A5045070839- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Additive Manufacturing and 3D Printing Technologies
- Advanced Sensor and Energy Harvesting Materials
- Neuroscience and Neural Engineering
- Hydrogels: synthesis, properties, applications
- Intestinal and Peritoneal Adhesions
- Muscle Physiology and Disorders
- Extracellular vesicles in disease
- Pickering emulsions and particle stabilization
- Surgical Sutures and Adhesives
- Bone Tissue Engineering Materials
- Nerve injury and regeneration
- Hemostasis and retained surgical items
- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Reconstructive Facial Surgery Techniques
- Conducting polymers and applications
- Tendon Structure and Treatment
- Sports injuries and prevention
- Reconstructive Surgery and Microvascular Techniques
- Epigenetics and DNA Methylation
- Shoulder Injury and Treatment
- biodegradable polymer synthesis and properties
Southern Medical University
2019-2024
Key Laboratory of Guangdong Province
2020
Xi'an Jiaotong University
2014-2019
University of Hong Kong
2019
Hong Kong University of Science and Technology
2019
China XD Group (China)
2015
Frontier Science Foundation
2015
Institute of Science and Technology
2015
Mimicking the anisotropic cardiac structure and guiding 3D cellular orientation play a critical role in designing scaffolds for tissue regeneration. Significant advances have been achieved to control alignment elongation, but it remains an ongoing challenge engineering anisotropy using these approaches. Here, we present hybrid scaffold based on aligned conductive nanofiber yarns network (NFYs-NET, composition: polycaprolactone, silk fibroin, carbon nanotubes) within hydrogel shell mimicking...
Designing scaffolds that can mimic native skeletal muscle tissue and induce 3D cellular alignment elongated myotube formation remains an ongoing challenge for engineering. Herein, we present a simple technique to generate core–shell composite mimicking structure, which comprise the aligned nanofiber yarn (NFY) core photocurable hydrogel shell. The NFYs are prepared by hybrid composition including poly(caprolactone), silk fibroin, polyaniline via developed dry–wet electrospinning method. A...
Abstract Antiadhesive hydrogels have been developed for preventing the formation of postoperative adhesions. However, it is challenging to design an injectable hydrogel with superior tissue retention properties that can be easily administered during minimally invasive surgical procedures prevent development postsurgical In this study, asymmetric‐adhesive fabricated using photocurable catechol‐grafted hyaluronic acid (HAD) use The exhibits and favorably inhibits adhesion formation. This first...
Cardiac safety assessments are significant in drug discovery, as drug-induced cardiotoxicity (DIC) is the primary cause of attrition. Despite heart-on-a-chip (HoC) technology becoming an increasingly popular tool for evaluating DIC, its development remains a challenge owing to anisotropic cardiac structure native myocardium. Herein, multiscale scaffold presented via hybrid biofabrication method by combining 3D printing with electrospinning technology, where 3D-printed micrometer-scale frames...
Postsurgical pericardial adhesions pose increased risks of sequelae, prolonged reoperation time, and reduced visibility in the surgical field. Here, we introduce an injectable Janus hydrogel, which exhibits asymmetric adhesiveness properties after photocrosslinking, sustained delivering induced pluripotent stem cell–derived cardiomyocyte exosomes (iCM-EXOs) for post–heart surgery adhesion reduction. Our findings reveal that iCM-EXOs effectively attenuate oxidative stress hydrogen...
Abstract To effectively treat osteoarthritis (OA), the existing inflammation must be reduced before cartilage damage can repaired; this cannot achieved with a single type of extracellular vesicles (EVs). Here, hydrogel complex logic‐gates function is proposed that spatiotemporally controlled release two types EVs: interleukin 10 (IL‐10) + EVs to promote M2 polarization macrophage, and SRY‐box transcription factor 9 (SOX9) increase matrix synthesis. Following dose‐of‐action screening, dual...
Poly(glycerol sebacate) (PGS) has great potential for application in tissue engineering due to its good biocompatibility, tunable mechanical properties and controlled biodegradability. However, the complex thermal curing process poor water uptake capacity of PGS-based biomaterials limit their use directly cell encapsulation situ applications. We present novel injectable photocurable biodegradable hydrogels based on methacrylated poly(ethylene glycol)-co-poly(glycerol copolymers (PEGS-M),...
Injectable conducting hydrogels (ICHs) are promising conductive materials in biomedicine and bioengineering fields. However, the synthesis of ICHs previous work involved chemical cross-linking, this may result biocompatibility problems hydrogels. We present successful via noncovalent host–guest interactions, avoiding side effect covalent cross-linking. The based on γ-cyclodextrin dimer as host molecule tetraaniline poly(ethylene glycol) guests a synthetic well-defined hydrophilic copolymer....
Biodegradable poly(glycerol sebacate) (PGS) elastomers have received much attention as promising materials for potential applications in soft tissue repair and regeneration, due to their biomimetic viscoelastic properties. However, the low strength absence of bioactivity limited hard (bone, tooth, tendon ligament) regeneration. Here, we introduced molecular-level silica bioactive glass into matrix polymer prepare hybrid (PGSSC) bone regeneration applications. We shown here that our PGSSC...
Abstract Advancements in hydrogel bioadhesives for sealing gastrointestinal perforations (GP) face challenges due to weak mechanical properties, causing leakage, especially on uneven wound surfaces. Herein, a Janus is introduced featuring two‐step cross‐linking process, designed serve as an efficient bioadhesive using sprayable method. This formulation achieved by modifying photocurable hyaluronic acid with dopamine (DA) and phenylboronic (PBA) groups, enabling reversible boronate ester...