A5087988582- Immune Cell Function and Interaction
- Hippo pathway signaling and YAP/TAZ
- T-cell and B-cell Immunology
- Peptidase Inhibition and Analysis
- Adenosine and Purinergic Signaling
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Research and Treatments
- Immune cells in cancer
- NF-κB Signaling Pathways
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Genomics, phytochemicals, and oxidative stress
- Advanced Glycation End Products research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Artificial Immune Systems Applications
- Cytokine Signaling Pathways and Interactions
- Hematopoietic Stem Cell Transplantation
- Erythrocyte Function and Pathophysiology
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Galectins and Cancer Biology
The First Affiliated Hospital, Sun Yat-sen University
2023
Sun Yat-sen University
2022-2023
Nanjing Medical University
2015-2020
Jiangsu Province Hospital
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Sidney Kimmel Comprehensive Cancer Center
2016-2018
Johns Hopkins University
2016-2018
Bloomberg (United States)
2016-2018
National Health and Family Planning Commission
2018
Johns Hopkins Medicine
2018
Significance Cytotoxic chemotherapy is frequently used in patients with triple-negative breast cancer (TNBC). Although initially respond to the treatment, often comes back and kills patient. Recent studies have demonstrated that cells express genes protect them from killing by immune cells, but stimulus prompts this response unknown. We show when TNBC are treated chemotherapy, surviving turn on enable escape system. identify hypoxia-inducible factors (HIFs), which known promote metastasis of...
Abstract Regulatory T cells (Treg) are critical for maintaining self-tolerance and immune homeostasis, but their suppressive function can impede effective antitumor responses. FOXP3 is a transcription factor expressed in Tregs that required function. However, the pathways microenvironmental cues governing expression Treg not completely understood. Herein, we report YAP, coactivator of Hippo pathway, highly bolsters vitro vivo. This potentiation stemmed from YAP-dependent upregulation activin...
Autoimmune diseases are characterized by an imbalance between regulatory T cells and effector T-cell subsets, such as Th1 Th17 cells. Studies have confirmed that natural CD4+Foxp3+ Tregs were unstable dysfunctional in the presence of pro-inflammatory cytokines. In current study, human CD39hi CD39low sorted from vitro after 7 days expansion. The functions both Treg subsets investigated under inflammatory conditions vivo. IL-1β IL-6, cultured CD4+CD39hi maintained stable forkhead box protein 3...
Abstract Activating transcription factor 3 (ATF3) is a stress-induced that plays important roles in regulating immune and metabolic homeostasis. Activation of the mechanistic target rapamycin (mTOR) hypoxia-inducible (HIF) factors are crucial for regulation cell function. Here, we investigated mechanism by which ATF3/mTOR/HIF-1 axis regulates responses liver ischemia/reperfusion injury (IRI) model. Deletion ATF3 exacerbated damage, as evidenced increased levels serum ALT, intrahepatic...
Cancer-associated fibroblasts (CAFs) are a major component of hepatocellular carcinoma (HCC) stroma that critically involved in HCC cancer chemoresistance, but the mechanism has not been elucidated. Previous studies have reported CD73 exerted an immunosuppressive function cancer. Here, we explored by which CAFs regulates CD73+ cells and clarified whether promote chemoresistance cells.We used co-culture method to study relationship between cells. Immunohistochemistry was applied evaluate...
Abstract In the past few decades, advances in outcomes of patients suffering from pancreatic ductal adenocarcinoma (PDAC) have lagged behind these gained treatment many other malignancies. Although pivotal role SUMO pathway PDAC has been illustrated, underlying molecule drivers yet to be fully elucidated. present study, we identified SENP3 as a potential suppressor progression through an vivo metastatic model. Further studies revealed that inhibited invasion system dependent fashion....
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has third highest mortality rate among all cancers. MicroRNAs are a class endogenous, single-stranded short noncoding RNAs. The purpose this study was to role microRNA-873 in HCC.The expression miRNA-873 tumor suppressor lung 1 (TSLC1) HCC tissues cell lines detected by real-time quantitative RT-PCR (RT-qPCR) or western blot. A CCK-8 assay used examine proliferation; flow cytometry assess cycle; Transwell...
Abstract Human gingival tissue-derived mesenchymal stem cells (GMSCs) present an accessible source of (MSCs) for treating autoimmune diseases. Here we show that human GMSCs can prevent and treat acute graft-versus-host disease (GVHD) in two different mouse models. Our results indicate besides exhibiting suppressive function vitro vivo, may also regulate the conversion Tregs to Th1 and/or Th17-like cells, as well stabilize Foxp3 expression. Furthermore, GMSC-mediated prevention GVHD was...
Ginsenoside Rg1, one of the most notable active components Panax ginseng, has been widely reported to exert anti-inflammatory actions. This study aimed reveal whether ginsenoside Rg1 also exhibits beneficial roles against lipopolysaccharide (LPS)-induced apoptosis and inflammation in human renal tubular epithelial cells, evaluate potential role component on tubulointerstitial nephritis treatment. HK-2 cells were treated with various doses (0, 50, 100, 150, 200 μM) absence or presence 5 μg/mL...
<div>Abstract<p>Regulatory T cells (Treg) are critical for maintaining self-tolerance and immune homeostasis, but their suppressive function can impede effective antitumor responses. FOXP3 is a transcription factor expressed in Tregs that required function. However, the pathways microenvironmental cues governing expression Treg not completely understood. Herein, we report YAP, coactivator of Hippo pathway, highly bolsters <i>in vitro</i> vivo.</i> This...
<div>Abstract<p>Regulatory T cells (Treg) are critical for maintaining self-tolerance and immune homeostasis, but their suppressive function can impede effective antitumor responses. FOXP3 is a transcription factor expressed in Tregs that required function. However, the pathways microenvironmental cues governing expression Treg not completely understood. Herein, we report YAP, coactivator of Hippo pathway, highly bolsters <i>in vitro</i> vivo.</i> This...
<p>Supplementary Figure S1. Expression and activation of YAP other Hippo Pathway factors in CD4+ T cell subsets; Supplementary S2. Characterization the baseline immune profile cell-specific YAP-deficient mice; S3. Haematoxylin eosin staining lung, kidney, liver, small intestine stomach sections from 21-day-old wild-type YAPcKO S4. The effect on iTreg generation under optimal TGFβ concentration; S5. Treg-specific deficiency slows growth implanted MC38-colon tumors boosts anti-tumor...
<p>Supplementary Figure S1. Expression and activation of YAP other Hippo Pathway factors in CD4+ T cell subsets; Supplementary S2. Characterization the baseline immune profile cell-specific YAP-deficient mice; S3. Haematoxylin eosin staining lung, kidney, liver, small intestine stomach sections from 21-day-old wild-type YAPcKO S4. The effect on iTreg generation under optimal TGFβ concentration; S5. Treg-specific deficiency slows growth implanted MC38-colon tumors boosts anti-tumor...