D. J. Kong
A5046997584- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Dark Matter and Cosmic Phenomena
- Particle Detector Development and Performance
- Cosmology and Gravitation Theories
- RNA modifications and cancer
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Hair Growth and Disorders
- Black Holes and Theoretical Physics
- Atomic and Subatomic Physics Research
- Astrophysics and Cosmic Phenomena
- Dermatologic Treatments and Research
- Neutrino Physics Research
- Energy Load and Power Forecasting
- Cancer and Skin Lesions
- Skin and Cellular Biology Research
- RNA Interference and Gene Delivery
- Plasma Applications and Diagnostics
- Cancer-related molecular mechanisms research
- Superconducting Materials and Applications
- Autophagy in Disease and Therapy
- Radiation Detection and Scintillator Technologies
- Gamma-ray bursts and supernovae
Second Affiliated Hospital of Zhejiang University
2020-2025
Jilin University
2024-2025
Chinese Academy of Sciences
2003-2024
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2024
Shenyang Institute of Engineering
2024
Tsinghua University
2017-2024
University Town of Shenzhen
2023-2024
University of Jinan
2023-2024
Jilin Medical University
2024
Kyungpook National University
2009-2022
Abstract Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF cells, leading to telogen–anagen transition (TAT) around the wound and de novo regeneration, mostly through TNF signalling. Both knockout overexpression attenuate neogenesis wounds, suggesting dose-dependent induction by TNF, which is consistent with TNF-induced AKT signalling vitro . β-catenin...
We observe a narrow enhancement near 2m(p) in the invariant mass spectrum of pp pairs from radiative J/psi-->gammapp decays. No similar structure is seen J/psi-->pi(0)pp The results are based on an analysis 58 x 10(6) event sample J/psi decays accumulated with BESII detector at Beijing electron-positron collider. can be fit either S- or P-wave Breit-Wigner resonance function. In case S-wave fit, peak below M=1859(+3)(-10) (stat)+5-25(syst) MeV/c(2) and total width Gamma<30 90% confidence...
We report values of R = sigma(e(+)e(-)-->hadrons)/sigma(e(+)e(-)-->mu(+)mu(-)) for 85 center-of-mass energies between 2 and 5 GeV measured with the upgraded Beijing Spectrometer at Electron-Positron Collider.
Using the upgraded Beijing Spectrometer, we have measured total cross section for e+e− annihilation into hadronic final states at center-of-mass energies of 2.6, 3.2, 3.4, 3.55, 4.6, and 5.0 GeV. Values R, σ(e+e−→hadrons)/σ(e+e−→μ+μ−), are determined.Received 28 July 1999DOI:https://doi.org/10.1103/PhysRevLett.84.594©2000 American Physical Society
<title>Abstract</title> Background Fibrobalst plays a critical role in heart physiology and pathology, yet their immunological transplanted grafts remains unclear, particularly the mechanisms involved. Methods Heart transplantation was performed mouse models (C57BL/6J, BALB/c, Postn<sup>MCM</sup>, Rosa26-tdTomato, ATG5<sup>floxp/floxp</sup>). Single-cell RNA sequencing, qPCR, western blotting, flow cytometry, immunofluorescence staining were used to identify fibroblast subpopulations assess...
5-Methylcytosine (m 5 C) is one of the major post-transcriptional modifications in mRNA and highly involved pathogenesis various diseases. However, capacity existing assays for accurately comprehensively transcriptome-wide m C mapping still needs improvement. Here, we develop a detection method named DRAM (deaminase reader protein assisted RNA methylation analysis), which deaminases (APOBEC1 TadA-8e) are fused with proteins (ALYREF YBX1) to identify sites through deamination events...
5-Methylcytosine (m 5 C) is one of the post-transcriptional modifications in mRNA and involved pathogenesis various diseases. However, capacity existing assays for accurately comprehensively transcriptome-wide m C mapping still needs improvement. Here, we develop a detection method named DRAM (deaminase reader protein assisted RNA methylation analysis), which deaminases (APOBEC1 TadA-8e) are fused with proteins (ALYREF YBX1) to identify sites through deamination events neighboring sites....
Abstract An increasing number of studies show that platelet‐rich plasma (PRP) is effective for androgenic alopecia (AGA). However, the underlying cellular and molecular mechanisms along with its effect on hair follicle stem cells are poorly understood. In this study, we designed to induce platelets in PRP release factors by calcium chloride (PC) or sonication where platelet lysates (PS) supernatants lysate (PSS) were used evaluate their activation regeneration. We found PSS PS exhibited a...
Abstract Objectives There are significant clinical challenges associated with alopecia treatment, including poor efficiency of related drugs and insufficient hair follicles (HFs) for transplantation. Skin‐derived precursors (SKPs) exhibit great potential as stem cell‐based therapies regeneration; however, the proliferation hair‐inducing capacity SKPs gradually decrease during culturing. Materials Methods We describe a 3D co‐culture system accompanied by kyoto encyclopaedia genes genomes gene...
Abstract The prevalence of alopecia has increased recently. Hair loss is often accompanied by the resting phase hair follicles (HFs). Dermal papilla (DP) plays a crucial role in HF development, growth, and regeneration. Activating DP can revive HFs. Augmenting WNT/β‐catenin signaling stimulates growth. However, factors responsible for activating HFs effectively are unclear. In this study, we investigated epidermal cytokines that activate effectively. We overexpressed β‐catenin both vivo...
