A5101630721- Viral Infections and Immunology Research
- Advanced Photocatalysis Techniques
- Immunotherapy and Immune Responses
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Lysosomal Storage Disorders Research
- Immune Cell Function and Interaction
- Biochemical Acid Research Studies
- Alcoholism and Thiamine Deficiency
- Viral-associated cancers and disorders
- Viral gastroenteritis research and epidemiology
- MXene and MAX Phase Materials
- Cancer Mechanisms and Therapy
- SARS-CoV-2 and COVID-19 Research
- Glycogen Storage Diseases and Myoclonus
- Copper-based nanomaterials and applications
- Renal Diseases and Glomerulopathies
- Pressure Ulcer Prevention and Management
- Morphological variations and asymmetry
- Child Nutrition and Feeding Issues
- Viral Infections and Outbreaks Research
- Lymphoma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- RNA and protein synthesis mechanisms
- TiO2 Photocatalysis and Solar Cells
First Affiliated Hospital of Henan University
2025
Bengbu Medical College
2024
Institute of Biophysics
2015-2024
Chinese Academy of Sciences
2015-2024
Czech Academy of Sciences, Institute of Biophysics
2024
University of Science and Technology Beijing
2022
China Agricultural University
2020
University of Chinese Academy of Sciences
2015-2017
Jilin University
2014
DMG Mori (Japan)
2011
Hand, foot and mouth disease (HFMD) is a common pediatric illness mainly caused by infection with enterovirus 71 (EV71) coxsackievirus A16 (CA16). The frequent HFMD outbreaks have become serious public health problem. Currently, no vaccine or antiviral drug for EV71/CA16 infections has been approved. In this study, two-step screening platform consisting of reporter virus-based assays cell viability‑based was developed to identify potential inhibitors infection. Two types viruses, pseudovirus...
Scavenger receptor class B, member 2 (SCARB2) is linked to Gaucher disease and Parkinson's disease. Deficiency in the SCARB2 gene causes progressive myoclonus epilepsy (PME), a rare group of inherited neurodegenerative diseases characterized by myoclonus. We found that Scarb2 deficiency mice leads age-dependent dietary lipid malabsorption, accompanied with vitamin E deficiency. Our investigation revealed associated gut dysbiosis an altered bile acid pool, leading hyperactivation FXR...
Ebolavirus can cause hemorrhagic fever in humans with a mortality rate of 50%–90%. Currently, no approved vaccines and antiviral therapies are available. Human TIM1 is considered as an attachment factor for EBOV, enhancing viral infection through interaction PS located on the envelope. However, reasons underlying preferable usage hTIM-1, but not other binding receptors by filovirus, remain unknown. We firstly demonstrated direct between hTIM-1 EBOV GP vitro determined crystal structures Ig V...
Virus infection induces the production of type I interferons (IFNs). IFNs bind to their heterodimeric receptors initiate downstream cascade signaling, leading up-regulation interferon-stimulated genes (ISGs). ISGs play very important roles in innate immunity through a variety mechanisms. Although hundreds have been identified, it is commonly recognized that more await be discovered. The aim this study was identify new and probe regulating virus-induced IFN production. We used consensus...
Abstract The Tibetan chicken is a unique breed that has adapted to the high-altitude hypoxic conditions of plateau. A number positively selected genes have been reported in these chickens; however, mechanisms gene expression for hypoxia adaptation are not fully understood. In present study, eggs from and Chahua chickens were incubated under normoxic conditions, vascularization chorioallantoic membrane (CAM) embryos was observed. We found vessel density index CAM lower than conditions....
Interferons (IFNs) and the products of interferon-stimulated genes (ISGs) play crucial roles in host defense against virus infections. Although many ISGs have been characterized with respect to their antiviral activity, target specificities mechanisms action remain largely unknown. Kaposi’s sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that linked several human malignancies. Here, we used genetically biologically related virus, murine 68 (MHV-68) screened for...
Scavenger receptor class B, member 2 (SCARB2) is essential for endosome biogenesis and reorganization serves as a both β-glucocerebrosidase enterovirus 71. However, little known about its function in innate immune cells. In this study, we show that, among human peripheral blood cells, SCARB2 most highly expressed plasmacytoid dendritic cells (pDCs), expression further upregulated by CpG oligodeoxynucleotide stimulation. Knockdown of pDC cell line GEN2.2 dramatically reduces CpG-induced type...
Entero virus 71 (EV71) causes hand, foot, and mouth disease (HFMD) occasionally leads to severe neurological complications even death.Scavenger receptor class B member 2 (SCARB2) is a functional for EV71, that mediates viral attachment, internalization, uncoating.However, the exact binding site of EV71 on SCARB2 unknown.In this study, we generated monoclonal antibody (mAb) binds human but not mouse SCARB2.It named JL2, it can effectively inhibit infection target cells.Using set chimeras...
