A5085888523- Wound Healing and Treatments
- Periodontal Regeneration and Treatments
- Antimicrobial Peptides and Activities
- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Dermatologic Treatments and Research
- Facial Rejuvenation and Surgery Techniques
- Diabetic Foot Ulcer Assessment and Management
- Hair Growth and Disorders
- Pressure Ulcer Prevention and Management
- Mesenchymal stem cell research
- Head and Neck Cancer Studies
- Reconstructive Surgery and Microvascular Techniques
- Planarian Biology and Electrostimulation
- Oral health in cancer treatment
- Dermatology and Skin Diseases
- Body Contouring and Surgery
- Lung Cancer Research Studies
- Neural Networks and Applications
- Tissue Engineering and Regenerative Medicine
- Protease and Inhibitor Mechanisms
- Advanced Scientific Research Methods
- Cancer, Stress, Anesthesia, and Immune Response
- Blood properties and coagulation
- Nerve injury and regeneration
Southern Medical University
2018-2024
Vrije Universiteit Amsterdam
2020-2024
Amsterdam University Medical Centers
2020-2024
Academic Center for Dentistry Amsterdam
2020-2024
General Hospital of Guangzhou Military Command
2018-2023
Guangdong Pharmaceutical University
2021
People’s Hospital of Linqing
2021
National Natural Science Foundation of China
2021
Christie's
2021
Command Hospital
2020
Abstract An increasing number of studies show that platelet‐rich plasma (PRP) is effective for androgenic alopecia (AGA). However, the underlying cellular and molecular mechanisms along with its effect on hair follicle stem cells are poorly understood. In this study, we designed to induce platelets in PRP release factors by calcium chloride (PC) or sonication where platelet lysates (PS) supernatants lysate (PSS) were used evaluate their activation regeneration. We found PSS PS exhibited a...
The high mortality rate of patients with diabetic foot ulcers is urging the appearance an effective biomedical drug. Senescence one major reasons aging-induced decline in wound. Our previous studies have demonstrated anti-senescence effect secretomes derived from human fetal mesenchymal stem cells (hfMSC). present study tends to explore potential role hfMSC secretome (HFS) wound healing through anti-aging. Meanwhile, we try overcome several obstacles clinical application cell secretome. A...
Abstract In recent years, autologous platelet‐rich plasma (PRP) derivatives have been used widely in the regeneration and repair of tissue, but a standard definition preparation method for PRP are lacking. We developed standardized using platelet indices as quality‐control indicators preparation. Twenty‐one elderly patients (9 males, 12 females) with complex wounds were treated (S‐PRP). The count after second centrifugation was 1,069–1,436 × 10 9 /L. adjusted concentration to 1,000 /L...
Abstract Objectives Histatin 1(Hst 1) has been proved to promote wound healing. However, there was no specific study on the regulation made by Hst 1 of fibroblasts in process This research comprehensively studied function healing and preliminary mechanism about it. Materials methods The full‐thickness skin model back C57/BL6 mice. healing, collagen deposition fibroblast distribution were detected days 3, 5 7 after injury. Fibroblast cultured vitro stimulated with 1, then, their biological...
Acellular dermal matrix (ADM) and platelet-rich plasma (PRP) have each been used in wound healing. There are a few reports on the application of ADM with PRP skin full-thickness defect models. In this study, microstructure ADM/PRP freeze-dried dressing was observed by scanning electron microscope. The PRP, PRP/ADM samples were recorded Fourier transform infrared (FTIR) spectrometer KBr methods. concentration growth factor measured enzyme-linked immunosorbent assay. Then, we made mice model...
BACKGROUND:Worldwide, the treatment of complications associated with type 2 diabetes mellitus, including diabetic foot ulcer (DFU), results in an economic burden for patients and healthcare systems. This study aimed to use high-throughput 16S rRNA gene sequencing investigate changes skin microbiome mellitus from a single center China. MATERIAL AND METHODS:Fifty-two participants were divided into 4 groups: healthy controls (n=13); short-term (<2 years; n=13); intermediate-term (5–8 long-term...
A rapid wound healing is beneficial for not only recovering aesthetics but also reducing pain, complications and healthcare burdens. Acellular dermal matrix (ADM) paste has been used to repair burn wounds shown promote angiogenesis as well fibroblast attachment migration. However, its efficacy still needs be significantly improved meet clinical demands. To approach this problem, we adopted a human salivary peptide — Histatin 1 (Hst1). Hst1 was chosen because of potency the adhesion,...
