A5074402502- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- IL-33, ST2, and ILC Pathways
- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Immune Response and Inflammation
- CAR-T cell therapy research
- Immune cells in cancer
- Asthma and respiratory diseases
- Hematopoietic Stem Cell Transplantation
- Periodontal Regeneration and Treatments
- Adenosine and Purinergic Signaling
- Atherosclerosis and Cardiovascular Diseases
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Oral and gingival health research
- Extracellular vesicles in disease
- Rheumatoid Arthritis Research and Therapies
- Bone Metabolism and Diseases
- Cell Adhesion Molecules Research
- Cytomegalovirus and herpesvirus research
Sun Yat-sen University
2015-2025
Guangdong Medical College
2023-2025
China Medical University
2013-2025
First Hospital of China Medical University
2017-2025
Hebei Medical University
2025
Second Hospital of Hebei Medical University
2025
Songjiang District Central Hospital
2023-2025
Shanghai Jiao Tong University
2023-2025
Stomatology Hospital
2025
Third Affiliated Hospital of Sun Yat-sen University
2014-2024
Abstract Thymus-derived, natural CD4+CD25+ regulatory T cells can educate peripheral CD4+CD25− to develop suppressive activity by poorly understood mechanisms. TGF-β has IL-2-dependent costimulatory effects on alloactivated naive, human CD4+ and induces them ex vivo become potent contact-dependent, cytokine-independent suppressor cells. In this study, we report that are the targets of IL-2 TGF-β. These do not divide, but, instead, greatly increase numbers CD25+ cells, in turn, induce other...
Abstract IL-2 and TGF-β both have important roles in the induction maintenance of immunologic tolerance, but whether these cytokines act separately or together to achieve this effect is poorly understood. Although others reported that can directly enhance forkhead box protein P3 (Foxp3) transcription factor expression by natural CD4+CD25+ regulatory T cells, study, we report role on generation peripheral CD4+ cells indirect. Ab neutralization studies experiments with IL-2-deficient mice...
Abstract Previously we reported that TGF-β has an important role in the generation and expansion of human “professional” CD4+CD25+ regulatory T cells periphery have a cytokine-independent mechanism action. In this study used low-dose staphylococcal enterotoxin to induce cell-dependent Ab production. We report induces activated CD4+CD25− become Th3 suppressor cells. While stimulating CD4+ with modestly increased expression CD25 intracellular CTLA-4 primary cultures, upon secondary stimulation...
Abstract TGF-β has pleiotropic effects on T cell differentiation that are determined by other cytokines in the local environment. Whereas IL-2 and induce naive cells to become forkhead/winged helix transcription factor (Foxp3) positive regulatory (iTregs), combination of IL-6 induces IL-17-producing (Th17). Moreover, can use produced thymus-derived natural (nTregs) convert them Th17 cells. In this study, we report a major difference between iTregs nTregs. Treatment with did not affect Foxp3...
T cells undergo metabolic rewiring to meet their bioenergetic, biosynthetic and redox demands following antigen stimulation. To fulfil these needs, effector must adapt fluctuations in environmental nutrient levels at sites of infection inflammation. Here, we show that can utilize inosine, as an alternative substrate, support cell growth function the absence glucose vitro. metabolize inosine into hypoxanthine phosphorylated ribose by purine nucleoside phosphorylase. We demonstrate subunit...
Significance Natural regulatory T cells (nTregs) play important roles in preventing autoimmune diseases, but they may be unstable the presence of inflammation. Here we report that all - trans RA (atRA) not rapamycin prevents human nTregs from converting to Th1/Th17 and sustains their suppressive function inflammatory environments. Adoptive transfer pretreated with atRA enhances effects on xenograft-vs. host diseases. Moreover, show suppresses IL-1 receptor upregulation, accelerates IL-6...
Autoimmune diseases are characterized by an imbalance between regulatory T cells and effector T-cell subsets, such as Th1 Th17 cells. Studies have confirmed that natural CD4+Foxp3+ Tregs were unstable dysfunctional in the presence of pro-inflammatory cytokines. In current study, human CD39hi CD39low sorted from vitro after 7 days expansion. The functions both Treg subsets investigated under inflammatory conditions vivo. IL-1β IL-6, cultured CD4+CD39hi maintained stable forkhead box protein 3...
Group 2 innate lymphoid cells (ILC2s) are recently reported to play a more critical role in allergic diseases. We previously identified that mesenchymal stromal (MSCs) elicited therapeutic effects on airway inflammation. Small extracellular vesicles (sEV) derived from MSCs possess striking advantages including low immunogenicity and high biosafety, is extremely promising cell-free agents. However, the of MSC-sEV ILC2s still unclear. Additionally, scalable isolation protocols required for...
Retinal ischemia-reperfusion injury (IRI) is one of the main pathogenic mechanisms glaucoma, which are largely unknown, including neuroinflammation and neuronal death in pathological process. In our previous studies, mesenchymal stem cells (MSCs) have been reported to play anti-inflammatory neuroprotective roles. Additionally, conditioned culture medium (CM) MSCs stimulated by TNF-α achieved better antiallergic effects an experimental allergic conjunctivitis mouse model. However, there...
Abstract Mortality rates due to lung cancer are high worldwide. Although PD‐1 and PD‐L1 immune checkpoint inhibitors boost the survival of patients with non‐small‐cell (NSCLC), resistance often arises. The Warburg Effect, which causes lactate build‐up potential lysine‐lactylation (Kla), links dysfunction tumor metabolism. role non‐histone Kla in microenvironment immunotherapy remains be clarified. Here, global lactylome profiling metabolomic analyses samples from NSCLC is conducted. By...
Abstract Although positive CD28 costimulation is needed for the generation of natural CD4+CD25+ regulatory T cells, we report that negative CTLA-4 necessary generating phenotypically and functionally similar adaptive suppressor cells. TGF-β could not induce CD4+CD25− cells from CTLA-4−/− mice to express normal levels FoxP3 or develop activity. Moreover, blockade following activation wild-type CD4+ abolished ability FoxP3-expressing mouse accelerated expression CTLA-4, time course studies...
Abstract Regulatory T cells generated ex vivo from conventional mouse have been used to prevent and alter the course of a stimulatory graft-vs-host disease with lupus-like syndrome. DBA/2 induce this syndrome when injected into (DBA/2 × C57BL/6) F1 mice. Stimulating irradiated C57BL/6 in presence IL-2 TGF-β induced both CD4+ CD8+ develop potent suppressive activity enhanced their survival. The TGF-β-treated lost ability and, instead, prevented other parental inducing lymphoid hyperplasia, B...
Recent studies have demonstrated that plasticity of naturally occurring CD4(+)Foxp3(+) regulatory T cells (nTregs) may account for their inability to control chronic inflammation in established autoimmune diseases. All-trans retinoic acid (atRA), the active derivative vitamin A, has been promote Foxp3(+) Treg differentiation and suppress Th17 development. In this study, we report a vital role atRA sustaining stability functionality nTregs presence IL-6. We found treated with were resistant...
Abstract Objective Current approaches offer no cures for rheumatoid arthritis (RA). Accumulating evidence has revealed that manipulation of bone marrow–derived mesenchymal stem cells (BM‐MSCs) may have the potential to control or even prevent RA, but BM‐MSC–based therapy faces many challenges, such as limited cell availability and reduced clinical feasibility. This study in mice with established collagen‐induced (CIA) was undertaken determine whether substitution human gingiva‐derived...