A5101693364- Genetic Associations and Epidemiology
- Folate and B Vitamins Research
- Nutrition, Genetics, and Disease
- Metabolomics and Mass Spectrometry Studies
- Lipid metabolism and disorders
- Ferroptosis and cancer prognosis
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Health disparities and outcomes
- Alzheimer's disease research and treatments
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Connexins and lens biology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related gene regulation
- Global Health Care Issues
- Trace Elements in Health
- Cancer-related Molecular Pathways
- Biliary and Gastrointestinal Fistulas
- Genomic variations and chromosomal abnormalities
- Glycosylation and Glycoproteins Research
- Gallbladder and Bile Duct Disorders
- Drug Transport and Resistance Mechanisms
Nanjing Medical University
2001-2024
Jiangsu Province Hospital
2010-2024
National Center for Chronic and Noncommunicable Disease Control and Prevention
2024
Jiangsu Provincial Center for Disease Control and Prevention
2014-2024
Shanghai Sixth People's Hospital
2024
Shanghai Jiao Tong University
2024
Shenzhen University
2020-2023
Nanjing Maternity and Child Health Care Hospital
2023
Second Affiliated Hospital of Zhejiang University
2020
State Key Laboratory of Reproductive Medicine
2016
Colorectal cancer (CRC) is a major cause of global mortality. Gene expression profiles can help predict prognosis patients with CRC. In most previous studies, disease recurrence was analyzed as the survival endpoint. Thus we aim to build robust gene signature for prediction overall (OS) in Fresh frozen CRC tissues from 64 were using Affymetrix HG-U133plus 2.0 arrays. By performing univariate analysis, 6487 genes found be associated OS our cohort. KEGG analysis revealed that these mainly...
Amino-containing compounds, including amino acids, aliphatic amines, aromatic small peptides and catecholamines, are involved in various biological processes play vital roles multiple metabolic pathways. Previous studies indicated that some amino-containing metabolites significant diagnostic prognostic biomarkers of gastric cancer. However, the discovery precise for preoperative diagnosis cancer is still an urgent need. Herein, we established a polarity-regulated derivatization method...
Observational studies suggest that moderate alcohol consumption may be protective for cardiovascular disease, but results biased by confounding and reverse causality. Mendelian randomization, which uses genetic variants as proxies exposures, can minimise these biases therefore strengthen causal inference. Using a variant in the ALDH2 gene associated with consumption, rs671, we performed randomization analysis 1,712 diabetes cases 2,076 controls from Nantong, China. Analyses were using linear...
A characteristic phenotype of congenital generalized lipodystrophy 2 (CGL2) that is caused by loss-of-function seipin gene mental retardation. Seipin highly expressed in hippocampal pyramidal cells and astrocytes. Neuronal knockout mice (seipin-KO mice) reduces the peroxisome proliferator-activated receptor gamma (PPARγ) level without loss cells. The down-regulation PPARγ has gained increasing attention neuroinflammation Alzheimer's disease (AD). Thus, present study focused on exploring...
Autoimmune encephalitis (AE) comprises a group of inflammatory brain disorders mediated by autoimmune responses. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, anti-leucine-rich glioma-inactivated 1 (LGI1) and anti-γ-aminobutyric acid-B (GABABR) are the most prevalent forms, characterized presence antibodies against neuronal cell-surface antigens. Efgartigimod, an antagonist neonatal Fc receptor, has proven efficacy in myasthenia gravis treatment. This clinical case report...
Different populations have diverse patterns of relationships between Impaired Fasting Glucose (IFG) and obesity lipid markers, it is important to investigate the characteristics associations IFG other related risk factors including body mass index (BMI), waist circumstance (WC), serum lipids blood pressure (BP) in a Chinese population. This was case-control study 648 subjects 1,296 controls derived from large-scale, community-based, cross-sectional survey 10,867 participants. Each subject...
Background Genome-wide association studies (GWAS) in populations of European ancestry have mapped a type 2 diabetes susceptibility region to chromosome 10q23.33 containing IDE, KIF11 and HHEX genes (IDE-KIF11-HHEX), which has also been replicated Chinese populations. However, the functional relevance for genetic variants at this locus is still unclear. It critical systematically assess relationship with risk diabetes. Methodology/Principal Findings A fine-mapping study was conducted by...
Objective To achieve the goal of "healthy China 2030", reasonable health policies must be developed based on changes death spectrum. We aim to investigate temporal patterns life expectancy (LE) and age/cause-specific contributions from 1990 2016. Methods Joinpoint regression model was used with Arriaga's decomposition method. Results LE in has reached 76.3 years 2016 an increase 9.44 1990. From 2002, a remarkable reduction infant mortality accounted for 1.27 (35.39%) which mainly resulted...
The aim of this study was to generate a polygenic risk score (PRS) for type 2 diabetes (T2D) and test whether it could be used in identifying high-risk individuals lifestyle intervention Chinese cohort. We genotyped 80 genetic variants among 5024 participants without non-communicable diseases at baseline the Wuxi Non-Communicable Diseases cohort (Wuxi NCDs cohort). During follow-up period 14 years, 440 cases T2D were newly diagnosed. Using Cox regression, we found that PRS 46 SNPs identified...
Background Genome-wide association studies (GWAS) have identified dozens of single nucleotide polymorphisms (SNPs) associated with type 2 diabetes risk. We previously confirmed the associations genetic variants in HHEX, CDKAL1, VEGFA and FTO Han Chinese. However, cumulative effect predictive value these GWAS SNPs on risk Chinese are largely unknown. Methodology/Principal Findings conducted a two-stage case-control study consisting 2,925 cases 3,281controls to examine 30 by Significant were...
Several genome-wide association studies have discovered novel loci at chromosome 12q24, which includes mevalonate kinase (MVK), methylmalonic aciduria (cobalamin deficiency) cbIB type (MMAB), and potassium channel tetramerization domain-containing 10 (KCTD10), all of influence HDL-cholesterol concentrations. However, there are few reports on the associations between these polymorphisms HDL-C concentrations in Chinese population. This study aimed to evaluate functional three genes (MVK, MMAB...
It is essential to improve the current predictive ability for type 2 diabetes (T2D) risk.We aimed identify novel metabolic markers future T2D in Chinese individuals of Han ethnicity and determine whether combined effect genetic improves accuracy prediction models containing clinical factors.A nested case-control study 220 incident patients age- sex- matched controls from normoglycemic was conducted within Wuxi Non-Communicable Disease cohort with a 12-year follow-up. Metabolic profiling...
Background Aldosterone synthase (CYP11B2) T-344C gene polymorphism was found to be correlated with atrial fibrillation (AF) risk. However, the results of individual studies remain conflicting. Objective and methods A meta-analysis including 2,758 subjects from six performed explore correlation between CYP11B2 polymorphisms AF. The pooled odds ratios (ORs) their corresponding 95% confidence intervals (95% CIs) were evaluated by fixed– or random–effects model. Results significant relationship...
Abstract The incidence of colorectal cancer (CRC) is rising worldwide. Here, we identified SCNN1B as an outlier down-regulated in CRC and it functions a tumor suppressor. mRNA protein expression were primary cells. In tissue microarray cohort ( N = 153), was independent prognostic factor for favorable outcomes CRC. Ectopic cell lines suppressed proliferation, induced apoptosis, cycle arrest, migration vitro. Xenograft models validated suppressive function vivo. Mechanistically, Gene Set...