A5047841976- Hydrogels: synthesis, properties, applications
- Nanoparticle-Based Drug Delivery
- Advanced Polymer Synthesis and Characterization
- Advancements in Battery Materials
- Essential Oils and Antimicrobial Activity
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Traditional Chinese Medicine Analysis
- biodegradable polymer synthesis and properties
- Wound Healing and Treatments
- Advanced Drug Delivery Systems
- Microencapsulation and Drying Processes
- Supercapacitor Materials and Fabrication
- Piperaceae Chemical and Biological Studies
- Polymer Surface Interaction Studies
- Cancer Cells and Metastasis
- Phytochemicals and Antioxidant Activities
- Electrochemical sensors and biosensors
- Pressure Ulcer Prevention and Management
- Cholinesterase and Neurodegenerative Diseases
- Phytochemistry and Biological Activities
- Surfactants and Colloidal Systems
- Nanocomposite Films for Food Packaging
- Eicosanoids and Hypertension Pharmacology
- Biochemical and biochemical processes
Xi'an Medical University
2013-2024
Shaanxi University of Science and Technology
2020-2023
Guangxi University
2021-2023
Sichuan Agricultural University
2020-2022
Tsinghua University
2002-2018
Shenzhen University
2018
St. John's University
1979
The effects of a new edible sodium alginate (SA) coating incorporating cinnamon essential oil nanocapsules (CEO-NPs) and nisin were investigated with beef slices in refrigerated storage for 15 days. All samples analyzed physicochemical properties (pH, weight loss, total volatile base nitrogen) antimicrobial activity against bacteria. Changes color parameters sensory attributes all also evaluated. Incorporation the complex CEO-NPs into SA retarded growth microorganisms reduced lipid...
β-Lapachone (LPC) is a novel cytotoxic agent that bioactivated by NADP(H): quinone oxidoreductase 1 (NQO1), an enzyme elevated in variety of tumors, such as non-small cell lung cancer (NSCLC), pancreatic cancer, liver and breast cancer. Despite its unique mechanism action, clinical evaluation has been largely hindered low water solubility, short blood half-life, narrow therapeutic window. Although encapsulation into poly(ethylene glycol)-b-poly(D,L-lactic acid) (PEG-PLA) micelles could...
Itraconazole (ITA), an old and widely prescribed antifungal drug with excellent safety profile, has more recently been demonstrated to be a multitarget antiangiogenesis agent affecting multiple angiogenic stimulatory signals pathways, including vascular endothelial growth factor (VEGF), basic fibroblast (bFGF), receptor 2 (VEGFR2) glycosylation, mammalian target of rapamycin (mTOR). In this study, we developed two nanoparticle formulations, i.e., polymer micelles (IP2K) albumin nanoparticles...
To solve the problems associated with poorly water-soluble nonsteroidal anti-inflammatory drugs (NSAIDs), naproxen-based ionic liquids (ILs) containing naproxen as an active pharmaceutical ingredient (API) anion were prepared benzalkonium (tetradecyldimethylbenzyl ammonium), choline, and 1-octyl-3-methylimidazole cation. The structures thermal properties analyzed. Through conductivity method, solubility at 25 37 °C critical micelle concentration (CMC) determined in water ethanol....
Abstract Although polymeric micelles of paclitaxel (PTX) significantly reduce excipient‐induced toxicity compared with Taxol, they exhibit few clinical advantages in tumor inhibition and overall survival. To improve, itraconazole (ITA), an antifungal drug potent anti‐angiogenesis activity, is co‐encapsulated together PTX within the PEG‐PLA micelles. The strong intermolecular interactions between payloads inhibit crystallization prevent drugs from binding external proteins, render...
