A5090988807- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Circular RNAs in diseases
- Human Motion and Animation
- Tissue Engineering and Regenerative Medicine
- Retinal Diseases and Treatments
- Bioactive Natural Diterpenoids Research
- Anesthesia and Neurotoxicity Research
- Neurological Disorders and Treatments
- Optical measurement and interference techniques
- Cardiac Ischemia and Reperfusion
- Social Robot Interaction and HRI
- Cholinesterase and Neurodegenerative Diseases
- Biological and pharmacological studies of plants
- Ocular Diseases and Behçet’s Syndrome
- Electrospun Nanofibers in Biomedical Applications
- Autophagy in Disease and Therapy
- Alzheimer's disease research and treatments
- Traditional Chinese Medicine Analysis
- Interactive and Immersive Displays
- Computational Drug Discovery Methods
- Advanced Vision and Imaging
- Neurological Disease Mechanisms and Treatments
- Mesenchymal stem cell research
TCM-Intigrated Cancer Center of Southern Medical University
2021-2024
Eye & ENT Hospital of Fudan University
2023
Zhongda Hospital Southeast University
2023
Fudan University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Introduction: The neurological impairment of survivors after ischemic stroke poses a serious risk to their quality life and health. Effective therapeutic options are still lacking. Neural stem cells (NSCs) promote neurogenesis via secreted extracellular vesicles (NSC-EVs), which would be potential option, but the insufficient quantity NSC-EVs in vivo restrains clinical application. Buyang Huanwu Decoction (BHD), classic traditional Chinese medicine (TCM) decoction, is promising alleviate...
Purpose: Pathologic myopia (PM) is one of the primary causes blindness. This study aims to explore possible relations between composition microRNA in vitreous exosomes patients with PM and progression myopic maculopathy. Methods: Vitreous humor (VH) samples were collected from undergoing retinal surgery. A total 15 12 VH obtained control, respectively. The group was divided into PM-L (G2) PM-H groups (G3 G4) order differentially expressed microRNAs (DEMs) that account for relatively poor...
Neural stem cell-derived extracellular vesicles (NSC-EVs) mediated endogenous neurogenesis determines a crucial impact on spontaneous recovery after stroke. Here, we checked the influence of Lycium barbarum polysaccharide (LBP) biogenesis NSC-EVs and then focused studying mechanisms LBP in ameliorating ischemic stroke outcome.LBP was prepared to precondition NSCs isolate EVs. MCAO models primary were administrated evaluate therapeutic effect. RT-PCR, western blot, flow cytometry,...
The middle cerebral artery occlusion model (MCAO) is one of the most common stroke models in neuroscience research. establishment mouse MCAO terms animal survival depends on anesthesia, which an important part entire surgical process. 7-day rate under isoflurane (ISO) anesthesia (35%) was lower than ketamine/xylazine (KX) (70%), demonstrated that success KX would be significantly higher ISO anesthesia. As confirmed by TTC staining and MRI, infarction area mice successfully modeled smaller...
Stroke is associated with a high disability and fatality rate, adversely affects the quality of life patients their families. Traditional Chinese Medicine (TCM) has been used effectively in treatment stroke for more than 2000 years China surrounding countries regions, over years, this field gleaned extensive clinical experience. The Phosphatidylinositol 3 kinase (PI3K)/ protein B (AKT) pathway important regulation cell migration, proliferation, differentiation, apoptosis, plays vital role...
Crowd Motion Generation is essential in entertainment industries such as animation and games well strategic fields like urban simulation planning. This new task requires an intricate integration of control generation to realistically synthesize crowd dynamics under specific spatial semantic constraints, whose challenges are yet be fully explored. On the one hand, existing human motion models typically focus on individual behaviors, neglecting complexities collective behaviors. other recent...
Human motion generation, a cornerstone technique in animation and video production, has widespread applications various tasks like text-to-motion music-to-dance. Previous works focus on developing specialist models tailored for each task without scalability. In this work, we present Large Motion Model (LMM), motion-centric, multi-modal framework that unifies mainstream generation into generalist model. A unified model is appealing since it can leverage wide range of data to achieve broad...
As a momentous condition disease, ischemic stroke could lead to physical disability and death. Here, the protective effect of miRNA up-regulated in neural stem cells (NSCs) derived exosomes on rats their molecular mechanisms were investigated reveal therapeutic target suggests new approaches treat stroke. miRNAs differentially expressed from NSCs at various differentiation stages detected by high-throughput sequencing for miRNAs. The impacts miR-9a-5p upregulation assessed NSCs. effects...