A5100398495- Pesticide Exposure and Toxicity
- Mitochondrial Function and Pathology
- Cholinesterase and Neurodegenerative Diseases
- Cardiac Ischemia and Reperfusion
- Cancer-related molecular mechanisms research
- Ion channel regulation and function
- Retinoids in leukemia and cellular processes
- Heme Oxygenase-1 and Carbon Monoxide
- Carcinogens and Genotoxicity Assessment
- Eicosanoids and Hypertension Pharmacology
- Neuroscience and Neuropharmacology Research
- DNA Repair Mechanisms
- Immune Response and Inflammation
- RNA Research and Splicing
- Coenzyme Q10 studies and effects
- Enzyme Production and Characterization
- Microbial Natural Products and Biosynthesis
- Pesticide and Herbicide Environmental Studies
- ATP Synthase and ATPases Research
- Metabolomics and Mass Spectrometry Studies
- Cell death mechanisms and regulation
- Vitamin C and Antioxidants Research
- Pain Mechanisms and Treatments
- Trace Elements in Health
- Amino Acid Enzymes and Metabolism
Jiangsu Provincial Academy of Environmental Science
2025
Zhejiang University
2025
Army Medical University
2013-2024
Academy of Military Medical Sciences
2023
Institute of Microbiology
2023
Zhongda Hospital Southeast University
2023
Beijing Institute of Technology
2023
Wenzhou Medical University
2023
Huashan Hospital
2022
Fudan University
2022
<title>Abstract</title> <italic>RAD18</italic> is a crucial mismatch repair gene associated with the post-replication repair, and genetic variations in are closely related to tumorigenesis. We selected six SNP performed amplification PCR on 650 cases of CIN III, 580 CSCC, 1,320 healthy controls. The RAD18 rs250403 GG G-allele (AG + GG) genotype risk CINIII CSCC were significantly increased. results showed significant correlation between rs615967 III CSCC. Carriers at also had an increased...
In order to understand the molecular mechanisms of multidrug resistance (MDR) in ovarian cancer, we employed proteomic approach isobaric tags for relative and absolute quantification (iTRAQ), followed by LC-MS/MS, using cisplatin-resistant COC1/DDP cell line its parental COC1 as a model. A total number 28 proteins differentially expressed were identified, then differential expression levels partially identified confirmed Western blot analysis and/or real-time RT-PCR. Furthermore, association...
The voltage-gated calcium channel Ca(v)2.2 (N-type channel) is a critical regulator of synaptic transmission and has emerged as an attractive target for the treatment chronic pain. We report here discovery sulfonamide-derived, state-dependent inhibitors Ca(v)2.2. In particular, 19 inhibitor that selective over cardiac ion channels, with good preclinical PK biodistribution profile. This compound exhibits dose-dependent efficacy in models inflammatory hyperalgesia neuropathic allodynia devoid...
We report the investigation of sulfonamide-derived Cav2.2 inhibitors to address drug-metabolism liabilities with this lead class analgesics. Modification benzamide substituent provided improvements in both potency and selectivity. However, we discovered that formation persistent 3-(trifluoromethyl)benzenesulfonamide metabolite was an endemic problem sulfonamide series replacement center aminopiperidine scaffold failed prevent metabolic pathway. This issue eventually addressed by application...
The eicosanoid metabolic pathway is responsible for mediating the production of various inflammatory factors that are closely related to development and resolution inflammation. In biological matrices, major quantifying obstacles were shown be oxidation low quantities eicosanoids their metabolites. This study aimed develop a reliable, sensitive ultrahigh-performance liquid chromatography coupled tandem mass spectrometry (UPLC-MS/MS) method quantify in human serum. Solid-phase extraction...
Proansamycin X, a hypothetical earliest macrocyclic precursor in the biosynthesis of rifamycin, had never been isolated and identified. According to bioinformatics analysis, it was proposed that RifT (a putative NADH-dependent dehydrogenase) may be candidate target responsible for dehydrogenation proansamycin X. In this study, mutant strain Amycolatopsis mediterranei S699 ΔrifT constructed by deleting rifT gene. From strain, eleven 8-deoxy-rifamycin derivatives (1-11) seven known analogues...