A5104226579- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Intermetallics and Advanced Alloy Properties
- Titanium Alloys Microstructure and Properties
- RNA modifications and cancer
- Antibiotic Resistance in Bacteria
- Advanced materials and composites
- Methane Hydrates and Related Phenomena
- Advanced biosensing and bioanalysis techniques
- Conducting polymers and applications
- Plant biochemistry and biosynthesis
- Genetic Mapping and Diversity in Plants and Animals
- Gut microbiota and health
- Aluminum Alloys Composites Properties
- RNA Research and Splicing
- Nasal Surgery and Airway Studies
- Shape Memory Alloy Transformations
- Soil Carbon and Nitrogen Dynamics
- MXene and MAX Phase Materials
- Quantum Dots Synthesis And Properties
- Nuclear Materials and Properties
- Plant Gene Expression Analysis
- Ferroptosis and cancer prognosis
- Geology and Paleoclimatology Research
- Cryospheric studies and observations
First People’s Hospital of Zunyi
2023-2025
Zunyi Medical University
2023-2025
Zhejiang University
2023-2025
Hubei University of Technology
2024-2025
Tianjin University of Science and Technology
2024-2025
Beijing Children’s Hospital
2024-2025
Capital Medical University
2024-2025
Qingdao University
2024-2025
Affiliated Hospital of Qingdao University
2024-2025
Guang’anmen Hospital
2024
We evaluated 25 protocol variants of 14 independent computational methods for exon identification, transcript reconstruction and expression-level quantification from RNA-seq data. Our results show that most algorithms are able to identify discrete components with high success rates but assembly complete isoform structures poses a major challenge even when all constituent elements identified. Expression-level estimates also varied widely across methods, based on similar models. Consequently,...
The hole-transporting material (HTM), poly (3,4-ethylene dioxythiophene) poly(styrene sulfonate) (PEDOT : PSS), is the most widely used in realization of high-efficiency organic solar cells (OSCs). However, stability PEDOT PSS-based OSCs quite poor, arising from its strong acidity and hygroscopicity. In addition, PSS has an absorption infrared region high highest occupied molecular orbital (HOMO) energy level, thus limiting enhancement short-circuit current density (J
Abstract In the fabrication of inverted perovskite solar cells (PSCs), wettability, adsorbability, and compactness self‐assembled monolayers (SAMs) on conductive substrates have critical impacts quality films defects at buried perovskite‐substrate interface, which control efficiency stability devices. Herein, three bisphosphonate‐anchored indolocarbazole (IDCz)‐derived SAMs, IDCz‐1, IDCz‐2, IDCz‐3, are designed synthesized by modulating position two nitrogen atoms IDCz unit to improve...
Abstract Taking into account the need for energy conservation, achieving near‐zero loss, namely ultrahigh efficiency ( η ), in storage capacitors with large recoverable density W rec ) plays an important role applications, which is one of major challenges dielectric field. Here, guided by phase‐field simulation, inhomogeneous polarization configuration multiple symmetries and magnitudes controlled through aliovalent strongly polar double ion design to establish a disordered state. A...
Chronic inflammation can delay wound healing, eventually leading to tissue necrosis and even cancer. Developing real-time intelligent monitoring treatment achieve effective management is important promote healing. In this study, a smart multifunctional hydrogel (Hydrogel@Au NCs&DG) was proposed monitor treat the inflammation. It prepared by mixing 3-carboxy-phenylboronic acid modified chitosan (CS-cPBA), β-glycerophosphate (β-GP), albumin-protected gold nanoclusters (BSA-Au NCs), dipotassium...
A total of 87 new monoclinic silicon allotropes are systematically scanned by a random strategy combined with group and graph theory high-throughput calculations. The include 13 direct or quasi-direct band gap 12 metallic characteristics, the rest indirect semiconductors. More than 30 these novel Si show bulk moduli greater equal to 80 GPa, three them even diamond Si. Only two shear modulus crystal structures, stability (elastic constants, phonon spectra), mechanical properties, electronic...
Flavonoids have always been considered as the chemical basis for hypoglycemic effect of mulberry leaves. In course our search agents from natural sources, a systematic study was launched to explore prenylated flavonoids Herein, investigation led isolation 10 characteristic flavonoids, including two new compounds (1 and 3). Their structures were elucidated based on spectroscopic data. All exhibited good α-glucosidase inhibitory activity in vitro, among which compound 2 had best (IC50 = 2.6...