Tough gel with extreme temperature tolerance is a class of soft materials having potential applications in the specific field required excellent integrated properties under subzero temperature. Herein, physical crosslinked Eueopian (Eu)-alginate/polyvinyl alcohol (PVA) organohydrogels that do not freeze at far below 0°C, while retention high stress and stretchability demonstrated. These are synthesized through displacement water swollen polymer networks hydrogel to cryoprotectants (e.g.,...
Piperine was used in this study its raw form, and different steps, such as amide hydrolysis amidation, were to synthesize piperine derivatives containing a phenolic hydroxyl group. DPPH ABTS free radical scavenging assays assess derivative antioxidant activities. We constructed an AAPH oxidative stress erythrocyte model the effect of on hemolysis rate oxidatively damaged erythrocytes well hemoglobin oxidation rate. This also determine effects enzyme activity malondialdehyde (MDA) content....
Severely chronic dermal wounds with irregular rupture shapes or even cavities are calling for injectable and self-biodegradable wound dressings skin lesion complex contours remain a great challenge. Here, we report an injectable, poly(aspartic acid)-l-poly(aspartyl hydrazide) (PASP-l-PAHy) hydrogel to address these issues. The starting materials were cheap, the new strategy fabrication of acid) based was facile, efficient, mild environmentally friendly, which is consistent concept green...
The underlying mechanism of the myocardial protective effect fisetin was studied in a rat ischemia/reperfusion injury model. Sprague-Dawley rats were randomly assigned to seven groups and pretreated with different solutions by gavage administration. A model cardiac established. Plasma levels Von Willebrand factor (vWF) determined ELISA, flow cytometry used determine level cardiomyocyte apoptosis 2,3,5-triphenyltetrazolium staining size infarcts. Hematoxylin eosin-stained sections tissues...
DAPB, a new molecule including danshensu, borneol, and mother nucleus of ACEI (Angiotensin-converting enzyme inhibitors), is being developed as an antihypertensive candidate compound. A rapid, accurate, sensitive ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was established validated for the determination DAPB in rat plasma. Chromatographic separation performed on Agilent SB-C18 column after protein precipitation by acetonitrile with mobile phase...
Piperine amino acid derivatives containing phenolic hydroxyl groups were synthesized using piperine as the raw material by amide hydrolysis, amidation, ester and deacetalization. The obtained products characterized mass spectrometry nuclear magnetic resonance. antioxidant activity of was evaluated DPPH ABTS scavenging rates total capacity. results showed that ( 4a – 4d ) had relatively weak radical-scavenging ability, while 5a 5d significant effects. In addition, reducing ability better than...
ABSTRACT A novel dual‐responsive (light and pH) particle based on poly(methacrylic acid), acid)–poly[1‐(2‐nitrophenyl)ethane‐1,2‐diyl bis(2‐methylacrylate)]was prepared with the facile method of two‐step homogeneous radical polymerization methacrylic acid as monomer 1‐(2‐nitrophenyl)ethane‐1,2‐diyl bis(2‐methylacrylate) a photodegradable crosslinker. Photolytic assessments were conducted upon irradiation UV lamp; this led to disintegration caused by cleavage photolabile crosslinking points....
Exploring a strategy to effectively repair cerebral ischemic injury is critical requirement for neuroregeneration. Herein, we transplanted neural stem cell (NSC)-laden self-healing and injectable hydrogel into the brains of rats evaluated its therapeutic effects. We observed an improvement in neurological functions with NSC-laden hydrogel. This sufficiently efficient support neuroregeneration evidenced by NSC proliferation, differentiation, athletic movement recovery rats. effect relates...
Hypertension is the main risk factor of cardiovascular and cerebrovascular diseases. In this paper, a novel compound known as 221s (2,9), which includes tanshinol, borneol mother nucleus ACEI, was synthesized by condensation esterification, deprotection, amidation, with initial raw material, using strategy combinatorial molecular chemistry. The structure confirmed 1H NMR, 13C high-resolution mass spectrometry, purity more than 99.5%. (2,9) can significantly reduce systolic diastolic blood...