A5046274878- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Nanoplatforms for cancer theranostics
- RNA Research and Splicing
- MicroRNA in disease regulation
- Metabolomics and Mass Spectrometry Studies
- Sarcoidosis and Beryllium Toxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Glycosylation and Glycoproteins Research
- Software Reliability and Analysis Research
- Software Engineering Research
- Ferroptosis and cancer prognosis
- Biofuel production and bioconversion
- Viral-associated cancers and disorders
- Computational Drug Discovery Methods
- Tissue Engineering and Regenerative Medicine
- Endometriosis Research and Treatment
Zhejiang University
2006-2024
Peking University
2011-2024
Huazhong University of Science and Technology
2017-2024
Lanzhou University
2024
First Hospital of Lanzhou University
2024
State Key Laboratory of Digital Medical Engineering
2020-2024
Hainan Medical University
2024
Tongji Hospital
2017-2024
Southeast University
2005-2024
Tongji University
2008-2024
Knowledge of therapeutic targets and early drug candidates is useful for improved discovery. In particular, information about target regulators the patented agents facilitates research regarding druggability, systems pharmacology, new trends, molecular landscapes, development discovery tools. To complement other databases, we constructed Therapeutic Target Database (TTD) with expanded (i) target-regulating microRNAs transcription factors, (ii) target-interacting proteins, (iii) their...
Abstract Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF cells, leading to telogen–anagen transition (TAT) around the wound and de novo regeneration, mostly through TNF signalling. Both knockout overexpression attenuate neogenesis wounds, suggesting dose-dependent induction by TNF, which is consistent with TNF-induced AKT signalling vitro . β-catenin...
Abstract Biological processes (like microbial growth & physiological response) are usually dynamic and require the monitoring of metabolic variation at different time-points. Moreover, there is clear shift from case-control (N=2) study to multi-class (N>2) problem in current metabolomics, which crucial for revealing mechanisms underlying certain process, disease metastasis, etc. These time-course metabolomics have attracted great attention, data normalization essential removing...
Abstract Mass spectrometry-based proteomic technique has become indispensable in current exploration of complex and dynamic biological processes. Instrument development largely ensured the effective production data, which necessitates commensurate advances statistical framework to discover optimal signature. Current mainly emphasizes generalizability identified signature predicting independent data but neglects reproducibility among signatures from independently repeated trials on different...
Triptolide (TPL), a main active ingredient of Tripterygium wilfordii has been shown to exert anti-inflammatory effect. The role TPL on glomerular diseases remains unclear.This study aims investigate the potential effect in rats with membranous glomerulonephritis (MGN).Our data showed that pathological kidney damage was significantly alleviated by treatment MGN rats. We also found exhibited higher (p < 0.01) level inflammatory cytokines (TNF-α, IL-1β and MCP-1) than those normal group, while...
Abstract The absorption, distribution and excretion of drugs are largely determined by their transporters (DTs), the variability which has thus attracted considerable attention. There three aspects variability: epigenetic regulation genetic polymorphism, species/tissue/disease-specific DT abundances, exogenous factors modulating activity. data each aspect essential for clinical study, a collective consideration among multiple becomes crucial in precision medicine. However, no database is...
Abstract Mesenchymal stem cells ( MSC s) hold profound promise in tissue repair/regeneration. However, s undergo remarkable spontaneous differentiation and aging during monolayer culture expansion. In this study, we found that 2–3 days of three‐dimensional (3D) spheroid human (h had been expanded for six passages increased their clonogenicity potency to neuronal cells. Moreover, accordance with these changes, the expression levels mi RNA which were involved cell changed histone H3...
Abstract Three‐dimensional (3D) culture has been shown to improve pluripotent gene expression in mesenchymal stem cells ( MSC s), but the underlining mechanisms were poorly understood. Here, we found that relaxation of cytoskeleton tension s 3D was critically associated with expressional up‐regulation Nanog. Cultured spheroids, showed decreased integrin‐based cell–matrix adhesion increased cadherin‐based cell–cell interaction. Different from 2D culture, where exhibited branched and...
Drug-metabolizing enzymes (DMEs) are critical determinant of drug safety and efficacy, the interactome DMEs has attracted extensive attention. There 3 major interaction types in an interactome: microbiome-DME (MICBIO), xenobiotics-DME (XEOTIC) host protein-DME (HOSPPI). The data each type essential for metabolism, collective consideration multiple implication future practice precision medicine. However, no database was designed to systematically provide all DME interactions. Here, a...
We introduce a novel paradigm to unobtrusively and optically measure blood pressure (BP) without calibration. The algorithm combines photoplethysmography (PPG) waveform analysis biometrics estimate BP, was evaluated in subjects with various age, height, weight BP levels (n = 1249). In the young population (<50 years old) low, medium high systolic pressures (SBP, <120 mmHg; 120-139 ≥140 mmHg), fitting errors are 6.3 ± 7.2, -3.9 7.2 -20.2 14.2 mmHg for SBP respectively; older (>50 same...
