A5102840213- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Vitamin D Research Studies
- Thyroid Cancer Diagnosis and Treatment
- Health disparities and outcomes
- Intergenerational Family Dynamics and Caregiving
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Stress Responses and Cortisol
- Metabolism, Diabetes, and Cancer
- Thyroid Disorders and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Dialysis and Renal Disease Management
- Bipolar Disorder and Treatment
- Psychological Well-being and Life Satisfaction
- Functional Brain Connectivity Studies
- Aluminum toxicity and tolerance in plants and animals
- Rabies epidemiology and control
- Hedgehog Signaling Pathway Studies
- Biomedical Research and Pathophysiology
- Cardiovascular Function and Risk Factors
- Plant Toxicity and Pharmacological Properties
- 14-3-3 protein interactions
- Glycosylation and Glycoproteins Research
- Pancreatic function and diabetes
Baoshan College
2025
The Fourth People's Hospital
2021-2025
Nanjing Medical University
2021-2025
The First People’s Hospital of Lianyungang
2021-2025
Kangda College of Nanjing Medical University
2021-2025
Jiangsu Provincial Center for Disease Control and Prevention
2022-2024
Shanghai First People's Hospital
2020-2024
Shanghai Jiao Tong University
2020-2024
Huaibei Normal University
2023
Nanjing University of Chinese Medicine
2023
Depressive and anxiety symptoms are widespread among adolescents today, creating a large social problem. However, few previous studies have addressed depression in Chinese cohorts. The aim of this study was to evaluate the prevalence risk factors for depressive middle school adolescent students post-COVID-19 era.A total 22,380 from Jiangsu Province were surveyed online, their general demographic data collected. Patient Health Questionnaire-9 (PHQ-9) used assess symptoms, seven-item...
Abstract Background Accumulating evidence has indicated that oxidative stress (OS) and matrix metalloproteinase-9 (MMP-9) may contribute to the mechanism of schizophrenia. In present study, we aimed evaluate associations OS parameters MMP-9 levels with psychopathological symptoms in male chronic schizophrenia patients. Methods This study was an observational, cross-sectional, retrospective case-control study. Plasma hydrogen peroxide (H 2 O ), malondialdehyde (MDA), superoxide dismutase...
Elderly migrants who face the dual challenges of aging and migration are more likely to suffer psychological disorders. Existing research has demonstrated a link between loneliness disorders in general elderly population. However, we know little about relationships among migrants, mechanisms linking them. This study aims examine effects on anxiety depressive symptoms Chinese explore mediating roles perceived stress resilience. All 654 participants were recruited Nanjing, Jiangsu Province,...
Abstract Background Schizophrenia, a severe mental disorder with complex pathophysiology, involves neurotrophic factors, which play crucial roles in neurodevelopment and neuroplasticity. This study investigated NGF-β BDNF levels chronic schizophrenia their association clinical symptoms, cognitive function, 1,25(OH)₂D levels. Methods In this cross-sectional study, 72 male patients 70 matched healthy controls were enrolled. Psychopathological symptoms assessed using the Positive Negative...
Inflammation has an important role in the pathogenesis of schizophrenia. The aim this study was to investigate levels tumor necrosis factor (TNF) and matrix metalloproteinase-2 (MMP-2) male patients with treatment-resistant schizophrenia (TRS) chronic medicated (CMS), relationship psychopathology.
With the augmentation of family migration, number and proportion elderly migrants have increased dramatically in China. The well-being this group has a profound impact on whole society. Subjective is comprehensive reflection whether person’s needs are met. In cross-sectional study, we established multiple mediation model to evaluate mediating effects loneliness self-esteem intergenerational emotional support and, consequently, subjective migrants. study population consisted 728 living...
Context: Plants of the genus Cistanche Hoffmg. et Link (Orobanchaceae) are usually used as ethno-medicine in Eastern Asia. Pharmacology studies have shown that possesses an androgen-like effect; however, exact mechanism is unclear.Objective: The present study determines effect ethanol extract tubulosa (Schenk) R. Wight stem (CTE) on hormone levels and testicular steroidogenic enzymes rats.Materials methods: Phenylethanoid glycoside content CTE was detected by UV spectrophotometry. Rats were...
Oxidative stress (OS) and neuroinflammatory pathways play an important role in the pathophysiology of schizophrenia. The present study investigated relationship between OS, inflammatory cytokines, clinical features male patients with treatment-resistant schizophrenia (TRS).We measured plasma OS parameters, including manganese-superoxide dismutase (Mn-SOD), copper/zinc-containing SOD (CuZn-SOD), total-SOD (T-SOD), malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GSH-Px); serum...
