A5064650060- Tuberculosis Research and Epidemiology
- Parasitic infections in humans and animals
- Natural product bioactivities and synthesis
- Parasitic Infections and Diagnostics
- Mycobacterium research and diagnosis
- Pharmacological Effects of Natural Compounds
- Bioactive natural compounds
- Immune Response and Inflammation
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Parasites and Host Interactions
- Immunodeficiency and Autoimmune Disorders
- Innovative Teaching Methods
- Congenital Anomalies and Fetal Surgery
- Problem and Project Based Learning
- Amoebic Infections and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune responses and vaccinations
- Ideological and Political Education
- Phytochemicals and Antioxidant Activities
- Biological Activity of Diterpenoids and Biflavonoids
- Moringa oleifera research and applications
- Cancer-related molecular mechanisms research
- Smart Grid Energy Management
- Essential Oils and Antimicrobial Activity
Xihua University
2021-2024
Qinghai Institute for Endemic Diease Prevention and Control
2024
Lanzhou University
2013-2022
Qinhuangdao Second Hospital
2021
Xi'an Medical University
2020
Gansu Provincial Hospital
2012
Institute of Animal Reproduction and Food Research
2011
Polish Academy of Sciences
2011
State Key Laboratory of Fire Science
2011
Sinopec (China)
2007
Although the teaching methods of blended learning and BOPPPS (bridge-in, objective, preassessment, participatory learning, postassessment, summary) model are proven to be successful highly effective at improving academic knowledge students, respectively, it is unclear whether combined with (BL-BOPPPS) could work well in an introduction course health services management (HSM) for students China. The study investigated perceptions effects implementing BL-BOPPPS on student outcomes HSM....
To search for more effective tuberculosis (TB) subunit vaccines, antigens expressed in different growth stages of Mycobacterium (M. tuberculosis), such as RpfE (Rv2450c) produced the stage resuscitation, Mtb10.4 (Rv0288), Mtb8.4 (Rv1174c), ESAT6 (Rv3875), Ag85B (Rv1886c) mainly secreted by replicating bacilli, and HspX (Rv2031c) highly dormant were selected to construct six fusion proteins: ESAT6-Ag85B-MPT64190-198-Mtb8.4 (EAMM), Mtb10.4-HspX (MH), ESAT6-Mtb8.4, Mtb10.4-Ag85B, ESAT6-Ag85B,...
Tuberculosis (TB) is a chronic disease mainly caused by Mycobacterium tuberculosis. The function of T cells usually decreased and even exhausted in severe TB such as multiple drug resistant (MDR-TB), which might lead to the failure treatment return. mechanism cell dysfunction still not clear. In this study we set up mouse model persistent M. tuberculosis antigen stimulation investigated therapeutic role interleukin 2 (IL-2) it. C57BL/6 mice were primed with bovis Bacillus Calmette-Guérin...
Background Cystic echinococcosis (CE), a zoonosis caused by Echinococcus granulosus sensu lato (EG), is major public health burden in western China. The study aimed to evaluate the current status of KAP about CE among undergraduate students from areas China, and provide basis for developing education strategies college on prevention CE. Methods A cross-sectional was conducted September 2023 April 2024 cluster sampling method used enroll participants students. Cronbach’s alpha coefficient...
The echinococcosis of humans and animals is a chronic helminthic disease caused by the larva genus Echinococcus tapeworms. It globally distributed which an important socioeconomic public health problem in many low middle-income countries. This research aimed to firstly quantitatively analyze publications with bibliometrics software evaluated hot topics emerging trends from 1980 2017. A total 7688 references on were retrieved Web Science Core Collection database. Then reference was analyzed...
Three new phytochemicals, a polyacetylene, 1,2-dihydrodendroarboreol B (1), an ionone derivative, (3S,5R,6S,7E)-3-tetradecanoate-5,6-epoxy-β-ionone (4), and flavonol diglycoside, quercetagetin-3,6,4′-trimethoxy-7-O-neohesperidoside (38), along with 35 known compounds diverse structures, were isolated from the EtOH extract of aerial parts Tridax procumbens. The structures 1, 4, 38 determined on basis comprehensive methods including UV, IR, NMR, HR-ESI-MS, CD, by comparison spectroscopic data...
