A5056302754- Treatment of Major Depression
- Tryptophan and brain disorders
- Suicide and Self-Harm Studies
- Neuropeptides and Animal Physiology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Diet and metabolism studies
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Restraint-Related Deaths
- Bipolar Disorder and Treatment
- Child Development and Digital Technology
- Health disparities and outcomes
- Homicide, Infanticide, and Child Abuse
- Educational Methods and Impacts
- EEG and Brain-Computer Interfaces
- Metabolomics and Mass Spectrometry Studies
- Mental Health Treatment and Access
- Migraine and Headache Studies
- Homelessness and Social Issues
- Substance Abuse Treatment and Outcomes
- Transcranial Magnetic Stimulation Studies
- Neurological and metabolic disorders
- Child and Adolescent Psychosocial and Emotional Development
- Alcohol Consumption and Health Effects
- Pain Management and Treatment
Soochow University
2019-2025
Suzhou Guangji Hospital
2019-2025
<title>Abstract</title> <bold>Objective</bold> Although the regulatory role of autonomic-cardiovascular interaction pathways in pathophysiology affective disorders has been extensively studied, their dynamic with suicide susceptibility anxiety-depression comorbidity remains mechanistically undefined. The present study specifically investigated nonlinear dose-response relationship between ambulatory blood pressure (BP) parameters - systolic (SBP) and diastolic (DBP)-and risk attempted...
The considerable clinical heterogeneity of schizophrenia poses significant challenges for elucidating its neurobiology. concept deficit (DS) is a valuable framework addressing the schizophrenia. Growing evidence suggests notable differences between and nondeficit (NDS) schizophrenia, indicating that DS could represent separate disease entity. We aimed to use FreeSurfer identify specific changes in cortical thickness among NDS patients healthy controls (HCs) Chinese sample. Furthermore, we...
Although antipsychotic medications are effective in managing schizophrenia (SCZ), there still no strategies or preventive measures to address the weight gain associated with long-term use of these medications. We performed a single-blind, randomized, sham-controlled clinical trial explore efficacy noninvasive high-frequency repetitive transcranial magnetic stimulation (rTMS) technology reducing body patients SCZ. Fifty-three obese chronic stable SCZ (BMI ≥30 kg/m2) completed 4-week...
There is an urgent need to identify differentiating and disease-monitoring biomarkers of schizophrenia, bipolar disorders (BD), major depressive (MDD) improve treatment management.We recruited 54 first-episode schizophrenia (FES) patients, 52 BD 35 MDD healthy controls from inpatient outpatient clinics. α-Melanocyte Stimulating Hormone (α-MSH), β-endorphin, neurotensin, orexin-A, oxytocin, substance P were investigated using quantitative multiplex assay method. Psychotic symptoms measured...
Abstract Human lipidome still remains largely unexplored among Chinese schizophrenia patients. We aimed to identify novel lipid molecules associated with and cognition The current study included 96 male patients gender-matched healthy controls. Untargeted lipidomics profiling was conducted all participants. Logistic regression models were used assess metabolite associations schizophrenia. further assessed the incremental predictive value of identified metabolites beyond conventional risk...
Depression (DP) and schizophrenia (SCZ) are both highly prevalent psychiatric disorders, their diagnosis depends on the examination of symptoms clinical tests, which can be subjective. As a measure real-time neural activity, Electroencephalographic (EEG) has shown its usability to classify people either as normal or having DP SCZ, but automatic classification between three categories (DP, SCZ normal) was rarely reported. Here, we propose an diagnostic framework based convolutional network...
Non-suicidal self-injury (NSSI) is a common feature among adolescents with mood disorders. Although childhood maltreatment has shown to be associated non-suicidal (NSSI), previous studies have yielded mixed results in terms of different subtypes and only few investigated the effects gender. The present cross-sectional study types on NSSI, as well role gender these effects.In this study, total 142 Chinese adolescent inpatients disorders (37 males 105 females) were consecutively recruited...
The aim of this research was to examine the association between alcohol consumption and depressive symptoms in Wa ethnic minority China, a population where relationship has been insufficiently explored.
Abstract Introduction Psychotic depression (PD) is characterized by the co-occurrence of emotional dysfunction and psychotic symptoms such as delusions hallucinations with poor clinical outcomes. TSH may involve in development PD. This study aims to explore relationship between Methods A total 1718 outpatients diagnosed FEDN MDD were recruited this study. The PD was evaluated using multivariable binary logistic regression analysis. To assess presence non-linear associations, a two-piecewise...
Objective The risk of suicide can be decreased by accurately identifying high-risk groups and implementing the right interventions. aim this study was to develop a nomogram for attempts (SA) in patients with first-episode drug-naïve (FEDN) major depressive disorder (MDD). Methods This undertook cross-sectional analysis 1,718 diagnosed FEDN MDD, providing comprehensive clinical data from September 2016 December 2018. Data on anthropometric sociodemographic factors were gathered, severity...
A cross-sectional study was conducted on the FEDN patients with MDD, and 1,718 patients' demography information clinical data were collected. The Hamilton Depression Scale (HAMD), Anxiety (HAMA), Positive Negative Syndrome (PANSS) used to evaluate symptoms of depression, anxiety, psychotic symptoms, respectively. Thyroid hormones, lipid profile, fasting blood glucose (FBG) measured. history suicide attempt verified based medical records interviews their families. 2 × ANOVA compare parameters...
Abstract Depression and obesity are both risk factors for suicide attempts; however, the pattern of attempts in individuals with major depressive disorder (MDD) who overweight or obese remains uncertain. The purpose this study was to examine prevalence variables first-episode drug-naïve (FEND) MDD patients obesity. This included a total 1026 FEDN were obese. Their demographic data metabolic parameters collected. To patients' symptoms, researchers employed Hamilton Scale (HAMD), Anxiety...
Abstract Background There is an urgent need to identify differentiating and disease-monitoring biomarkers of schizophrenia, bipolar disorders (BD), major depressive (MDD) improve treatment management. Methods We recruited 54 first-episode schizophrenia (FES) patients, 52 BD 35 MDD healthy controls from inpatient outpatient clinics. α-Melanocyte-Stimulating Hormone (α-MSH), β-endorphins, neurotensin, orexin-A, oxytocin, substance P were investigated using quantitative multiplex assay method....
Background: Comorbidity of mental disorders hampers diagnosis and treatment which leaves the heavier disease burden, but little is known about its prevalence contributing factors in China among general population. Method: Mental Health Survey (CMHS), a cross-sectional epidemiological face-to-face household survey, was organized by Peking University Sixth Hospital cooperation with 43 institutes across 31 provinces China, from July 2013 to March 2015. The trained lay interviewers conducted...
Abstract Background: Non-suicidal self-injury (NSSI) is a common feature among adolescents with mood disorders. Although childhood maltreatment has shown to be associated non-suicidal (NSSI), previous studies have yielded mixed results in terms of different subtypes and only few investigated the effects gender. The present cross-sectional study types on NSSI, as well role gender these effects. Methods: In this study, total 142 Chinese adolescent inpatients disorders (37 males 105 females)...