A5101666166- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Liver Disease Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Renal Diseases and Glomerulopathies
- MRI in cancer diagnosis
- Parathyroid Disorders and Treatments
- Gout, Hyperuricemia, Uric Acid
- Artificial Intelligence in Healthcare
- Cardiovascular Function and Risk Factors
- Metabolomics and Mass Spectrometry Studies
- Tuberculosis Research and Epidemiology
- Erythropoietin and Anemia Treatment
- Cardiovascular Health and Disease Prevention
- Traditional Chinese Medicine Studies
- Acute Kidney Injury Research
- Genomics and Phylogenetic Studies
- Advanced Battery Technologies Research
- Pancreatitis Pathology and Treatment
- MicroRNA in disease regulation
- Diet and metabolism studies
- Fault Detection and Control Systems
- Heart Failure Treatment and Management
- Advanced biosensing and bioanalysis techniques
- Immune Response and Inflammation
Third Affiliated Hospital of Sun Yat-sen University
2015-2024
Sun Yat-sen University
2015-2024
George Washington University
2024
China Medical University
2023
Shanghai Institute of Measurement and Testing Technology
2023
Fifth Tianjin Central Hospital
2020-2022
Weifang People's Hospital
2018-2022
University of Virginia
2021
Qingdao University of Science and Technology
2021
Chimie Biologique pour le Vivant
2021
A non-dipper blood pressure (BP) pattern is very common in chronic kidney disease (CKD) patients and affects the progression development of cardiovascular disease. However, data on reversed dipper BP target-organ damage Chinese CKD are lacking.A total 540 were enrolled. Ambulatory monitoring (ABPM), clinical BP, ultrasonographic assessment other collected. Univariate multivariate analyses used to ascertain relationship between ABPM results parameters.A 21.9% had a pattern, 42% 36.1% pattern....
Cell-free microRNAs stably and abundantly exist in body fluids emerging evidence suggests cell-free as novel non-invasive disease biomarker. Deregulation of miR-29 is involved the pathogenesis diabetic nephropathy insulin resistance thus may be implicated vascular complication. Therefore, we investigated possibility urinary biomarker for atherosclerosis patients with type 2 diabetes.83 diabetes were enrolled this study, miR-29a, miR-29b miR-29c levels urine supernatant was determined by...
Importance Youth-onset type 2 diabetes is associated with poor glycemic control and early onset of complications. Identification psychosocial factors needed to inform efficacious interventions. Objective To identify glycated hemoglobin (HbA 1c ) levels in young adults youth-onset diabetes. Design, Setting, Participants For the i Count cohort study, HbA were measured twice (at baseline [T1] at 1 year [T2]) during last years (2017-2019) observational phase multicenter Treatment Options for...
Protein sequence profile prediction aims to generate multiple sequences from structural information advance the protein design. can be computationally predicted by energy-based or fragment-based methods. By integrating these methods with neural networks, our previous method, SPIN2, has achieved a recovery rate of 34%. However, SPIN2 employed only one-dimensional (1D) properties that are not sufficient represent three-dimensional (3D) structures. In this study, we represented 3D structures 2D...
Abstract The African swine fever virus (ASFV) has caused severe economic losses in the pig industry. To monitor ASFV spread, p30 protein been identified as an ideal infection marker due to its early and long-term expression during period. Timely monitoring of enables detection assessment disease progression. Aptamers are outstanding substitute for antibodies develop efficient tool detection. In this study, a series aptamer candidates were screened by vitro magnetic bead-based systematic...
Background Endothelial dysfunction is an early sign of diabetic cardiovascular disease and may contribute to progressive nephropathy (DN). There increasing evidence that the endothelial tight junction a crucial step in development hyperpermeability, but it unknown whether this occurs glomerular cells (GEnCs) during progression DN. We examined GEnCs early-stage DN potential underlying mechanisms. also effect simvastatin (3-Hydroxy-3-methylglutaryl CoA reductase inhibitor) on junctions...
// Xilian Qiu 1, * , Chunyong Liu 2, Yuqiu Ye 3, Huiqun Li 3 Yanbing Chen 4 Yongmei Fu Zhenjie 2 Xianzhang Huang Yunqiang Zhang 5 Xueyuan Liao Hongyong 5, Wenbo Zhao and Xun 1 Department of Laboratory Medicine, The First Affiliated Hospital Sun Yat-sen University, Guangzhou, China Second Guangzhou University Traditional Chinese Nephrology, Third Medical genetic center, Guangdong Women And Children Hospital, Guangdong, Division 3rd Yuedong Meizhou, These authors contributed equally to this...
