A5100690561- Cancer Research and Treatments
- Escherichia coli research studies
- Gut microbiota and health
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Phytochemistry and Biological Activities
- RNA Research and Splicing
- Antibiotic Resistance in Bacteria
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Genetics, Bioinformatics, and Biomedical Research
- Ubiquitin and proteasome pathways
- Cytokine Signaling Pathways and Interactions
- Colorectal Cancer Screening and Detection
- Inflammatory mediators and NSAID effects
- Digestive system and related health
- MicroRNA in disease regulation
- Bioactive natural compounds
- Hippo pathway signaling and YAP/TAZ
Nanjing Forestry University
2024
Harvard University
2020-2023
Shandong Maternal and Child Health Hospital
2023
Shandong University
2023
Beth Israel Deaconess Medical Center
2020-2023
Chinese University of Hong Kong
2016-2022
Institute of Microbiology
2022
Chinese Academy of Sciences
2022
Jiangsu Province Hospital
2021
Wenzhou Medical University
2018-2020
Background & AimsMutant KRAS promotes glutaminolysis, a process that uses steps from the tricarboxylic cycle to convert glutamine α-ketoglutarate and other molecules via glutaminase SLC25A22. This results in inhibition of demethylases epigenetic alterations cells increase proliferation stem cell features. We investigated whether mutant KRAS-mediated glutaminolysis affects epigenomes activities colorectal cancer (CRC) cells.MethodsWe created ApcminKrasG12D mice with intestine-specific...
Metabolic dysfunction is a hallmark of gastric cancer (GC). In this study, we reported the identification Calcium Binding Protein 39-Like (CAB39L) as novel regulator tumor metabolism in GC. CAB39L mRNA was frequently silenced by promoter methylation GC cell lines and tissues. Functional studies suggested that functions suppressor, overexpression elicited suppression multiple phenotypes both cells an orthotopic mouse model; whilst its knockdown promoted tumorigenesis. Mechanistically,...
There remains a paucity of functional biomarkers in gastric cancer. Here, we report the identification sodium channel subunit SCNN1B as candidate biomarker mRNA expression was silenced commonly by promoter hypermethylation cancer cell lines and primary tumor tissues. Tissue microarray analysis revealed that high an independent prognostic factor for longer survival patients, especially those with late-stage disease. Functional studies demonstrated overexpression sufficient to suppress...
Promoter methylation plays a vital role in tumorigenesis through transcriptional silencing of tumor suppressive genes. Using genome-wide array, we first identified PBX/Knotted Homeobox 2 (PKNOX2) as candidate suppressor gastric cancer. PKNOX2 mRNA expression is largely silenced cancer cell lines and primary via promoter methylation. was associated with poor survival patients. A series vitro vivo functional studies revealed that functions suppressor. Ectopic inhibited proliferation GC...
Abstract Peritoneal metastasis is a common form of among advanced gastric cancer patients. In this study, we reported the identification LIM domain kinase 1 (LIMK1) as promoter peritoneal metastasis, and its potential to be therapeutic target dabrafenib (DAB). Using transcriptomic sequencing paired primary tumors, normal tissues, first unveiled that LIMK1 selectively up-regulated in metastatic tumors. Increased was validated by immunohistochemistry analysis an independent patient cohort....
Slit-Robo GTPase-activating protein 1 (SRGAP1) functions as a GAP for Rho-family GTPases and downstream of signaling. We aim to investigate the biological function SRGAP1 reveal its regulation by deregulated microRNAs (miRNAs) in gastric cancer (GC). mRNA expression were examined quantitative reverse transcription PCR (qRT-PCR) western blot. The role was demonstrated through siRNA-mediated knockdown experiments. miR-340 miR-124 confirmed blot, dual luciferase activity assays rescue is...
Bladder cancer (BC) is the most common malignant disease. The developing of economically sustainable and available agents for treatment BC required. Purple sweet potato anthocyanin (PSPA) has been shown to have antitumor abilities. present study aimed evaluate potential role PSPA in treatment. CCK-8 assay was used assess viability cells. Flow cytometry assays were performed mitochondrial membrane (MMP), cell apoptosis cell-cycle distribution. Real-time PCR (RT-PCR) western blot analysis...
A fast and novel sample preparation procedure: ultrasound assisted ionic liquid (IL) dispersive extraction for the concentration of lovastatin simvastatin in aqueous samples was developed. An IL ([C(6)MIM][PF(6)]) used as solvent, factors affecting efficiency such initial temperature, volume IL, pH water samples, cooling time, salt were optimized. In combination with HPLC-UV, both exhibited a good linear range 1-100 ng/mL. The limits detection (LODs) 0.17 0.29 ng/mL, respectively. Precisions...
Rationale: Prostaglandin E2 (PGE2) is a pro-inflammatory eicosanoid up-regulated in gastric cancer (GC).However, its impact on epigenetic dysfunction the process of carcinogenesis unknown.In this study, we investigate role PGE2 DNA methylation epithelium vitro, mice, and humans.Methods: PGE2-induced DNMT3B was determined cell lines COX-2 transgenic mice.Effect inhibition evaluated randomized controlled trial.Efficacy combined COX-2/PGE2 DNMT GC growth examined mice models.Results: PCR array...
Abstract Bacterial infection is linked to colorectal carcinogenesis, but the species that contribute a protumorigenic ecology are ill-defined. Here we report evidence α-hemolysin–positive (hly+) type I Escherichia coli (E. coli) drives adenomagenesis and cancer in human females not males. We classified E. into four types using novel typing method monitor fimH mutation patterns of fecal isolates from adenoma patients (n= 59), 83), healthy subjects 85). hly+ was found be relatively more...
Abstract The incidence of colorectal cancer (CRC) is rising worldwide. Here, we identified SCNN1B as an outlier down-regulated in CRC and it functions a tumor suppressor. mRNA protein expression were primary cells. In tissue microarray cohort ( N = 153), was independent prognostic factor for favorable outcomes CRC. Ectopic cell lines suppressed proliferation, induced apoptosis, cycle arrest, migration vitro. Xenograft models validated suppressive function vivo. Mechanistically, Gene Set...
Premature ovarian insufficiency (POI) is a heterogeneous disease affecting the physical and mental health of millions women worldwide. The contribution genetic factors in pathogenesis POI has increased, with quite few causative genes involved meiosis. ZMM proteins are group conserved participating meiotic synapsis crossover maturation. Here, by screening variations our in-house WES database 1030 idiopathic patients, one novel homozygous variation SPO16 (c.160 + 8A > G) was firstly identified...
Cervical carcinoma high-expressed long non-coding RNA (lncRNA) 1 (lncRNA-CCHE1) serves an oncogenic role in cervical and liver cancer. The present study aimed to explore the of CCHE1 pancreatic adenocarcinoma. expression was detected by reverse transcription-quantitative polymerase chain reaction, rho associated coiled-coil containing protein kinase (ROCK1) levels were using ELISA assay. Diagnostic analysis performed receiver operating characteristic curve analysis. effects on ROCK1 analyzed...
Abstract RNF6 is a RING finger protein with oncogenic potential. In this study, we established colon-specific transgenic (tg) mice, and demonstrated that overexpression accelerated colorectal carcinogenesis compared to wild-type littermates in chemically induced cancer (CRC) model. To understand whether transcriptional activity of underlies its effect, performed integrated chromatin immunoprecipitation (ChIP)-sequencing RNA-sequencing analysis identify splicing factor 3b subunit 2 (SF3B2) as...
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