A5100385035- Neurogenesis and neuroplasticity mechanisms
- Anesthesia and Neurotoxicity Research
- Microtubule and mitosis dynamics
- Cellular Mechanics and Interactions
- Intensive Care Unit Cognitive Disorders
- Neuroscience and Neuropharmacology Research
- EFL/ESL Teaching and Learning
- Cardiac Ischemia and Reperfusion
- Neuroinflammation and Neurodegeneration Mechanisms
- biodegradable polymer synthesis and properties
- Genomic variations and chromosomal abnormalities
- RNA Research and Splicing
- Twentieth Century Scientific Developments
- Translation Studies and Practices
- Anesthesia and Sedative Agents
- Chromosomal and Genetic Variations
- Sleep and Wakefulness Research
- Axon Guidance and Neuronal Signaling
- Tissue Engineering and Regenerative Medicine
- Glioma Diagnosis and Treatment
- Higher Education and Teaching Methods
- Congenital Diaphragmatic Hernia Studies
- S100 Proteins and Annexins
- scientometrics and bibliometrics research
- Williams Syndrome Research
Johns Hopkins Medicine
2009-2024
Johns Hopkins University
2009-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2019-2022
TCM-Intigrated Cancer Center of Southern Medical University
2022
National University of Singapore
2019
Stowers Institute for Medical Research
2015-2016
Southern Medical University
2016
Nanfang Hospital
2016
Chongqing Medical University
2015
Sun Yat-sen University
2008
The polarity and organization of radial glial cells (RGCs), which serve as both stem scaffolds for neuronal migration, are crucial cortical development. However, the cytoskeletal mechanisms that drive outgrowth maintain RGC remain poorly understood. Here, we show Arp2/3 complex - unique actin nucleator produces branched networks plays essential roles in morphogenesis. Disruption murine RGCs retards process toward basal surface impairs apical adherens junctions. Whereas former is correlated...
Background Sleep deprivation (SD) plays a complex role in central nervous system (CNS) diseases. Recent studies indicate that short-term SD can affect the extent of ischemic damage. The aim this study was to investigate whether could stimulate hippocampal neurogenesis rat model global cerebral ischemia/reperfusion (GCIR). Methods One hundred Sprague-Dawley rats were randomly divided into Sham, GCIR and groups based on different durations SD; group three subgroups: GCIR+6hSD*3d-treated,...
Midazolam, a widely used anesthetic, inhibits proliferation of neural stem cells (NSCs) and induces neuroapoptosis in neonates. Dexmedetomidine, an effective auxiliary medicine clinical anesthesia, protects the developing brain against volatile anesthetic-induced neuroapoptosis. Whether dexmedetomidine neurogenesis damage induced by midazolam remains unknown. This study aims to clarify protective effect on midazolam-induced explore its potential mechanism. Postnatal 7-day-old Sprague-Dawley...
Exploring a strategy to effectively repair cerebral ischemic injury is critical requirement for neuroregeneration. Herein, we transplanted neural stem cell (NSC)-laden self-healing and injectable hydrogel into the brains of rats evaluated its therapeutic effects. We observed an improvement in neurological functions with NSC-laden hydrogel. This sufficiently efficient support neuroregeneration evidenced by NSC proliferation, differentiation, athletic movement recovery rats. effect relates...
The middle cerebral artery occlusion model (MCAO) is one of the most common stroke models in neuroscience research. establishment mouse MCAO terms animal survival depends on anesthesia, which an important part entire surgical process. 7-day rate under isoflurane (ISO) anesthesia (35%) was lower than ketamine/xylazine (KX) (70%), demonstrated that success KX would be significantly higher ISO anesthesia. As confirmed by TTC staining and MRI, infarction area mice successfully modeled smaller...
HIGHLIGHTS Disruption of the Arp2/3 complex impairs cortical development The promotes RGC basal process extension and apical adhesion Loss leads to altered polarity cell fate has non-cell-autonomous cell-autonomous roles in neuronal migration enables cells migrate on soft or less adhesive substrates SUMMARY organization radial glial (RGCs), which serve as both stem scaffolds for migration, are crucial development. However, cytoskeletal mechanisms that drive outgrowth maintain remain poorly...
The polarity and organization of radial glial cells (RGCs), which serve as both stem scaffolds for neuronal migration, are crucial cortical development.However, the cytoskeletal mechanisms that drive outgrowth maintain RGC remain poorly understood.Here, we show Arp2/3 complexthe unique actin nucleator produces branched networksplays essential roles in morphogenesis.Disruption complex murine RGCs retards process toward basal surface impairs apical adherens junctions.Whereas former is...
Cells employ protrusive leading edges to navigate and promote their migration in diverse physiological environments.Classical models of edge protrusion rely on a treadmilling dendritic actin network that undergoes continuous assembly nucleated by the Arp2/3 complex, forming ruffling lamellipodia.Although nucleation model has been rigorously evaluated several computational studies, experimental evidence demonstrating critical role for generation structures cell motility far from clear.Most...
Objective To research correlation factors and nursing measures for complication on perioperation in neonate-infants with congenital heart disease.Methods Strengthening the techniques preparation,to strict custodial care respiratory system function after operation,according to liquid manage tracheal intubation physiology characteristic.Results 49 cases had of lungs 228 group,that was 68.06%on total 71(31.14%) cases,2.19%cases died hospital,and difference statistical meaning(P<0.01) Contrast...
The ongoing trade war between the United States and China has led to questions about loyalty intent of Chinese American scientists. In this essay, I use my own small stories recall history generation scientists our journey in country build career life, all fewer than 1000 words. It intends be a tribute generosity spirit its openness strangers, which is very reason behind inexhaustible creativity world-leading research country.