The aim of this study was to generate a polygenic risk score (PRS) for type 2 diabetes (T2D) and test whether it could be used in identifying high-risk individuals lifestyle intervention Chinese cohort. We genotyped 80 genetic variants among 5024 participants without non-communicable diseases at baseline the Wuxi Non-Communicable Diseases cohort (Wuxi NCDs cohort). During follow-up period 14 years, 440 cases T2D were newly diagnosed. Using Cox regression, we found that PRS 46 SNPs identified...
Abstract Background Neuregulin1 (NRG1) plays a role in neuronal migration, regulation of synaptic plasticity, and neural survival, has been considered to be among the candidate genes for schizophrenia. This study focused on variations serum NRG1β1 levels following antipsychotic treatment relationship between improvements psychotic symptoms first-episode drug-naïve (FEDN) patients with chronic Methods A total 100 schizophrenia were recruited compared 79 matched healthy controls. All had at...
The present study aimed to examine whether plasma oxidative stress is associated with cognitive impairment in long term hospitalized patients chronic schizophrenia.Ninety-six schizophrenia and 94 healthy unaffected subjects were enrolled. Plasma markers of stress, including malondialdehyde (MDA), manganese superoxide dismutase (MnSOD), catalase (CAT), glutathione peroxidase (GSH-Px), measured. Psychiatric symptoms function assessed the Positive Negative Syndrome Scale (PANSS) Repeatable...
It is essential to improve the current predictive ability for type 2 diabetes (T2D) risk.We aimed identify novel metabolic markers future T2D in Chinese individuals of Han ethnicity and determine whether combined effect genetic improves accuracy prediction models containing clinical factors.A nested case-control study 220 incident patients age- sex- matched controls from normoglycemic was conducted within Wuxi Non-Communicable Disease cohort with a 12-year follow-up. Metabolic profiling...
Abstract Background Polypharmacy increases the risk of potential drug–drug interactions (pDDIs). This retrospective analysis was conducted to detect pDDIs and adverse drug reactions (ADRs) among older adults with psychiatric disorder, identify clinical significance. Methods A carried out based on medical records disorders. Data demographic characteristics, substance abuse, history, medications were extracted. The Lexi-Interact online database used pDDIs. minimal clinically important...
Abstract Background Polypharmacy is common in older adults with psychiatric disorders, but no consensus has reached about the reliable indicators evaluating benefits and risks of drug-drug interactions (DDIs) polypharmacy. We aimed to identify suitable for clinical significance DDIs polypharmacy disorders. Methods The online tools were used distribute collect questionnaires. Delphi method was applied analyze experts’ opinions. degree authority coordination experts analyzed using coefficient...
Abstract Background Subclinical hypothyroidism (SCH) is reportedly associated with an increased risk of adverse events in patients undergoing percutaneous coronary intervention (PCI). The prognostic significance SCH the elderly was poorly defined. purpose this study to evaluate association between and long-term outcomes older PCI. Methods Three thousand one hundred sixty-eight aged 65 years or who underwent PCI from January 2012 October 2014 were included. Patients divided into group ( n =...
To evaluate the value and feasibility of capillary glucose assessment, combined with other non-laboratory measures, in screening for diabetes prediabetes community.In this cross-sectional study, we assessed fasting glucose, plasma both values after 2-h oral tolerance tests a total 3736 samples. We determined optimal threshold using receiver-operating characteristic curve analysis. The effect methods variables, such as age, BMI waist circumference, was according to area under curve.There...
Pure red cell aplasia (PRCA) is a rare complication of erythropoietin (EPO) therapy, characterized by severe deficiency in blood production. There no guideline on the treatment for PRCA because there have been too few cases to perform prospective cohort studies. The main treatments include immediate cessation EPO, restrictive transfusion, and immunosuppressive therapies. A 35-year-old male patient with type 1 diabetic nephropathy was diagnosed PRCA. Enarodustat roxadustat were administered...
Abstract Background: Inflammation has an important role in the pathogenesis of schizophrenia. The aim this study was to investigate levels tumor necrosis factor (TNF) and matrix metalloproteinase-2 (MMP-2) male patients with treatment-resistant schizophrenia (TRS) chronic medicated (CMS), relationship psychopathology. Methods: enrolled 31 TRS 49 CMS patients, 53 healthy controls. Serum MMP-2 TNF-a were measured by Luminex liquid suspension chip detection method. Positive Negative Syndrome...