A5100420469- Gut microbiota and health
- Food composition and properties
- Microbial Metabolites in Food Biotechnology
- Pain Mechanisms and Treatments
- Polysaccharides and Plant Cell Walls
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Animal Nutrition and Physiology
- Polysaccharides Composition and Applications
- Phytochemicals and Antioxidant Activities
- Neuroscience and Neuropharmacology Research
- Proteins in Food Systems
- Probiotics and Fermented Foods
- Sirtuins and Resveratrol in Medicine
- Fungal Biology and Applications
- Nanocomposite Films for Food Packaging
- Muscle Physiology and Disorders
- Cancer Immunotherapy and Biomarkers
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Food Quality and Safety Studies
- Meat and Animal Product Quality
- Biochemical Analysis and Sensing Techniques
- Ion channel regulation and function
- Gastrointestinal motility and disorders
Chinese Academy of Agricultural Sciences
2006-2025
Sichuan Agricultural University
2016-2025
Ministry of Agriculture and Rural Affairs
2023-2025
Oil Crops Research Institute
2006-2025
University of Michigan
2023-2025
The University of Texas MD Anderson Cancer Center
2013-2024
Jilin Agricultural University
2024
Sichuan University
2024
Rangsit University
2024
Washington University in St. Louis
2024
α2δ-1, commonly known as a voltage-activated Ca2+ channel subunit, is binding site of gabapentinoids used to treat neuropathic pain and epilepsy. However, it unclear how α2δ-1 contributes gabapentinoid actions. Here, we show that Cacna2d1 overexpression potentiates presynaptic postsynaptic NMDAR activity spinal dorsal horn neurons cause hypersensitivity. Conversely, knockdown or ablation normalizes synaptic increased by nerve injury. forms heteromeric complex with NMDARs in rodent human...
Gelatin/polycrylamide double-network (DN) hydrogels composed of two different polymer networks with strong asymmetry are excellent structural platforms to integrate mechanical properties into a single material.
Cytotoxic lymphocyte antigen-4 (CTLA-4) blockade is an active immunotherapeutic strategy that currently in clinical trials cancer. There are several ongoing of anti-CTLA-4 the metastatic setting prostate cancer patients with reported responses consisting decreases specific antigen (PSA) tumor marker for some patients. Immunologic markers correlate these necessary to guide further development therapy treatment We recently CD4(+) inducible co-stimulator (ICOS)(hi) T cells produce...
Opioids remain the mainstay of treatment for severe pain, but associated hyperalgesia and tolerance are significant impediments to achieving adequate pain relief with opioids. Here we show that in spinal cord, brief application μ-opioid receptor agonist (D-Ala 2 ,N-Me-Phe 4 ,Gly-ol 5 )-enkephalin (DAMGO) at 1 μ m , not 1–10 n caused an initial decrease followed by a large long-lasting increase amplitude monosynaptic EPSCs evoked from dorsal root ∼50% lamina I II neurons. However,...
The objective of this study was to compare the effects micronization (MT), steam explosion (SE), and gamma irradiation (GI) treatment on chemical composition, structure, physicochemical properties, in vitro digestibility dietary fiber from soybean hulls. GI (1200 kGy) exerted optimum improving soluble content, gross energy (IVGED), reducing sugar yield (RS) three modification methods, increased by 342.88%, 55.24%, 117.02%, respectively. Compared with treatment, MT-GI combined could further...
Abstract Background Previous studies have shown that exogenous short-chain fatty acids (SCFAs) introduction attenuated the body fat deposition in conventional mice and pigs. However, limited evaluated effects of exogenously introduced SCFAs on lipid glucose metabolism independently gut microbiota. This study was to investigate a germ-free (GF) pig model. Methods Twelve hysterectomy-derived newborn pigs were reared six sterile isolators. All hand-fed with milk powder for 21 d, then feed...
Phyllanthus emblica L. (PE) is commonly known as a medicine and food homologous plant, which abundant in natural products polyphenols. In the present study, polyphenols were extracted from PE fruit by response surface method, anti-aging ability was determined. exhibited strong antioxidant capacities scavenging free radicals, anti-cholinesterase inhibition of AChE (IC50 0.2186 ± 0.0416 mg/mL) BuChE 0.0542 0.0054 vitro. Moreover, showed protective effect against aging process Caenorhabditis...
In recent years, the function of plant polyphenols to improve intestinal barrier has been fully demonstrated. However, exact mechanisms linking with have not yet established. Apple (APs) are safe and healthy nutrients, which extracted from apples their byproducts. Using pig IPEC-J2 cell models, this study investigated effects dietary AP supplementation on antioxidant capacity function. Then, we further explored role Nrf2/Keap1 signaling pathway in maintaining Our found that improved...
In this research, the different methods (acid extraction, alkaline extraction and enzymatic extraction) were used to extract soluble dietary fiber (SDF) from pomegranate peel compared with water extraction. Results revealed that all three influenced structure, physicochemical functional properties of SDF. Especially, SDF extracted by enzymes (E-SDF) alkali (A-SDF) had higher yield (27.30% 27.17%), molecular weight thermal stability than (W-SDF). Higher oil holding capacity (OHC) was found in...