Accumulating data support that tissue stem cells give rise to cancer cells.Hair follicle (HFSCs) undergo cyclic quiescence and activation may sever as the origin of cutaneous squamous cell carcinoma (SCC).Pten is a tumor suppressor gene frequently mutated in hereditary syndromes such Cowden disease, which featured with papillomatosis tissues hyperkeratosis acral region skin.Additionally, mice keratinocyte-specific Pten deficiency (k5-Pten -/-mice) show epidermal hyperplasia spontaneous...
Background. Graft rejection continues to be a major barrier long-term engraftment after transplantation. Autophagy plays an important role in cardiac injury pathogenesis. The bromodomain and extraterminal protein inhibitor (S)-tert-butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate (JQ1) inhibits inflammatory responses. However, the beneficial effect of JQ1 on transplant potential autophagy protective graft survival are yet...
Hadronic decays of the P-wave spin-triplet charmonium states χcJ(J=0,1,2) are studied using a sample ψ(2S) collected by BES detector operating at BEPC storage ring. Branching fractions for χc1→K0SK+π−+c.c., χc0→K0SK0S, χc2→K0SK0S, χc0→φφ, χc2→φφ and χcJ→K+K−K+K− measured first time, those χcJ→π+π−π+π−, χcJ→π+π−K+K−, χcJ→π+π−p¯p χcJ→3(π+π−) with improved precision. In addition, we determine masses χc0 ηc to be Mχc0=3414.1±0.6(stat)±0.8(syst)MeV Mηc=2975.8±3.9(stat)±1.2(syst)MeV. Received 15...
In order to elucidate the origin of plastid division gene ftsZ in green plant lineage, and understand significance this divergence for function FtsZ proteins plants, two full-length cDNAs (accession numbers AF449446 AB084236) were isolated from Chlamydomonas reinhardtii, a base species lineage. A phylogenetic analysis based on amino acid sequences eukaryotic FtsZs reveals that an ancient duplication occurred after endosymbiotic event. The implies families might play indispensable role at early stage.
The processes $\ensuremath{\psi}(2S)\ensuremath{\rightarrow}\ensuremath{\gamma}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$, $\ensuremath{\gamma}{K}^{+}{K}^{\ensuremath{-}}$, and $\ensuremath{\gamma}p\overline{p}$ have been studied using a sample of $3.79\ifmmode\times\else\texttimes\fi{}{10}^{6}\ensuremath{\psi}(2S)$ decays. We determine the total width ${\ensuremath{\chi}}_{c0}$ to be...
The cross section for e+e−→ρπ has been measured by the BES detector at BEPC center-of-mass energies covering a 40 MeV interval spanning Jψ resonance. data are used to search vector gluonium state hypothesized Brodsky, Lepage, and Tuan as an explanation of ρπ puzzle in charmonium physics. shape is compatible with that total hadronic section. No distortions indicating presence glueball seen.Received 19 October 1995DOI:https://doi.org/10.1103/PhysRevD.54.1221©1996 American Physical Society
Using a sample of 3.8 M ψ(2S) events accumulated with the BES detector, process ψ(2S)→π+π−J/ψ is studied. The angular distributions are compared general decay amplitude analysis Cahn. We find that dipion system requires some D wave amplitude, as well S wave. On other hand, J/ψ−(π+π−) relative momentum consistent being pure have been fit to heavy quarkonium models, including Novikov-Shifman model. This model, which written in terms parameter κ, predicts pions should be present. determine...
A comparison of the rates for ψ(2S)→π+π−J/ψ, J/ψ→l+l− and J/ψ→ anything is used to determine J/ψ leptonic branching fractions. The results are B(J/ψ→e+e−)=(5.90±0.05±0.10)% B(J/ψ→μ+μ−)=(5.84±0.06±0.10)%, where first error statistical second systematic. Assuming lepton universality, fraction B(J/ψ→l+l−)=(5.87±0.04±0.09)% per species. This result estimate QCD scale factor ΛMS¯(4) strong coupling constant αs. Received 11 June 1998DOI:https://doi.org/10.1103/PhysRevD.58.092006©1998 American...
Purely leptonic decays of the charged D meson have been studied using reaction e+e−→D∗+D− at a center mass energy 4.03 GeV. A search was performed for D→μνμ recoiling against D0 or D+ which had reconstructed from its hadronic decay products. single event candidate found in e+e−→D∗+D−, where D∗+→π+D0 with D0→K−π+, and D− decaying via D−→μ−ν̄μ. This yields branching fraction value B(D→μνμ)=0.08−0.05−0.02+0.16+0.05%, corresponding pseudoscalar constant fD=300−150−40+180+80 MeV.
The decays of the $\ensuremath{\psi}(2S)$ into vector plus tensor meson final states have been studied for first time using BES detector. We determine upper limits on branching fractions $\ensuremath{\omega}{f}_{2}$, $\ensuremath{\rho}{a}_{2}$, ${K}^{*0}{\overline{K}}_{2}^{*0}+\mathrm{c}.\mathrm{c}.$, and $\ensuremath{\varphi}{f}_{2}^{\ensuremath{'}}(1525)$ that are, in each case, significantly smaller than corresponding $J/\ensuremath{\psi}$ meson, scaled according to expectations perturbative QCD.