A5009648508- Chronic Kidney Disease and Diabetes
- Cancer Immunotherapy and Biomarkers
- Renal Diseases and Glomerulopathies
- Suicide and Self-Harm Studies
- Liver Disease Diagnosis and Treatment
- Folate and B Vitamins Research
- Child and Adolescent Psychosocial and Emotional Development
- Attention Deficit Hyperactivity Disorder
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eicosanoids and Hypertension Pharmacology
- Ferroptosis and cancer prognosis
- Pancreatitis Pathology and Treatment
- Autophagy in Disease and Therapy
- Pancreatic and Hepatic Oncology Research
- Glaucoma and retinal disorders
- Colorectal Cancer Treatments and Studies
- Retinal Imaging and Analysis
- interferon and immune responses
- Otitis Media and Relapsing Polychondritis
- Metamaterials and Metasurfaces Applications
- Maternal Mental Health During Pregnancy and Postpartum
- Advanced Antenna and Metasurface Technologies
Shanxi Medical University
2022-2025
Peking University
2020-2025
Jilin University
2024-2025
Peking University Cancer Hospital
2020-2025
Shaanxi Provincial People's Hospital
2023-2025
Guangzhou Experimental Station
2024-2025
Guiyang Medical University
2022-2025
Affiliated Hospital of Guizhou Medical University
2025
Wenzhou Medical University
2022-2025
Ruian People's Hospital
2022-2025
Intra-pancreatic fat deposition (IPFD) is linked to metabolic and pancreatic diseases. MRI, while precise, not cost-effective for routine IPFD screening, highlighting the need accessible biomarkers. This study aims analyze relationships among serum lipid profiles, lipoprotein ratios, IPFD, with a focus on sex differences. Data from adults at Affiliated Hospital of Guizhou Medical University between 2018 2019 were analyzed. The subjects underwent Siemens 64-slice spiral CT scans, was...
Functional Assessment of Self-Mutilation (FASM) is one the most widely used tools assessing adolescent's non-suicidal self-injury. However, Chinese version FASM (C-FASM) lacking. The present study aimed to adapt patients and examine its reliability validity.The original English was translated into following Brislin's model cross-culture translation, then, pilot cognitive interview were carried out with 15 adolescent assess acceptability comprehensibility all items. items subsequently tested...
Immune checkpoint blockade (ICB) therapy has revolutionized the treatment of lung squamous cell carcinoma (LUSC). However, a significant proportion patients with high tumour PD-L1 expression remain resistant to immune inhibitors. To understand underlying resistance mechanisms, characterization immunosuppressive microenvironment and identification biomarkers predict in are urgently needed.Our study retrospectively analysed RNA sequencing data 624 LUSC samples. We gene patterns from by...
Abstract Background and Purpose Membranous nephropathy (MN) is an immune‐mediated glomerular disease in adults. Antibody‐ antigen‐bonding mechanisms have been largely clarified, but the subepithelium immune complex deposition‐mediated downstream molecular are currently unresolved. Increasing evidence has suggested that gut microbiota contribute to MN pathogenesis. Experimental Approach In this study, we identified alterations faecal serum metabolites mediate aryl hydrocarbon receptor (AhR)...
Abstract Accumulated evidence suggested that gut microbial dysbiosis interplayed with progressive chronic kidney disease (CKD). However, no available therapy is effective in suppressing CKD. Here, using microbiomics 480 participants including healthy controls and patients stage 1–5 CKD, we identified an elongation taxonomic chain Bacilli-Lactobacillales-Lactobacillaceae- Lactobacillus - johnsonii correlated CKD progression, whose abundance strongly clinical markers. L. reduced rats...
ABSTRACT Using five complementary short- and long-read sequencing technologies, we phased assembled >95% of each diploid human genome in a four-generation, 28-member family (CEPH 1463) allowing us to systematically assess de novo mutations (DNMs) recombination. From this family, estimate an average 192 DNMs per generation, including 75.5 single-nucleotide variants (SNVs), 7.4 non-tandem repeat indels, 79.6 indels or structural (SVs) originating from tandem repeats, 7.7 centromeric SVs...
Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival benefits. Our preclinical data showed the promising antitumor activity of afatinib EGFR-overexpressing ESCC. This proof-of-concept, phase II trial assessed efficacy and safety pretreated metastatic ESCC patients (n = 41) with EGFR overexpression (NCT03940976). The study met its primary endpoint, a confirmed objective...
Untargeted metabolomic analysis using mass spectrometry provides comprehensive metabolic profiling, but its medical application faces challenges of complex data processing, high inter-batch variability, and unidentified metabolites. Here, we present DeepMSProfiler, an explainable deep-learning-based method, enabling end-to-end on raw signals with output accuracy reliability. Using cross-hospital 859 human serum samples from lung adenocarcinoma, benign nodules, healthy individuals,...
Abstract Background This study aimed to investigate if the homocysteine-lowering efficacy of two commonly used physiological doses (0.4 mg/d and 0.8 mg/d) folic acid (FA) can be modified by individual methylenetetrahydrofolate reductase (MTHFR) C677T and/or methionine synthase (MTR) A2756G polymorphisms in hypertensive Chinese adults. Methods A total 480 subjects with mild or moderate essential hypertension were randomly assigned three treatment groups: 1) enalapril only (10 mg, control...
Natural few-layer graphene is unambiguously identified from the Chang'e-5 lunar soil samples, which serves as a new platform for investigating extraterrestrial bodies.
Arachidonic acid (AA) is a main component of cell membrane lipids. AA mainly metabolized by three enzymes: cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYP450). Esterified hydrolysed phospholipase A 2 into free form that further COX, LOX CYP450 to wide range bioactive mediators, including prostaglandins, lipoxins, thromboxanes, leukotrienes, hydroxyeicosatetraenoic acids epoxyeicosatrienoic acids. Increased mitochondrial oxidative stress considered be central mechanism in...