A5101424119- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Colorectal Cancer Screening and Detection
- RNA modifications and cancer
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Cancer-related gene regulation
- Microscopic Colitis
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- Animal Genetics and Reproduction
- Muscle Physiology and Disorders
- Diet and metabolism studies
- Galectins and Cancer Biology
- Trace Elements in Health
- Esophageal Cancer Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Metastasis and carcinoma case studies
- Cancer Cells and Metastasis
- Iron Metabolism and Disorders
Sir Run Run Shaw Hospital
2013-2024
Zhejiang University
2015-2024
Zhejiang Cancer Hospital
2021-2022
Sichuan Agricultural University
2009-2012
Mount Elizabeth Hospital
2008
Shiga University of Medical Science
2008
Second Affiliated Hospital of Zhejiang University
2006
The enrichment of Fusobacterium nucleatum (Fn) has been identified in CRC patients and associated with worse outcomes. However, whether Fn was involved the metastasis not well determined. Here, we found that abundance significantly increased lymph nodes metastasis. To further clarify role metastasis, performed transwell wound healing assays after incubating cell lines or without injected Fn-treated untreated cells into nude mice via tail vein. results indicated infection promoted migration...
The gut microbiota and host immune response interaction influences the progression of intestinal inflammatory disease. As a well-recognized next-generation probiotic, Akkermansia muciniphila has been proved to play crucial role in colitis, but its underlying mechanism remains inconclusive.
Inflammatory bowel disease (IBD) is defined as an immune dysregulation with poor prognosis. Various therapies based on gut microbe modulation have been proposed. In this study, we aim to explore the therapeutic effect of B. adolescentis IBD, well and microecology mechanism in IBD. The fecal level was decreased IBD patients compared normal people our cohort GMrepo database. To further clarify role induced chronic colitis three cycles dextran sulfate sodium (DSS). We found gavage exhibited...
Metastasis is the leading cause of death for colorectal cancer (CRC) patients, and spreading tumor cells adhesion to endothelial a critical step extravasation further distant metastasis. Previous studies have documented important roles gut microbiota-host interactions in CRC malignancy, Fusobacterium nucleatum (F. nucleatum) was reported increase proliferation invasive activities cells. However, potential functions underlying mechanisms F. between subsequent remain unclear. Here, we...
The interplay between gut microbiota and the host immune system is emerging as a factor in pathogenesis of colorectal cancer. Here, we set out to identify effect Akkermansia muciniphila (A. muciniphila) on cancer pathogenesis. A. abundance was significantly reduced patients with from two independent clinical cohorts GMrepo dataset. Supplementation suppressed colonic tumorigenesis ApcMin/+ mice growth implanted HCT116 or CT26 tumors nude mice. Mechanistically, facilitated enrichment M1-like...
Type 2 resistant starch (RS2) is a fermentable dietary fiber conferring health benefits. We investigated the effects of RS2 on host, gut microbiota, and metabolites in aged mice high-fat diet. In eighteen-month old randomly assigned to control, (HF), or high-fat+20% (HFRS) diet for 16 weeks, reversed weight gain hepatic steatosis induced by Serum fecal LPS, colonic IL-2 IL-4 mRNA expressions decreased while mucin protein increased HFRS compared HF control group. 16s rRNA sequencing microbial...
Abstract Background The interplay between gut microbiota and tumor microenvironment (TME) in the pathogenesis of colorectal cancer (CRC) is not well explored. Here, we elucidated functional role Bifidobacterium adolescentis ( B.a ) on CRC investigated its possible mechanism manipulation cancer‐associated fibroblasts (CAFs) CRC. Methods Different animal models various cell line were established to explore function single‐cell RNA sequencing (scRNA‐seq) or flow cytometry was used detect...
Abstract Aging‐induced cognitive impairment is associated with a loss of metabolic homeostasis and plasticity. An emerging idea that targeting key metabolites sufficient to impact the function other organisms. Therefore, more metabolism‐targeted therapeutic intervention needed improve impairment. We first conducted untargeted metabolomic analyses 16S rRNA identify aging‐associated adaption intestinal microbiome change. Untargeted plasma revealed L‐arginine was altered during aging process....
