A5013645258- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Glaucoma and retinal disorders
- Retinopathy of Prematurity Studies
- Ferroptosis and cancer prognosis
- Retinal Development and Disorders
- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Congenital Anomalies and Fetal Surgery
- Single-cell and spatial transcriptomics
- Acute Ischemic Stroke Management
- Neuroscience and Neuropharmacology Research
- Cardiovascular Health and Disease Prevention
- Customer Service Quality and Loyalty
- Ophthalmology and Visual Impairment Studies
- Frailty in Older Adults
- MicroRNA in disease regulation
- Geotechnical Engineering and Underground Structures
- Pancreatitis Pathology and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Consumer Behavior in Brand Consumption and Identification
- Cultural Differences and Values
- Seismic Performance and Analysis
Sun Yat-sen University
2021-2025
Key Laboratory of Guangdong Province
2023
Jinan University
2021
Jiangxi University of Technology
2021
Retinal ischemia-reperfusion injury (IRI) is one of the main pathogenic mechanisms glaucoma, which are largely unknown, including neuroinflammation and neuronal death in pathological process. In our previous studies, mesenchymal stem cells (MSCs) have been reported to play anti-inflammatory neuroprotective roles. Additionally, conditioned culture medium (CM) MSCs stimulated by TNF-α achieved better antiallergic effects an experimental allergic conjunctivitis mouse model. However, there...
Increased cellular senescence burden contributes in part to age-related organ dysfunction and pathologies. In our study, using mouse models of natural aging, we observed structural functional decline the aged retina, which was accompanied by accumulation senescent cells senescence-associated secretory phenotype factors. We further validated senolytic senomorphic properties procyanidin C1 (PCC1) both vitro vivo, long-term treatment ameliorated retinal impairment. Through high-throughput...
Abstract Background The aim of this study was to establish a complete retinal cell atlas ischemia–reperfusion injury by single-cell RNA sequencing, and explore the underlying mechanism in mice. Methods Single-cell sequencing used evaluate changes mouse ischemia reperfusion model. In vivo vitro experiments were performed verify protective effect inhibiting ferroptosis injury. Results After injury, cells significantly reduced, accompanied activation myeloid large amount blood-derived immune...
To elucidate the relationship between diabetic retinopathy (DR) and frailty investigate genetic correlations causality. We analyzed data from US National Health Nutrition Examination Survey, which included 1003 individuals with diabetes. DR was evaluated via nonmydriatic retinal imaging, measured using a 49-item index. The association assessed survey-weighted logistics regression adjusted for multiple covariates, including age, sex, race, education level, family income-to-poverty ratio,...
Previous studies on the Structural Alignment Model suggest that people compare alignable attributes and nonalignable during decision-making process preference formation process. Alignable are easier to more effective in clue extracting. Thus, it is believed rely than when comparing alternatives. This article supposes consumers’ product experience personal characteristics also play a significant role regulating reliance attribute alignability. The authors conducted three experiments examine...
Despite the significant impact of blindness on affected individuals' quality life, its burden has not been assessed according to temporal cause-specific changes in severity, impeding our ability evaluate population health accurately. Therefore, we aimed comprehensively quantify disease severity for 18 causes blindness.
In order to consider the effect of near-field vertical earthquake, a model two-span continuous beam bridge is established. On basis superposition longitudinal and seismic actions, possible separation earthquake considered, influence on structural failure calculated. The transient wave characteristic function method indirect mode are used solve response theory structure during earthquake. When excitation period close natural vibration bridge, may separate. For high-pier-type enlarges...
Age-related macular degeneration is the leading cause of irreversible visual impairment in elderly. It manifests two forms, wet and dry. However, mechanisms underlying spontaneous dry age-related (SD-AMD) remain unclear. Herein, we constructed a single-cell retinal transcription atlas aged non-human primates with SD-AMD. Retinal tissues affected by SD-AMD exhibited more degenerative dysfunctional transcriptomic landscape, global activation oxidative stress response apoptotic signaling...
Retinitis pigmentosa (RP), characterized by the gradual loss of rod and cone photoreceptors that eventually leads to blindness, is most common inherited retinal disorder, affecting more than 2.5 million people worldwide. However, underlying pathogenesis RP remains unclear there no effective cure for RP. Mutations in Mer receptor tyrosine kinase (MERTK) gene induce phagocytic dysfunction pigment epithelium (RPE) cells, leading Studies have indicated filamentous actin (F-actin)-which regulated...
<title>Abstract</title> Retinitis pigmentosa (RP) is the most common inherited blinding retinal degenerative disease characterized by progressive loss of photoreceptors and pigment epithelium (RPE) that eventually causes degeneration. However, mechanisms initiate RP drive vulnerability remain incompletely understood, new strategies for its prevention therapy are urgently needed. Mitochondrial dysfunction initiator a variety neurodegeneration, whether mitochondrial an important pathogenic...