A5046089814- Heme Oxygenase-1 and Carbon Monoxide
- Pesticide Exposure and Toxicity
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Retinoids in leukemia and cellular processes
- Vitamin C and Antioxidants Research
- Extracellular vesicles in disease
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammasome and immune disorders
- Immune cells in cancer
- Frailty in Older Adults
- Occupational Health and Performance
- Nutritional Studies and Diet
- Parkinson's Disease Mechanisms and Treatments
- Air Quality and Health Impacts
- Gut microbiota and health
- Carcinogens and Genotoxicity Assessment
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Sirtuins and Resveratrol in Medicine
- Genomics, phytochemicals, and oxidative stress
- Trace Elements in Health
- Disaster Response and Management
- Inflammation biomarkers and pathways
- Respiratory Support and Mechanisms
Army Medical University
2019-2024
State Council of the People's Republic of China
2019
Abstract Nitrogen mustard (NM) causes severe skin injury with an obvious inflammatory response, which is lack of effective and targeted therapies. Vitamin D3 (VD3) has excellent anti‐inflammatory properties considered as a potential candidate for the treatment NM‐induced dermal toxicity; however, underlying mechanisms are currently unclear. Cyclooxygenase‐2 (COX2; widely used marker inflammation) plays key role in cutaneous inflammation. Herein, we initially confirmed that NM markedly...
Ultrasound-triggered microbubble destruction (UTMD) is a widely used noninvasive technology in both military and civilian medicine, which could enhance radiosensitivity of various tumors. However, little information available regarding the effects UTMD on radiotherapy for glioblastoma or underlying mechanism. This study aimed to delineate effect potential involvement autophagy.GL261, U251 cells orthotopic glioblastoma-bearing mice were treated with ionizing radiation (IR) IR plus UTMD....
Abstract Nitrogen mustard (NM) causes severe vesicating skin injury, which lacks effective targeted therapies. The major limitation is that the specific mechanism of NM-induced injury not well understood. Recently, autophagy has been found to play important roles in physical and chemical exposure-caused cutaneous injuries. However, whether contributes dermal toxicity unclear. Herein, we initially confirmed NM dose-dependently caused cell death induced keratinocytes. Suppression by...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-caused disease 2019 (COVID-19) is a global crisis with no satisfactory therapies. Vitamin D3 (VD3) considered potential candidate for COVID-19 treatment; however, little information available regarding the exact effects of VD3 on SARS-CoV-2 infection and underlying mechanism. Herein, we confirmed that reduced nucleocapsid (N) protein-caused hyperinflammation in human bronchial epithelial (HBE) cells. Meanwhile, inhibited...
Abstract Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) still present a huge threaten to women’s health, especially the local advanced patients. Hence, developing more effectiveness prognostic signatures is urgently needed. This study constructed verified robust RNA-binding proteins (RBPs) related signature through series of bioinformatics methods explored biological function hub RBP in vitro experiments. As result, 10 RBPs was successfully established could act as...
1. Ruvuna L, Sood A. Epidemiology of chronic obstructive pulmonary disease. Clin Chest Med. 2020;41(3):315-327. doi:10.1016/j.ccm.2020.05.002 CrossRef Google Scholar
Nitrogen mustard (NM) is a chemotherapeutic agent capable of alkylating nucleophilic proteins and DNA, causing severe cell damage. However, no reports have been on the dynamic changes in proteomics induced by NM. In this study, we established model acute exposure to NM for 1 h continuous cultured 24 after removal (repair stage) using 16HBE cells. The nuclear protein spectrum crosslinked with DNA were analyzed, function p97 during damage was examined. An hour resulted into nucleus, which...
Abstract Nitrogen mustard (NM) belongs to vesicant agents. Blisters are one of the important characteristics NM skin damage. It is urgent further elucidate mechanism and develop effective countermeasures for damage induced by NM. The endoplasmic reticulum (ER) an intracellular organelle, playing role in maintaining cellular homeostasis. In this study, we explored stress (ERS) protective effect asiatic acid (AA) HaCaT cells was found that key regulatory proteins ERS, such as glucose regulated...
The rural-urban gap in sociodemographic, lifestyle, and disease-related characteristics among COPD patients is prevalent. These differences may influence the prevalence of mild cognitive impairment (MCI). This study aimed to compare determinants MCI between rural urban areas patients.The cross-sectional sample comprised 372 from China. We evaluated function lung function, collected information, areas. Using multivariate regression analysis examine effects variables MCI.The was higher than...
Abstract Nitrogen mustard (NM) can alkylate nucleophilic proteins and DNA, causing severe cell damage. However, there are no reports on NM-induced proteomics dynamic changes. In this study, nuclear cytoplasmic of 16HBE were separated the components amounts detected analyzed. The amount DNA protein cross-linking (DPC) function p97 also explored. One-hour-NM-exposure caused a tremendous number entered into nucleus DPC formation. As repair progressed, exited. Although influx at 1 h was delayed...
There is currently no satisfactory therapy for nitrogen mustard (NM)-caused dermal toxicity, poor understanding of the exact mechanisms. Autophagy has been found to play important roles in physical or chemical exposure-caused cutaneous injuries. Herein, we initially confirmed that NM dose-dependently caused cell death keratinocytes. The LC3B2 (light chain 3 beta 2) formation and SQSTM1/p62 (sequestosome 1) degradation autophagosomes were also upregulated by NM. And chloroquine treatment...
Background: Medical defense against chemical, biological, radiological, and nuclear (CBRN) threats should be established through systematic education in college career development training to counter the response successfully. Methods: Taking course of Countermeasures CBRN Weapons is compulsorily for all military medical students Chinese People’s Liberation Army (PLA). In present study, a modularized field Chemical Defense Medicine provided, which an important part Integrated Military...