A5015649809- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cancer-related molecular mechanisms research
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Coronary Interventions and Diagnostics
- MicroRNA in disease regulation
- Bone fractures and treatments
- RNA modifications and cancer
- Medical Imaging and Analysis
- Epigenetics and DNA Methylation
- Cardiovascular Health and Disease Prevention
- Pelvic and Acetabular Injuries
- Tissue Engineering and Regenerative Medicine
- Cancer-related gene regulation
- Anatomy and Medical Technology
- Orthopaedic implants and arthroplasty
- Functional Brain Connectivity Studies
- Orthopedic Surgery and Rehabilitation
- Hip and Femur Fractures
- Advanced Neuroimaging Techniques and Applications
- Bone Tissue Engineering Materials
- Virus-based gene therapy research
- Cardiac Imaging and Diagnostics
- Additive Manufacturing and 3D Printing Technologies
Southern Medical University
2016-2025
Guangdong Medical College
2020-2025
Third Affiliated Hospital of Southern Medical University
2020-2025
Fujian Medical University
2020-2025
University of South China
2024-2025
North University of China
2025
Huazhong University of Science and Technology
2016-2024
Tongji Hospital
2016-2024
Zhejiang Ocean University
2021-2024
Institute of Microbiology
2022-2024
Distal radius fracture is common in the general population. Fracture management includes a plaster cast, splint and synthetic material cast to immobilise injured arm. Casting complications are those conventional casting technologies. 3D printing technology rapidly increasing application rehabilitation. However, there no clinical study investigating of 3D–printed orthopaedic for treatment bone fractures. We have developed patient-specific fabricated by printing. This pioneering aims use casts...
Development of B cell memory is a conundrum that scientists are still exploring. Studies have been conducted in vitro and using advanced animal models to elucidate the mechanism underlying generation cells (MBCs), precise roles MBCs against pathogens, their protective functions repeated infections throughout life. Lifelong immunity invading diseases mainly result overcoming single infection. This protection largely mediated by two main components memory-MBCs long-lived plasma (PCs). The...
miR-155 plays critical roles in numerous physiological and pathological processes, however, its function the regulation of blood glucose homeostasis insulin sensitivity underlying mechanisms remain unknown. Here, we reveal that levels are downregulated serum from type 2 diabetes (T2D) patients, suggesting might be involved control diabetes. Gain-of-function loss-of-function studies mice demonstrate has no effects on pancreatic β-cell proliferation function. Global transgenic overexpression...
While scaffold-based tissue engineering has been widely used to treat bone critical-size defects, challenges such as implantation of scaffolds in defects with irregular shapes and through minimally invasive surgery remain the field. Customized bioactive reconfigurable capability for both easy scaffold perfect shape fitting irregularly shaped are therefore needed. Herein, applying 4D printing, photothermal-responsive memory constructed by incorporating black phosphorus nanosheets osteogenic...
Abstract Background CuS-modified hollow mesoporous organosilica nanoparticles (HMON@CuS) have been preferred as non-invasive treatment for cancer, near infrared (NIR)-induced photo-thermal effect (PTT) and/or photo-dynamic (PDT) could increase cancer cells’ apoptosis. However, the certain role of HMON@CuS-produced-PTT&PDT inducing gastric (GC) mitochondrial damage, remained unclear. Moreover, theranostic efficiency HMON@CuS might be well improved by applying multi-modal imaging, which...
Abstract Antiadhesive hydrogels have been developed for preventing the formation of postoperative adhesions. However, it is challenging to design an injectable hydrogel with superior tissue retention properties that can be easily administered during minimally invasive surgical procedures prevent development postsurgical In this study, asymmetric‐adhesive fabricated using photocurable catechol‐grafted hyaluronic acid (HAD) use The exhibits and favorably inhibits adhesion formation. This first...
Bone marrow mesenchymal stromal cell-derived exosomes (BMSC-Exos) can recruit stem cells for bone repair, with neovessels serving as the main migratory channel to injury site. However, existing exosome (Exo) delivery strategies cannot reach angiogenesis phase following injury. To that end, an enzyme-sensitive Exo material responds neovessel formation during was designed in present study achieve spatiotemporally controlled release. Herein, matrix metalloproteinase-1 (MMP1) found be highly...
Postsurgical pericardial adhesions pose increased risks of sequelae, prolonged reoperation time, and reduced visibility in the surgical field. Here, we introduce an injectable Janus hydrogel, which exhibits asymmetric adhesiveness properties after photocrosslinking, sustained delivering induced pluripotent stem cell–derived cardiomyocyte exosomes (iCM-EXOs) for post–heart surgery adhesion reduction. Our findings reveal that iCM-EXOs effectively attenuate oxidative stress hydrogen...
Cardiac safety assessments are significant in drug discovery, as drug-induced cardiotoxicity (DIC) is the primary cause of attrition. Despite heart-on-a-chip (HoC) technology becoming an increasingly popular tool for evaluating DIC, its development remains a challenge owing to anisotropic cardiac structure native myocardium. Herein, multiscale scaffold presented via hybrid biofabrication method by combining 3D printing with electrospinning technology, where 3D-printed micrometer-scale frames...
3D bioprinting of a gradient-stiffened gelatin–alginate hydrogel accelerated wound healing by promoting the proliferation, migration, and paracrine secretion encapsulated ADSCs.
Abstract To effectively treat osteoarthritis (OA), the existing inflammation must be reduced before cartilage damage can repaired; this cannot achieved with a single type of extracellular vesicles (EVs). Here, hydrogel complex logic‐gates function is proposed that spatiotemporally controlled release two types EVs: interleukin 10 (IL‐10) + EVs to promote M2 polarization macrophage, and SRY‐box transcription factor 9 (SOX9) increase matrix synthesis. Following dose‐of‐action screening, dual...
ABSTRACT The proliferation of CAR‐T cells was hindered and cannot play its killing function well in solid tumors. And yet the regulatory mechanism cell is not fully understood. Here, we showed that recombinant expression CD19CAR T significantly increased basal activation level LCK activation. Both SMAD4 were essential for since over‐express or promotes proliferation, while knock‐down inhibited seriously. More go into apoptosis when expression, cycle arrested G2/M S phase, respectively....