Deficiency in scavenger receptor class B, member 2 (SCARB2) is related to both Gaucher disease (GD) and Parkinson's (PD), which are neurodegenerative-related diseases without cure. Although lead weight loss, affects the quality of life progress diseases, underlying molecular mechanism still unclear. In this study, we found that Scarb2-/- mice showed significantly reduced lipid storage white fat tissues (WAT) compared WT on a regular chow diet. However, phenotype independent heat production,...
Abstract Dendritic cells (DCs) are sentinels of the immune system and comprise two distinct subsets: conventional DCs (cDCs) plasmacytoid (pDCs). Human pDCs distinguished from mouse phenotypically functionally. Basic helix-loop-helix protein E2-2 is defined as an essential transcription factor for pDC development, cell fate maintenance gene programe. It unknown whether regulation contributes to this species-specific difference. Here we investigated function in human screened human-specific...
Estimating the reliability and lifetime distribution of wireless sensor network is very useful in various applications. This problem known to be NP-hard. In this paper, we present a hexagon tessellation model with role assignment scheme estimate by employing new improved Monte Carlo which incorporates both simulation analytic methods suitable for WSN. The results show that node density have important effects on analyzing probability different situation.
To realize the automatic sorting of eggs, models are established in this paper by using visible-near infrared spectroscopy technique and taking eggshell colour, integrity, as well feeding mode indexes. A variety methods selected to remove noise systematic error preprocess spectral information. The backpropagation neural network (BP), Principal Component Analysis (PCA) coupled with BP Soft Independent Modeling Class Analogy (SIMCA) method used identify colours (white, pink, green), integrity...
Enterovirus 71 (EV71) is a significant causative agent of hand, foot, and mouth disease, with potential serious neurologic complications or fatal outcomes. The lack effective treatments for EV71 infection attributed to its elusive pathogenicity. Our study reveals that human plasmacytoid dendritic cells (pDCs), the main type I IFN-producing cells, selectively express scavenger receptor class B, member 2 (SCARB2) P-selectin glycoprotein ligand 1 (PSGL-1), crucial cellular receptors EV71. Some...
The use of sunlight for photocatalytic oxidation is an ideal strategy, but it limited by factors such as insufficient light absorption intensity the photocatalyst and easy recombination photogenerated electron holes. TiO 2 favored researchers environment-friendly catalyst. In this paper, combined with WO 3 to obtain a nanofiber excellent catalytic performance under sunlight. /TiO composite nanofibers were synthesized using electrospinning method. X-ray diffraction (XRD) analysis indicated...
WS 2 , as a potential cocatalyst to enhance the activation of H * is usually used for evolution. However, activity W atoms in sandwich structure blocked by surface S atoms. An situ F‐induced W‐exposure method developed boost W‐site (W exp ‐WS). ‐WS anchored on porous g‐C 3 N 4 and then ‐WS/g‐C photocatalyst with efficient obtained. Particularly, W‐exposed ensures coordination number decreases from 5.92 5.15 ‐WS, which improves ability results an optimized Δ G H* (−0.08 kJ mol −1 )....
Thiamine and pyridoxine are essential B vitamins that serve as enzymatic cofactors in energy metabolism, protein nucleic acid biosynthesis, neurotransmitter production. In humans, thiamine transporters SLC19A2 SLC19A3 primarily regulate cellular uptake of both vitamins. Genetic mutations these transporters, which cause deficiency, have been implicated severe neurometabolic diseases. Additionally, various prescribed medicines, including metformin fedratinib, manipulate complicating the...
<title>Abstract</title> Thiamine and pyridoxine are essential B vitamins that serve as enzymatic cofactors in energy metabolism, protein nucleic acid biosynthesis, neurotransmitter production. In humans, thiamine transporters SLC19A2 SLC19A3 primarily regulate cellular uptake of both vitamins. Genetic mutations these transporters, which cause deficiency, have been implicated severe neurometabolic diseases. Additionally, various prescribed medicines, including metformin fedratinib, manipulate...
<title>Abstract</title> Background and Objective: Adrenal incidentalomas (AIs) are predominantly adrenal adenomas (80%), with a smaller proportion (7%) being pheochromocytomas(PHEO). Adenomas typically non-functional tumors managed through observation or medication, some cases requiring surgical removal, which is generally safe. In contrast, PHEO secrete catecholamines, causing severe blood pressure fluctuations, making resection the only treatment option. Without adequate preoperative...
Abstract Problem Draining lymph nodes (LNs) are pivotal sites for maintaining tolerance to self‐antigens as well eliciting immune responses exogenous antigens. The epididymis is a male reproductive organ with unique local environment. Although mice the most commonly used laboratory animals immunology research, there no detailed descriptions of anatomical location and function LNs that drain epididymis. Method study Evans blue labeling was utilized explore lymphatic drainage in eight‐...