Abstract Pyogenic liver abscess (PLA) is a common intra-abdominal infection in adults. In this study, we aim to explore demographic and clinical characteristics of PLA focusing on Klebsiella pneumoniae (K. ) induced (KP-PLA) mainland China. A retrospective review medical records from all patients with KP-PLA admitted tertiary teaching hospital over 21-year period (1994–2015) was performed. Among 296 cases confirmed culture-positive data, K. revealed as the predominant pathogen ( n = 189,...
Irritable bowel syndrome (IBS) is at high risk of co-morbid depression and anxiety, which reduces patients' quality life increases the burden health care costs. However, pathophysiological mechanisms responsible for IBS still remain unknown. This study investigated effects resveratrol on stress-related depression, intestinal visceral dysfunction in rat model IBS. Rats received chronic acute combining stress (CACS) procedures 22 days exhibited depression/anxiety-like behavior,...
Recently, there has been an increase in the incidence of malignant tumors among older population. Moreover, is association between aging and cancer. During process senescence, human body suffers from a series imbalances, which have shown to further accelerate aging, trigger tumorigenesis, facilitate cancer progression. Therefore, exploring junctions searching for novel methods restore great importance intervene against aging-related cancers. In this review, we identified underlying...
Gut microbiome is integral to the pathogenesis of ulcerative colitis. A novel probiotic Lactobacillus intestinalis (L. intestinalis) exerts a protective effect against dextran sodium sulfate-induced colitis in mice. Based on flow cytometry, colitis-associated Th17 cells are target L. intestinalis, which supported by lack effects T cell-null Rag1
Declined numbers and weakened functions of intestinal stem cells (ISCs) impair the integrity epithelium during aging. However, impact microbiota on ISCs in this process is unclear. Here, using premature aging mice (telomerase RNA component knockout, Terc-/-), natural mice, vitro colonoid models, we explore how heat-inactivated Bifidobacterium adolescentis (B. adolescentis) affects colon senescence. We find that B. could mitigate colonic senescence-related changes by enhancing stimulating...
Homeobox D10 (HoxD10) gene plays a critical role in cell differentiation and morphogenesis during development. However, the function of HoxD10 tumor progression remains largely unknown. We demonstrate that expression is commonly downregulated gastric cancer tissues (n = 33) lines 8) relative to normal stomach tissues. Functionally, reexpression results significant inhibition survival, induction apoptosis, impairment migration invasion. Moreover, ectopic suppresses growth mouse xenograft...
Abstract The paired box 5 ( PAX5 ) is a member of PAX transcription factors family involved in the regulation embryonic development. However, role carcinogenesis largely unclear. We identified that human cancer by methylation-sensitive representational difference analysis. examined biological functions and related molecular mechanisms hepatocellular carcinoma (HCC). Promoter methylation was evaluated methylation-specific polymerase chain reaction (PCR) bisulfite genomic sequencing (BGS)....
There remains a paucity of functional biomarkers in gastric cancer. Here, we report the identification sodium channel subunit SCNN1B as candidate biomarker mRNA expression was silenced commonly by promoter hypermethylation cancer cell lines and primary tumor tissues. Tissue microarray analysis revealed that high an independent prognostic factor for longer survival patients, especially those with late-stage disease. Functional studies demonstrated overexpression sufficient to suppress...
The transcription factor, Zinc finger of the cerebellum (ZIC1), plays a crucial role in vertebrate development. Recently, ZIC1 has also been found to participate progression human cancers, including medulloblastomas, endometrial and mesenchymal neoplasms. However, function colon cancer not defined. In this study, we demonstrate be silenced or significantly downregulated cell lines. These effects were reversed by demethylation treatment with 5-aza-2′-deoxycytidine (Aza). expression is primary...