To investigate the distribution of diabetic retinopathy (DR) by sex in patients with type 2 diabetes mellitus (T2DM) a twelve-province cross-sectional study China. Patients T2DM, whose ages were ≥18 years, recruited from 76 cities/counties 12 provinces mainland China between January 2015 and December 2018. All participants received standardized interview, eye examinations, digital fundus photography. The presence severity DR diagnosed classified retina specialists according to domestic...
BACKGROUND:Thyroid nodules are extremely common and typically diagnosed with ultrasound whether benign or malignant. Imaging diagnosis assisted by Artificial Intelligence has attracted much attention in recent years. The aim of our study was to build an ensemble deep learning classification model accurately differentiate malignant thyroid nodules. MATERIAL AND METHODS:Based on current advanced methods image segmentation algorithms, we proposed for (EDLC-TN) after precise localization. We...
The aim of this study was to construct a deep convolutional neural network (CNN) model for localization and diagnosis thyroid nodules on ultrasound evaluate its diagnostic performance.We developed trained CNN called the Brief Efficient Thyroid Network (BETNET) using 16,401 images. According parameters model, we computer-aided (CAD) system localize differentiate nodules. validation dataset (1,000 images) used compare performance three state-of-the-art algorithms. We an internal test set (300...
Background Type 4 cardiorenal syndrome ( CRS ) refers to the cardiac injury induced by chronic kidney disease. We aimed assess oxidative stress and in patients with type , determine whether antioxidant apocynin attenuated rats explore potential mechanisms. Methods Results A cross‐sectional study was conducted among (n=17) controls (n=16). Compared controls, showed elevated stress, which significantly correlated hypertrophy decreased ejection fraction. In vivo study, male Sprague‐Dawley...
Abstract Background Sirtuin 3 (Sirt3) is a key regulator of energy metabolism and oxidative stress. To investigate the role Sirt3 in contrast-induced acute kidney injury (CIAKI), we established model both vivo vitro to explore potential mechanisms. Methods In vivo, CIAKI models wild-type (WT) Sirt3-knockout (Sirt3-KO) mice. Blood urea nitrogen (BUN) serum creatinine (Scr) were detected by enzyme-linked immunosorbent assay, Glomerular Filtration Rate (GFR) clearance also investigated. We...
Abstract Background Chronic kidney disease (CKD) is a global public health issue. The diagnosis of CKD would be considerably enhanced by discovering novel biomarkers used to determine the glomerular filtration rate (GFR). Small molecule metabolites related function that might utilized as measure GFR more accurately could found via metabolomics analysis blood samples taken from individuals with varied rates. Methods An untargeted study 145 plasma was performed using ultrahigh-performance...
Nondipping blood pressure (BP) pattern is a potential independent risk factor for chronic kidney disease (CKD). Bedtime administration of valsartan considered to normalize circadian rhythm and protect the kidneys heart in CKD patients. However, more clinical trials are needed confirm this benefit. Sixty patients with nondipping BP thirty dipping were enrolled study, randomly divided into two groups treated bedtime or awakening doses (80–320 mg). showed greater reduction 24‐hour proteinuria...
Background We sought to develop a new equation estimate glomerular filtration rate (GFR) in Chinese elderly population. Methods A total of 668 participants, including the development cohort (n = 433), validation 235) were enrolled. The using generalized additive model, and age, gender, serum creatinine as predictor variables was developed performances compared with CKD-EPI equation. Results In data set, both bias precision improved equation, (median difference, −1.5 ml/min/1.73 m2 vs. 7.4...
Effective tuberculosis (TB) vaccine should target tubercle bacilli with various metabolic states and confer long-term protective immunity. In this study, we constructed a novel multi-stage TB subunit based on fusion protein ESAT6-Ag85B-MPT64(190-198)-Mtb8.4-HspX (LT69 for short) which combined early expressed antigens latency-associated antigen. The was mixed an adjuvant being composed of N, N'-dimethyl-N, N'-dioctadecylammonium bromide (DDA) polyriboinosinic polyribocytidylic acid (PolyI:C)...