A5101660826- interferon and immune responses
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- Respiratory viral infections research
- HIV Research and Treatment
- Transition Metal Oxide Nanomaterials
- Ubiquitin and proteasome pathways
- Supercapacitor Materials and Fabrication
- RNA regulation and disease
- Electrocatalysts for Energy Conversion
- Virology and Viral Diseases
- Advanced battery technologies research
- Viral Infections and Vectors
- Protein Degradation and Inhibitors
- Electrochemical Analysis and Applications
- Advancements in Battery Materials
- Immune cells in cancer
- Toxin Mechanisms and Immunotoxins
- Hepatitis B Virus Studies
- Mosquito-borne diseases and control
- Herpesvirus Infections and Treatments
- RNA modifications and cancer
University of Chinese Academy of Sciences
2011-2025
Institute of Biophysics
2022-2025
Chinese Academy of Sciences
2011-2025
First Hospital of Jilin University
2014-2024
Jilin University
2014-2024
Southwest Petroleum University
2022-2024
Institute of Virology of the Slovak Academy of Sciences
2020-2024
Fujian Academy of Agricultural Sciences
2023
Wuhan University of Technology
2012-2018
Delft University of Technology
2018
CD4 + regulatory T (T reg ) cells accumulate in the tumor microenvironment (TME) and suppress immune system. Whether how metabolite availability TME influences cell differentiation is not understood. Here, we measured 630 metabolites found that serine palmitic acid, substrates required for synthesis of sphingolipids, were enriched. A serine-free diet or a deficiency Sptlc2, rate-limiting enzyme catalyzing sphingolipid synthesis, suppressed accumulation inhibited growth. Sphinganine, an...
Abstract SAMHD 1 possesses multiple functions, but whether cellular factors regulate expression or its function remains not well characterized. Here, by investigating why cultured RD and HEK 293T cells show different sensitivity to enterovirus 71 (EV71) infection, we demonstrate that is a restriction factor for EV71. Importantly, identify TRIM 21, an E3 ubiquitin ligase, as key regulator of 1, which specifically interacts degrades through the proteasomal pathway. However, 21 has no effect on...
Coronavirus disease 2019 (COVID-19) is a current global health threat caused by SARS-CoV-2. The innate immune response such as type I IFN (IFN-I) the first line of host defense against viral infections, whereas SARS-CoV-2 proteins antagonize IFN-I production through distinct mechanisms.
Guanylate binding protein 5 (GBP5) belongs to the GTPase subfamily, which is mainly induced by interferon gamma (IFN-γ) and involved in many important cellular processes, including inflammasome activation innate immunity against a wide variety of microbial pathogens. However, it unknown whether GBP5 inhibits respiratory syncytial virus (RSV) infection. In this study, we identified as an effector anti-RSV activity IFN-γ found that children, weaker immune response, especially response...
The solute carrier protein SLC19A1 is crucial for transporting folate nutrients, antifolate chemotherapeutics, and more recently cyclic dinucleotides (CDNs) immune transmitters, influencing various physiological pathological processes. While the inward-open state of human (hSLC19A1) has been previously described, key aspects regarding its conformational dynamics, substrate selectivity, precise mechanisms underlying CDNs transport remain elusive. Using an antibody-facilitated conformation...
Although human respiratory syncytial virus (RSV) is one of the most common viruses inducing tract infections in young children and elderly, genotype distribution characteristics RSV northeastern China have not been investigated. Here, we identified 25 RSV‐A 8 RSV‐B strains from 80 samples patients with between February 2015 May 2015. All were classified as ON1 genotype, which rapidly spread became dominant world since being Ontario (Canada) December 2010. eight belonged to BA a 60‐nucleotide...
Abstract Defense-associated sirtuin 2 (DSR2) systems are widely distributed across prokaryotic genomes, providing robust protection against phage infection. DSR2 recognizes tail tube proteins and induces abortive infection by depleting intracellular NAD + , a process that is counteracted another phage-encoded protein, DSR Anti Defense 1 (DSAD1). Here, we present cryo-EM structures of Bacillus subtilis in its apo, Tube-bound, DSAD1-bound states. assembles into an elongated tetramer, with four...
Human immunodeficiency virus type 1 (HIV-1) and simian (SIV) viral infectivity factor (Vif) form a CRL5 E3 ubiquitin ligase complex to suppress restriction by host APOBEC3 (A3) proteins. The primate lentiviral Vif is composed of the unique cofactor core binding β (CBF-β) canonical components Cullin 5 (CUL5), Elongin B/C (ELOB/C), RBX2. However, mechanism which protein related lentivirus bovine (BIV) overcomes its A3 proteins less clear. In this study, we show that BIV interacts with 2...
The lentiviral accessory proteins Vpx and Vpr are known to utilize CRL4 (DCAF1) E3 ligase induce the degradation of host restriction factor SAMHD1 or helicase transcription (HLTF), respectively. Selective disruption viral could be a promising antiviral strategy. Recently, we have determined that posttranslational modification (neddylation) Cullin-4 is required for activation Vpx-CRL4 ligase. However, mechanism Vpx/Vpr-CRL4 assembly still poorly understood. Here, report zinc coordination an...
SARS-CoV-2 belongs to the subgenus
The vanadium pentoxide (V2O5)/graphene nanocomposite films have been synthesized by direct intercalation method using V2O5 sol and graphene. structure of the was investigated with X-Ray Diffraction (XRD). electrochemical properties films were studied cyclic voltammetry chronoamperometry standard three-electrode configuration. optical characterized UV–Visible spectrophotometer. graphene improves stability reversibility xerogel films. response rate V2O5/graphene is enhanced. modulatory range...
Human enterovirus 68 (EVD68) is a primary causative agent for respiratory illness worldwide. Until now, there has been no available medication treating EVD68-related diseases. Rheum emodin, artemisinin, astragaloside, pseudolaric acid B, oridonin, and erianin are natural extracts from Chinese herbs that have traditionally used the treatment prevention of epidemic Our results showed B protected cells EVD68-induced cytopathic effects decreased viral production. However, same were not observed...
The intestinal microbiota and fecal metabolome have been shown to play a vital role in human health, can be affected by genetic environmental factors. We found that individuals with Down syndrome (DS) had abnormal serum cytokine levels indicative of pro-inflammatory environment. investigated whether these also alterations the microbiome. High-throughput sequencing bacterial 16S rRNA gene samples from 17 DS 23 non-DS volunteers revealed significantly higher abundance Prevotella,...
Abstract Increasing evidence indicates ATP1B3, one of the regulatory subunits Na + /K ‐ATPase, is involved in numerous viral propagations, such as HIV and EV71. However, function mechanism ATP1B3 on hepatitis B virus (HBV) propagation unknown. Here, we demonstrated that overexpression reduced quantity surface antigen (HBsAg) e (HBeAg) supernatants HBV expression plasmids cotransfected HepG2 cells. Correspondingly, small interfering RNA short hairpin mediated silencing promoted HBsAg HBeAg...
Caprine arthritis encephalitis virus (CAEV) is a lentivirus that causes multisystemic chronic disorders in sheep and goats. It encodes Vif to counteract the restriction of Ovis aries A3Z2-Z3 (oaA3Z2-Z3) by inducing their degradation. Nevertheless, mechanisms underlying interplay between CAEV OaA3Z2-Z3 have yet be elucidated. Here, we identified cellular factors ElonginB/C, CYPA Cullin5 as being hijacked well several functional domains required for degrading oaA3Z2-Z3. Moreover, determined...