical Proteomic Tumor Analysis Consortium (CPTAC) Human...
Background Cognitive–behavioural therapy for insomnia (CBTi) is the first-line treatment those with this sleep disorder. However, depressive and anxiety symptoms often co-occur acute insomnia, which may affect effectiveness of CBTi treatment. Aims This study aimed to determine impact on efficacy in treating insomnia. Methods A single-arm clinical trial was conducted among individuals who have Participants underwent self-guided 1-week. Their were evaluated using Insomnia Severity Index...
Abstract We aimed to compare the diagnostic efficiency of pro GRP and NSE on SCLC investigate whether change level would predict therapeutic response. Patients who were firstly diagnosed pathologically in Nanjing Chest Hospital measured consecutively enrolled study. Pro was detected using Elecsys Assay. Totally 75 , 234 NSCLC 264 benign lung diseases ( BLD ) enrolled. Both levels significantly higher than those extensive stage which limited P ≤ .001). The that but when two biomarkers bind...
Background: Acute kidney injury (AKI) is closely linked to the pathogenesis of sepsis. Oxidative stress can affect development AKI by increasing damage renal tubular epithelial cells. Astragaloside IV (AS-IV) a natural saponin widly verified beneficial for ameliorating sepsis-induced injury. However, underlying mechanisms AS-IV on relieving oxidative in cells are yet be established. Purpose: We aimed investigate whether could attenuate mitochondrialdysfunction and apoptosis reveal its...
Abstract Objectives Ameloblastoma (AM), a locally aggressive tumor with extensive growth capacity, causes significant damage to the jaw and affects facial appearance. Although high prevalence of BRAF V600E mutation in AM is known, its specific impacts on patients remain unclear. Thus, present study investigated role mutation, thereby focusing impact invasion growth. Materials Methods Immunohistochemical analysis was used compare V600E, MMP2, MMP9, Ki‐67 expressions ( n = 49), normal oral...
To elucidate the function of cold-resistance regulatory gene FmNAC1 from Fraxinus mandshurica Rupr., this study identified role that overexpression plays in tobacco growth and cold-stress regulation. The cloned F. is 891 bp length encodes 296 amino acids. Our subcellular localization analysis confirmed primarily located nucleus functions as a transcription factor. responsive to cold NaCl stress, well induction IAA, GA, ABA hormone signals. further its resistance, four transgenic lines...
Abstract Background Papillary thyroid carcinoma (PTC) accounts for about 85% of cancer cases. Transmembrane protein 252 (TMEM252) is a gene encoding transmembrane that has only been reported to be associated with triple‐negative breast cancer. Herein, we first elucidated the physiological roles and possible regulatory proteins TMEM252 in PTC pathogenesis. Methods Quantitative real‐time polymerase chain reaction, western blot, immunohistochemical analyses were utilized ascertain relative...
To evaluate the diagnostic and prognostic value of CSF presepsin levels in patients with postneurosurgical ventriculitis/meningitis (PNVM).We conducted a case-control study to achieve our aims. First, we prospectively enrolled who had undergone neurosurgery Beijing Tiantan Hospital from June November 2020 measured 8 biomarkers, including other meningitis biomarkers. The accuracies were evaluated by determining values for area under receiver operating characteristic curve (AUC).Two hundred...
Abstract Background Trisomy 21 is a common aneuploid condition in humans and accounts for approximately one quarter of all live births. To date, early diagnosis remains challenging task. Metabolomics may prove an innovative tool to study the pathophysiology at functional level. Methods Ultra‐performance liquid chromatography coupled with mass spectrometer (UPLC‐MS) was used untargeted metabolomic analysis amniotic fluid samples from women having normal trisomy fetuses. Results Many...
Present study aims to explore the surgery patterns and survival of T4N2 NSCLC in real-world condition. Clinical stage patients Surveillance, Epidemiology End Result Program were extracted. Cox regression was used for calculation hazard ratio (HR) confidence interval (CI), landmark analysis test at different cut-off time points. There 1445 eligible included, which 306 received alone, 390 induction therapy, 749 adjuvant therapy. For resection types, 1210 lobectomy 235 pneumonectomy. Among...
Abstract Background Accumulating evidence suggests circular RNAs (circRNAs) act as regulators in cancer progression. However, the function of circRNAs lung adenocarcinoma is still uncertain. The purpose this study was to investigate hsa_circ_0009618 Methods CircRNA microarray performed screen circRNA expression profiles adenocarcinoma. identified for further and verified by quantitative real-time PCR (qRT-PCR) tissues cell lines. Cell proliferation examined 3-(4,5-Dimethylthiazol-2-yl)-...
Objective: Insulin attaches insulin receptor to activate the PI3-kinase/Akt signaling maintain glucose homeostasis and inhibit apoptosis. This study determined whether preconditioning with protects kidney against ischemia-reperfusion injury (IRI). Methods: Kidney IRI was performed in C57BL/6 mice by clamping renal vessels for 30 min, followed reperfusion 24 h. A total subcutaneous 0.1 unit of along 10% drinking water treated on h before IRI. The function injuries were investigated through...
Abstract Background Macro-creatine kinase (macro-CK) type 1, a macroenzyme composed of creatine (CK) and immunoglobulin, is associated with hypothyroidism, tumour, autoimmune diseases, myositis, cardiovascular may even be found in the absence pathology. However, its relationship coronavirus disease (COVID-19) infection remains unreported. Case summary An 11-year-old male patient presented recurrent myocardial enzyme abnormalities, mainly manifested as elevated activities CK isoenzyme...
Background Research on serum metabolite profiles in thyroid autoimmunity (TAI) patients during early pregnancy is currently limited. Aim & Methods The current study aimed to identify differential metabolites and assess the relationship between outcomes metabolic abnormalities individuals with TAI. This research included 26 pregnant women TAI 30 healthy controls (HC). We employed a liquid chromatograph mass spectrometer (LC-MS) analyze changes two groups. Results Newborns had lower birth...