A5100692584- Genetic Mapping and Diversity in Plants and Animals
- High Altitude and Hypoxia
- Adipose Tissue and Metabolism
- Soybean genetics and cultivation
- Genetic and phenotypic traits in livestock
- Genetics and Plant Breeding
- Neuroscience of respiration and sleep
- Human Mobility and Location-Based Analysis
- Wheat and Barley Genetics and Pathology
- Rice Cultivation and Yield Improvement
- Legume Nitrogen Fixing Symbiosis
- Physiological and biochemical adaptations
- Genetic Associations and Epidemiology
- Energy, Environment, Economic Growth
- Urban Transport and Accessibility
- Environmental Impact and Sustainability
- Traffic Prediction and Management Techniques
- Lipid metabolism and biosynthesis
- Air Quality Monitoring and Forecasting
- Catalytic Processes in Materials Science
- Migration, Aging, and Tourism Studies
- Diverse Topics in Contemporary Research
- Plant pathogens and resistance mechanisms
- Ammonia Synthesis and Nitrogen Reduction
- Cancer, Hypoxia, and Metabolism
Zhejiang Provincial People's Hospital
2025
Hangzhou Medical College
2021-2025
Hainan University
2024
Peking University
2024
Beijing University of Chinese Medicine
2024
Jiangsu University
2024
Chinese National Human Genome Center at Shanghai
2024
Huazhong Agricultural University
2018-2023
Huanggang Normal University
2023
Sir Run Run Shaw Hospital
2023
Previous studies have reported that some important loci are missed in single-locus genome-wide association (GWAS), especially because of the large phenotypic error field experiments. To solve this issue, multi-locus GWAS methods been recommended. However, only a few software packages for available. Therefore, we developed an R named mrMLM v4.0.2. This integrates mrMLM, FASTmrMLM, FASTmrEMMA, pLARmEB, pKWmEB, and ISIS EM-BLASSO by our lab. There four components v4.0.2, including dataset...
Tibetan chicken, unlike their lowland counterparts, exhibit specific adaptations to high-altitude conditions. The genetic mechanisms of such in highland chickens were determined by resequencing the genomes four (Tibetan and Lhasa White) (White Leghorn, Lindian, Chahua) chicken populations. Our results showed an evident admixture chickens, suggesting a history introgression from gene pools. Genes showing positive selection populations related cardiovascular respiratory system development, DNA...
Declined numbers and weakened functions of intestinal stem cells (ISCs) impair the integrity epithelium during aging. However, impact microbiota on ISCs in this process is unclear. Here, using premature aging mice (telomerase RNA component knockout, Terc-/-), natural mice, vitro colonoid models, we explore how heat-inactivated Bifidobacterium adolescentis (B. adolescentis) affects colon senescence. We find that B. could mitigate colonic senescence-related changes by enhancing stimulating...
In the genetic system that regulates complex traits, metabolites, gene expression levels, RNA editing levels and DNA methylation, a series of small linked genes exist. To date, however, little is known about how to design an efficient framework for detection these kinds genes. this article, we propose genome-wide composite interval mapping (GCIM) in F2. First, controlling polygenic background via selecting markers genome scanning linkage analysis was replaced by estimating variance...
Abstract Seed oil traits in soybean that are of benefit to human nutrition and health have been selected for during crop domestication. However, these domesticated significant differences across various evolutionary types. In this study, we found the integration population structure (evolutionary types) with genome-wide association studies increased power gene detection, it identified one locus related seed size content on chromosome 13. This domestication locus, together another a 200-kb...
Pandoraea apista is notable for its multidrug resistance and frequently identified in patients with cystic fibrosis or other chronic lung diseases, where it contributes to persistent infections. In this study, we describe a strain of P. harboring the blaOXA-153, isolated from bronchoalveolar lavage (BAL) fluid an inpatient China. The genomic DNA PA167 was sequenced using Illumina NovaSeq 6000 system assembled SPAdes v.3.13.0. Antimicrobial genes (ARGs) were ResFinder v.3.2 within ABRicate...
Understanding the genetic function of forage quality-related traits, including crude protein (CP), neutral detergent fiber (NDF), acid (ADF), hemicellulose (HC), and cellulose (CL) contents, is essential for identification quality genes selection effective molecular markers in sorghum. In this study, we genotyped 245 sorghum accessions by 85,585 single-nucleotide polymorphisms (SNPs) obtained phenotypic data from four environments. The SNPs were applied to multi-locus genome-wide association...
Accurate next-day air quality prediction is essential to enable warning and prevention measures for cities individuals cope with potential pollution, such as vehicle restriction, factory shutdown, limiting outdoor activities. The problem challenging because affected by a diverse set of complex factors. There has been prior work on short-term (e.g., next 6 hours) prediction, however, there limited research modeling local weather influences or fusing heterogeneous data prediction. This paper...