The underlying mechanism of the myocardial protective effect fisetin was studied in a rat ischemia/reperfusion injury model. Sprague-Dawley rats were randomly assigned to seven groups and pretreated with different solutions by gavage administration. A model cardiac established. Plasma levels Von Willebrand factor (vWF) determined ELISA, flow cytometry used determine level cardiomyocyte apoptosis 2,3,5-triphenyltetrazolium staining size infarcts. Hematoxylin eosin-stained sections tissues...
Context: Gastric cancer remains highly prevalent, but treatment options are limited. Natural products have proved to be a rich source of anticancer drugs. Chrysosplenium nudicaule Ledeb. (Saxifragaceae) is perennial herb that grows in the highlands China. It has been used as traditional Chinese medicine treat digestive diseases for hundreds years. Recent studies revealed this had activity, and flavonoids were speculated effective components. 6,7,3′-Trimethoxy-3,5,4′-trihydroxy flavone (TTF)...
Novel compounds and more efficient treatment options are urgently needed for the of cystic echinococcosis (CE), which is caused by Echinococcus granulosus. The decoction Sophora moorcroftiana (Fabaceae) has been used to treat parasitosis years in traditional Tibetan medicine. aim this study was screen insecticidal water-soluble alkaloids from S. seeds evaluate therapeutic effects against CE immune response induced alkaloidal fraction. Low polarity (E2-a) were isolated alkaloid (E2) matrine...
Abstract Background: Case-based learning (CBL), an educational method of problem-based learning, provides students with a venue to relate content learned in the classroom performance professional practice. This study compared CBL teaching clinical laboratory immunology (CLI) course lecture-based (LBL), and evaluated effect on regarding CBL. Methods: Data were collected from senior (n=85; 46% males, 54% females) at Lanzhou University China. The divided into two groups, one group was offered...
Previous studies have shown that the ethanolic extracts from Sophora moorcroftiana seeds (ee-Sms) in vitro anticancer properties. The anti-proliferation effects of ee-Sms on HepG2 cells were assessed by MTT assay and cell cycle analysis. Total proteins separated two-dimensional electrophoresis (2-DE), protein spots with more than two-fold difference analysed MALDI-TOF/TOF-MS. showed demonstrates dose- time dependently. treated at 1.30 mg/mL for 48 h induced arrest S phase....
1β-hydroxy alantolactone, a sesquiterpene lactone mainly isolated from Inula genus plants, exhibits potent anti-inflammatory and anticancer activities. In this work, alantolactone was five derivatives were prepared through different reactions at the C1-OH C13-methylene motifs. The structure-activity relationships (SAR) of effects against NO production in RAW264.7 cells showed that α-methylene-γ-butyrolactone motif essential for suppression retaining group can remarkably improve effect. NF-κB...
Abstract Regulatory T cells (Tregs), which could be down-regulated by IL-28B, were reported to suppress T-cell-mediated immunity. The aim of this study was investigate the role IL-28B on immune responses and protective efficacy a tuberculosis (TB) subunit vaccine. First, recombinant adenoviral vector expressing mouse (rAd-mIL-28B) constructed; then C57BL/6 mice immunized with vaccine ESAT6-Ag85B-Mpt64 (190–198) -Mtb8.4-HspX (EAMMH) rAd-mIL-28B together thrice or primed Mycobacterium bovis...
The application-based flipped classroom (APP-FC) is an innovative teaching-learning model that has not been applied and assessed in basic medical curricula teaching China. aim of this investigation to assess students’ perceptions the APP-based immunology course. data study were collected from second-year students (n = 92) at Lanzhou University. One class 50), as a control group, was offered lecture-based learning (LBL), while other 42), APP-FC given instruction during September–November...
Abstract Human cystic echinococcosis is a widespread, chronic, endemic, helminthic zoonosis caused by larval tapeworms of the species Echinococcus granulosus. At present, there no rational and effective therapy for patients with echinococcosis. The present study evaluated whether combination alkaloids from Sophora moorcroftiana seeds (SMSa2) Bacillus Calmette–Guérin (BCG) was in treatment experimental After 20 weeks secondary infection protoscoleces, mice were randomly allocated to five...