East Asian faces vary in shape but only oval seem to be considered attractive. Many patients with wide seek removal of part the mandibular angle and/or zygoma achieve an ideal facial contour, procedure is high risk and recovery period relatively protracted.We sought contours through use autologous fat grafting (AFG) combined masseter botulinum toxin (BTX) injection for hypertrophy.Fourteen underwent AFG forehead, temporal region, cheeks, zygomatic body, nose, nasolabial fold, tear trough,...
Abstract In the present study, age‐ and sex‐related differences in platelet ultrastructure were investigated using transmission electron microscopy (TEM). A total of 15 healthy volunteers grouped according to age, with 5 people each following groups: young group (25‐45 years), middle‐aged (46‐65 old‐aged (> 65 years). TEM micrographs, internal components, specifically α‐granules, dense granules, lysosomal 20 platelets counted for group. Two‐way analysis variance age sex was used compare...
Wound repair is accomplished by the interaction between cells involved in and extracellular matrix (ECM). Collagen main component of ECM, which transduction signal, transportation growth factors cytokines. Fibronectin (FN) also an important participates initiation fibroblast cell (FC) promotes adhesion, migration, proliferation differentiation target cells. Compared with natural protein, recombinant protein prepared artificial method has advantages poor immunogenicity, wide range sources,...
Abstract Background Acute skin wounds may compromise the barrier, posing a risk of infection. Small intestinal submucosa (SIS) is widely used to treat acute and chronic wounds. However, efficacy SIS accelerate wound healing still needs be improved meet clinical demands. To tackle this problem, platelet-rich plasma (PRP) due its potency promote proliferation, migration adhesion target cells. In study, we applied PRP explore their effects on by evaluating re-epithelialization, collagen...
Mesenchymal stem cell and 3D printing-based bone tissue engineering present a promising technique to repair large-volume defects. Its success is highly dependent on attachment, spreading, osteogenic differentiation, in vivo survival of cells 3D-printed scaffolds. In this study, we applied human salivary histatin-1 (Hst1) enhance the interactions adipose-derived (hASCs) β-tricalcium phosphate (β-TCP) bioceramic Fluorescent images showed that Hst1 significantly enhanced adhesion hASCs both...
Working memory is a central cognitive ability crucial for intelligent decision-making. Recent experimental and computational work studying working has primarily used categorical (i.e., one-hot) inputs, rather than ecologically relevant, multidimensional naturalistic ones. Moreover, studies have investigated during single or few tasks. As result, an understanding of how object information maintained in neural networks still lacking. To bridge this gap, we developed sensory-cognitive models,...
Acute skin injuries can result in the breakdown of barrier, heightening risk infections and complications. Histatin 1 (Hst1) promotes adhesion, spreading, migration various skin-related cells, thus encouraging wound healing. However, Hst1 is extensively degraded upon exposure to exudates. Cyclized hst1 (Cyclic-hst1) has a much higher resistance protease degradation than Hst1, increasing its stability half-life. Herein, we synthesized Cyclic-hst1 via click reaction explored efficacy healing...
Cross-linked hyaluronic acid (HA) is an active anti-aging cosmetic filler. The combination of cross-linked HA and preadipocytes or adipose-derived stem cells has been previously investigated, but the effects agglomerated injection on vascularization fat grafts remain unclear.The aim this study was to explore grafts.The backs nude mice were divided into 4 regions that received different treatments: nothing (control group), Biohyalux (HA (FAT lumps formed by sequential (HA/FAT group). Samples...
Objective To investigate the effect of a new front opening liposuction cannula on survival transplanted fat tissue. Methods Two groups fats were obtained from left and right sides female patient during abdomen surgery, respectively. And in experimental group control harvested by side hole cannula, The differences adipocyte activity vitro between 2 compared observation under electron scanning microscopy glucose transportation test. Then, ( n=20) injected subcutaneously into back 20 nude mice...
It has been reported that the beta-adrenergic receptor blocker (propranolol) and a-adrenergic (AR) (phentolamine) both can inhibit human endothelial cell (EC) angiogenesis in vitro. However, it is unknown whether this inhibition also acts on pericytes. The present study aimed to determine how pericytes react treatment with an a-/β- AR blocker. In study, proliferation assays scratch assay were performed assess effect of phentolamine or propranolol migration. Western blot ELISA employed...
ABSTRACT BACKGROUND Rapid estimation of the area chronic wounds is clinically important. A simple method using thumb was investigated for universal physical measurement, particularly small and multiple wounds; surface (TSA) then compared with total body (TBSA). METHODS cross-sectional observational study random sampling were used to obtain characteristics 343 participants. Data related handprint palm collected a scanner laptop assessed image software. The TSA as percentage TBSA confirmed...