Although the biochemical and genetic basis of lipid metabolism is clear in Arabidopsis, there limited information concerning relevant genes Glycine max (soybean). To address this issue, we constructed three-dimensional networks using six seed oil-related traits, 52 metabolism-related metabolites 54 294 SNPs 286 soybean accessions total. As a result, 284 279 candidate were found to be significantly associated with traits by phenotypic metabolic genome-wide association studies multi-omics...
Highlights•Although QTL mapping methods are well established, it is difficult to detect small and linked QTLs.•An R software QTL.gCIMapping.GUI v2.0 has been developed identify QTLs.•This program can be used all kinds of omics QTLs.AbstractThe methodologies packages for quantitative trait loci (QTLs) in bi-parental segregation populations established. However, still small-effect QTLs. To address this issue, we proposed a genome-wide composite interval (GCIM) populations. popularize method,...
Tibetan pigs, which inhabit the Plateau, exhibit distinct phenotypic and physiological characteristics from those of lowland pigs have adapted well to extreme conditions at high altitude. However, genetic epigenetic mechanisms hypoxic adaptation in animals remain unclear. Whole-genome DNA methylation data were generated for heart tissues grown highland (TH, n = 4) (TL, 4), as Yorkshire (YH, (YL, using methylated immunoprecipitation sequencing. We obtained 480 million reads detected 280679,...
Abstract The Tibetan chicken is a unique breed that has adapted to the high-altitude hypoxic conditions of plateau. A number positively selected genes have been reported in these chickens; however, mechanisms gene expression for hypoxia adaptation are not fully understood. In present study, eggs from and Chahua chickens were incubated under normoxic conditions, vascularization chorioallantoic membrane (CAM) embryos was observed. We found vessel density index CAM lower than conditions....
100-seed weight (100-SW) in soybeans is a yield component trait and controlled by multiple genes with different effects, but limited information available for its quantitative nucleotides (QTNs) candidate genes. To better understand the genetic architecture underlying improve precision of marker-assisted selection, total 43,834 single nucleotide polymorphisms (SNPs) 250 soybean accessions were used to identify significant QTNs 100-SW four environments their BLUP values using six multi-locus...
Although grain size is an important quantitative trait affecting rice yield and quality, there are few studies on gene-by-environment interactions (GEIs) in genome-wide association studies, especially, main crop (MC) ratoon (RR). To address these issues, the phenotypes for width (GW), length (GL), thousand weight (TGW) of 159 accessions MC RR two environments were used to associate with 2,017,495 SNPs detecting nucleotides (QTNs) QTN-by-environment (QEIs) using 3VmrMLM. As a result, 64, 71,...
Abstract As a well‐established topic, single‐atom catalyst has drawn growing interest for its high utilization of metal. However, researchers prefer to develop various active metals with form, the intrinsic roles promoters are usually underrated, which significant in boosting reaction activity. In this work, Ba single atoms were situ prepared Co−Ba/Y 2 O 3 crystallized BaCO as precursor under ammonia decomposition condition. The optimized achieves extremely H production rate 138.3 mmolH ⋅ g...
Liver fibrosis is a major global health concern. Management of chronic liver disease severely restricted in clinics due to ineffective treatment approaches. However, lack targeted therapy may aggravate this condition. Asiatic acid (AA), pentacyclic triterpenoid acid, can effectively protect the from hepatic disorders. pharmaceutical application AA limited by low oral bioavailability and poor targeting efficiency. This study synthesized novel liver-targeting material PEG-SA, chemically linked...
Objective: To prepare everolimus nanoformulations and increase their solubility to suit application in the eye. Methods: The micelles was prepared by thin film dispersion method using Tween-80 (P80) polyoxyethylene stearate (P40S) as carriers. In addition, nanosuspension injection poloxamer 407 (P407), hydroxypropyl methylcellulose (HPMC) polyvinyl alcohol (PVA) stabilizers. It characterized terms of particle size, PDI encapsulation efficiency or drug loading. vitro release rabbit scleral...
Theoretical and applied studies demonstrate the difficulty of detecting extremely over-dominant small-effect genes for quantitative traits via bulked segregant analysis (BSA) in an F
Islet autoantibodies occur in type 2 diabetes. Our study aimed to investigate the prevalence of positive islet autoimmunity community patients with diabetes.A total 495 diabetes were recruited using method cluster sampling this cross-sectional study. Three including glutamic acid decarboxylase antibody (GADA), insulin autoantibody (IAA) and cell (ICA) measured, clinical characteristics involved those individuals evaluated.The rate was 28.5% total, while combinations different rarely seen....
Owing to high power and accuracy low false positive rate in our multi-locus approaches for genome-wide association studies linkage analyses, these have attracted considerable attention plant animal genetics. In large mapping population, however, fast random-SNP-effect efficient mixed model (FASTmrEMMA) composite interval (GCIM) run a relatively long time. To address this issue, we proposed the improved FASTmrEMMA GCIM algorithms study. new algorithms, some matrix identities, such as Woodbury...