A5017404634- Synthesis and properties of polymers
- Epoxy Resin Curing Processes
- Silicone and Siloxane Chemistry
- Cancer Research and Treatments
- Bone and Dental Protein Studies
- Fatty Acid Research and Health
- Cancer, Hypoxia, and Metabolism
- Click Chemistry and Applications
- Advanced ceramic materials synthesis
- Adipose Tissue and Metabolism
- Seaweed-derived Bioactive Compounds
- Membrane Separation Technologies
- Synthesis and characterization of novel inorganic/organometallic compounds
- Machine Learning in Materials Science
- Injection Molding Process and Properties
- Echinoderm biology and ecology
- Synthesis of Tetrazole Derivatives
- Organoboron and organosilicon chemistry
- Chemical Synthesis and Analysis
- Soil Carbon and Nitrogen Dynamics
- Thermal and Kinetic Analysis
- MXene and MAX Phase Materials
- Advanced biosensing and bioanalysis techniques
- Gut microbiota and health
- Membrane-based Ion Separation Techniques
Xuzhou Medical College
2022-2025
Sichuan University
2022-2025
West China Hospital of Sichuan University
2022-2025
East China University of Science and Technology
2013-2024
National University of Singapore
2024
Zunyi Medical University
2022-2024
Shandong University
2019-2024
Dalian University of Technology
2016-2024
Jinan Central Hospital
2022-2024
Guangzhou University
2024
ConspectusPolymeric material research is encountering a new paradigm driven by machine learning (ML) and big data. The ML-assisted design has proven to be successful approach for designing novel high-performance polymeric materials. This goal mainly achieved through the following procedure: structure representation database construction, establishment of ML-based property prediction model, virtual high-throughput screening. key this lies in training ML models that delineate...
Incorporation of a guanidine functional group into the PNA backbone facilitates cellular uptake mammalian cells with efficiency comparable to that TAT transduction domain. The modified recognizes and binds complementary DNA strand in accordance Watson−Crick recognition rules. However, unlike polypyrimidine which 2:1 stoichiometry, 1:1 ratio form highly stable duplex.
We demonstrate that tuning the stereo-hindrance of phenoxy-alkyl chains at 4-position a curcumin scaffold could lead to certain selectivity for soluble Aβs over insoluble Aβs.
In this study, we systematically investigated the effect of different phosphatidylcholines on high fat diet-induced insulin resistance in mice.
The gut-microbiota-brain axis is the most important complex and bidirectional pathway between gastrointestinal tract central nervous system. This study investigated potential of microbe-induced gut-to-brain signaling to modulate effect stress on depressive-like behavior, intestinal barrier, neuroinflammation. Result showed that fecal microbiota transplantation increased consumption sucrose solutions decreased immobility time in forced swimming test. treatment also Firmicutes Bacteroidetes...
Despite advances in machine learning for accurately predicting material properties, forecasting the performance of thermosetting polymers remains a challenge due to sparsity historical experimental data and their complicated crosslinked structures. We proposed machine-learning-assisted materials genome approach (MGA) rapidly designing novel epoxy thermosets with excellent mechanical properties (high tensile moduli, high strength, toughness) through high-throughput screening vast chemical...
The purpose of this study was to evaluate the preventive role and underlying mechanisms fucoxanthin (Fx) on dextran sulfate sodium (DSS)-induced colitis in mice. present data demonstrated that oral administration Fx (50 200 mg/kg body weight/day) for 36 days significantly alleviated severity DSS-treated mice, as evidenced by attenuating weight loss, bloody stool, diarrhea, shortened colon length, colonic epithelium distortion, a thin mucus layer, goblet cell depletion, damaged crypts,...
Alzheimer's disease (AD) is a common neurodegenerative disorders, in which oxidative stress plays an important role. The present study investigated the effect of eicosapentaenoic acid-enriched phospholipids (EPA-enriched PL) from sea cucumber Cucumaria frondosa on injury PC12 cells induced by hydrogen peroxide (H2O2) and tert-butylhydroperoxide (t-BHP). We also studied EPA-enriched PL learning memory functions senescence-accelerated prone mouse strain 8 (SAMP8) vivo. Pretreatment with...
Designing high-temperature polymers with excellent processability is a long-standing challenge because of the implacable contradiction between high thermal stability and low curing energy. Traditional designs based on scientific intuition trial-and-error experiments have not been efficient strategies for discovery new heat-resistant resins. In this work, we developed materials genome approach to facilitate design resins desired properties. By defining gene extracting key features properties,...
Based on the workflow of materials genome approach, challenge enhancing multiple conflicting properties an advanced thermosetting polymer polycyanurates was addressed through high-throughout screening using machine learning.