Abstract Widespread drug resistance has become the key issue in global healthcare. Extensive efforts have been made to reveal not only diverse diseases experiencing resistance, but also six distinct types of molecular mechanisms underlying this resistance. A database that describes a comprehensive list with (not just cancers/infections) and all is now urgently needed. However, no such available date. In study, describing information named ‘DRESIS’ was therefore developed. It introduced (i)...
Abstract Distinct from the traditional diagnostic/prognostic biomarker (adopted as indicator of disease state/process), therapeutic (ThMAR) has emerged to be very crucial in clinical development and practice all therapies. There are five types ThMAR that have been found play indispensable roles various stages drug discovery, such as: Pharmacodynamic Biomarker essential for guaranteeing pharmacological effects a therapy, Safety critical assessing extent or likelihood therapy-induced toxicity,...
Abstract Cumulative studies have established the significance of transfer RNA-derived small RNA (tsRNA) in tumorigenesis and progression. Nevertheless, its function mechanism pancreatic cancer metastasis remain largely unclear. Here, we screened identified tiRNA-Val-CAC-2 as highly expressed samples by tsRNA sequencing. We also observed elevated levels serum patients who developed metastasis, with high exhibited a worse prognosis. Additionally, knockdown inhibited vivo vitro, while...
Core fucosylation is one of the most important glycosylation events in progression liver cancer. For this study, we used an easily handled L-fucose analog, 2-fluoro-L-fucose (2FF), which interferes with normal synthesis GDP-fucose, and verified its potential roles regulating core cell behavior HepG2 cancer line. Results obtained from lectin blot flow cytometry analysis clearly showed that 2FF treatment dramatically inhibited fucosylation, was also confirmed via mass spectrometry analysis....
PhI(OCOCF3)2 acts as both a nonmetal oxidant and an iodination reagent to trigger iodocyclization of N-arylpropynamides while selectively affording iodinated quinolin-2-ones or the spiro[4,5]trienone skeleton, depending on substituent pattern. In cases where N-arylpropynamide bears para-fluorine aniline ring, spiro compound is formed via exclusive defluorination process; otherwise, product was quinolin-2-one.
Abstract Background Both N6-methyladenosine (m6A) modification and lncRNAs play an important role in the carcinogenesis cancer inhibition of ovarian (OC). However, involved m6A regulation (LI-m6As) have never been reported OC. Herein, we aimed to identify validate a signature based on LI-m6A for Methods RNA sequencing profiles with corresponding clinical information associated OC 23 regulators were extracted from TCGA. The Pearson correlation coefficient (PCC) between (|PCC|> 0.4 p <...
Objective. This study aimed to evaluate the relationship between branched-chain amino acids (BCAAs), metabolic syndrome (MS), and other cardiovascular (CV) risk factors in middle-aged elderly Chinese population at high for development of disease (CVD). Methods. 1302 subjects were enrolled from Huai’an Diabetes Prevention Program. Results. BCAAs levels positively correlated with MS, its components, CV profile. The odds ratio (OR) MS among fourth quartile showed a 2.17-fold increase compared...
6-mercaptopurine (6-MP) contributes substantially to remarkable improvement in the survival of childhood acute lymphoblastic leukemia (ALL) patients. However, 6-MP also has dose-limiting toxicities, particularly life-threatening myelosuppression, due genetic polymorphisms enzymes that metabolize 6-MP. Promising biomarkers for predicting 6-MP-induced leukopenia is still unclear Chinese population. Here, we evaluated associations NUDT15, TPMT and ITPA genotypes with intolerance our cohort ALL...
The therapeutic effect of mesenchymal stem cells (MSCs) in tissue repair/regeneration is substantially dampened by the loss primitive properties and poor engraftment to target organs. In this study, multipotency cell sizes human MSCs, which had been expanded monolayer culture for several passages, were dramatically restored after an episode three-dimensional (3D) spheroid culture. Unlike MSCs derived from monolayer, caused embolism blindness, 3D spheroids did not cause vascular obstructions,...
It has been suggested that serum branched-chain amino acids (BCAAs) are associated with the incident, progression and prognostic of type 2 diabetes. However, role BCAAs in metabolic dyslipidemia (raised triglycerides (TG) reduced high-density lipoprotein cholesterol (HDL-C)) remains poorly understood. This study aims to investigate 1) association total (TC), TG, HDL-C low-density (LDL-C) 2) between levels risk a community population different glucose homeostasis.Demographics data blood...
Chemotherapy is the first-line treatment option for patients with lung cancer. However, therapeutic resistance occurs through an incompletely understood mechanism. Our research wants to investigate influence of Caveolin-1 (Cav-1) on sensitivity cancer in vitro. Results this study demonstrated that Cav-1 levels were markedly inhibited A549 cells after exposure cisplatin. Knockdown caveolin further enhanced cisplatin-triggered death cells. The functional investigation inhibition amplified...