Although single-cell multi-omics technologies are undergoing rapid development, simultaneous transcriptome and proteome analysis of a individual still faces great challenges. Here, we developed (scSTAP) platform based on microfluidics, high-throughput sequencing, mass spectrometry technology to achieve deep joint quantitative at the level, providing an important resource for understanding relationship between transcription translation in cells. This was applied analyze single mouse oocytes...
Abstract The hole‐transporting material (HTM), poly (3,4‐ethylene dioxythiophene) poly(styrene sulfonate) (PEDOT : PSS), is the most widely used in realization of high‐efficiency organic solar cells (OSCs). However, stability PEDOT PSS‐based OSCs quite poor, arising from its strong acidity and hygroscopicity. In addition, PSS has an absorption infrared region high highest occupied molecular orbital (HOMO) energy level, thus limiting enhancement short‐circuit current density ( J sc )...
Abstract Non-small cell lung cancer (NSCLC), characterized by low survival rates and a high recurrence rate, is major cause of cancer-related mortality. Aberrant activation the PI3K/AKT/mTOR signaling pathway common driver NSCLC. Within this study, inhibitory activity (+)-anthrabenzoxocinone ((+)-ABX), an oxygenated anthrabenzoxocinone compound derived from Streptomyces, against NSCLC demonstrated for first time both in vitro vivo. Mechanistically, it confirmed that targeted suppressed...
Background: How colorectal cancer (CRC) gain the ability to growth and metastasis remains largely unknown. Findings from preceding studies have revealed participation of long non-coding RNAs (lncRNAs) in CRC progression. However, role LINC01977 unexplored. This study aims explore function underlying mechanism CRC. Methods: The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) datasets were used analyze expression its correlation with prognosis. In our research, we explored influence...
Currently, there is no clinical data reported on the therapy of dual biological agents in pediatric-onset inflammatory bowel disease (PIBD) patients China. The purpose this study was to evaluate efficacy and safety biologic or biologics combined with small molecule drugs refractory PIBD Clinical, laboratory, endoscopic, ultrasound from Department Gastroenterology Beijing Children's Hospital between January 2021 October 2024 were retrospectively analyzed. who received treatment a combination...
Abstract The efficacy of cancer immunotherapy is significantly influenced by the heterogeneity individual tumors and immune responses. To investigate this phenomenon, a microfluidic platform constructed for profiling immune‐cancer cell interactions at single‐cell proteomics level first time. Based on platform, comprehensive workflow proposed achieving accurate pairing an with low damage high success rate up to 95%, pair co‐culture, real‐time microscopic monitoring cell‐pair interactions,...
ABSTRACT Burn wounds care and healing are very difficult in clinic. Herein, a multifunctional waterproof hydrogel was fabricated with photothermal antimicrobial NO anti‐inflammatory properties. In the as‐prepared hydrogel, polyethyleneimine (PEI) thioctic acid (TA) were cross‐linked by electrostatic interactions hydrogen bonding while aggregation of TA could be favor to formation hydrophobic caves. Benefit from caves, CuS BNN6 (N, N′‐dibutyl‐N, N′‐dinitroso‐1,4‐phenylenediamine) incorporated...
Purpose: To assess the feasibility and efficacy of sustained-release rapamycin-eluting metal stent in repair thermal injury-induced ureteral stricture mini-pigs explore its underlying mechanisms. Materials Methods: A total 18 female were used this study. At 1 month after effective establishment model, they randomly divided into normal control, bare-metal stent, groups. Before at 4 weeks placement, all animals underwent retrograde ureterography single-photon emission computed tomography....
This study aims to investigate the diagnostic accuracy of various deep learning methods on DCE-MRI, in order provide a simple and accessible tool for predicting pathologic response NAC breast cancer patients. In this study, we enrolled 313 patients who had complete DCE-MRI data underwent followed by surgery. According Miller-Payne criteria, efficacy was categorized into two groups: achieved grade 1-3 criteria were classified as non-responders, while 4-5 responders. Multiple frameworks,...
H2S can influence people's health and life even at low concentrations. The development of probes via a facile green strategy is still challenge due to the expense efficiency. Herein, colorimetric probe with good selectivity, high sensitivity, rapid response was prepared based on celastrol (CST), which an extract from Tripterygium wilfordii Hook f. could affect UV-vis spectra probe, resulting in significant change color yellow colorless, endowing ability quantitatively visualize within 1 min....