A5000018759- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Higher Education and Teaching Methods
- Higher Education Learning Practices
- Cancer-related Molecular Pathways
- Extracellular vesicles in disease
- Pancreatic and Hepatic Oncology Research
- Cholesterol and Lipid Metabolism
- NF-κB Signaling Pathways
- Telomeres, Telomerase, and Senescence
- Autophagy in Disease and Therapy
- Metabolomics and Mass Spectrometry Studies
- Sirtuins and Resveratrol in Medicine
Soochow University
2019-2024
First Affiliated Hospital of Soochow University
2019-2024
Soochow University
2019
Accumulating evidence suggests that aerobic glycolysis is important for colorectal cancer (CRC) development. However, the underlying mechanisms have yet to be elucidated. B7-H3, an immunoregulatory protein, broadly overexpressed by multiple tumor types and plays a vital role in progression. In this study, we found overexpression of B7-H3 effectively increased rate glucose consumption lactate production, whereas knockdown had opposite effect. Furthermore, showed production promoting...
Abstract Tumor angiogenesis is a hallmark of cancer and involved in the tumorigenesis solid tumors. B7-H3, an immune checkpoint molecule, plays critical roles proliferation, metastasis diverse tumors; however, little known about biological functions molecular mechanism underlying B7-H3 regulating colorectal (CRC) angiogenesis. In this study, we first demonstrated that expression was significantly upregulated positively associated with platelet endothelial cell adhesion molecule-1 (CD31)...
Abstract Long noncoding RNAs (lncRNAs) have been investigated in multiple human cancers including gastric cancer (GC). Our research aims to explore the role of H19 aerobic glycolysis, proliferation, and immune escape GC cells. The expression samples was analyzed using Gene Expression Profiling Interactive Analysis, Omnibus data, real‐time quantitative PCR analysis. Relative quantification glucose consumption lactate production from cell supernatant were applied assess glycolysis Subcellular...
Abstract Background Genetic background plays an important role in the occurrence and development of gastric cancer (GC). With application genome-wide association study (GWAS), increasing number tumor susceptibility genes have been discovered. While little them can be further applicated clinical diagnosis treatment due to lack in-depth analysis. Methods A GWAS peripheral blood leukocytes from GC patients was performed identify obtain genetic data. In combination with a investigation, key SNP...
Abstract As an important modality for the local control of colorectal cancer (CRC), radiotherapy or neoadjuvant is widely applied in clinic, but radioresistance has become a major obstacle CRC radiotherapy. Here we reported that B7-H3, costimulatory molecule, associated with CRC. The expression B7-H3 was obviously increased cells after irradiation. enhanced promoted, while knockdown inhibited, colony formation and cell activity following radiation treatment. overexpression reduced S phase...
Emerging evidence suggests that cellular senescence induced by chemotherapy has been recognized as a new weapon for cancer therapy. This study aimed to research novel functions of B7-H3 in low dose doxorubicin (DOX) colorectal (CRC). Here, our results demonstrated knockdown promoted, while overexpression inhibited, DOX-induced senescence. dramatically enhanced the growth arrest CRC cells after low-dose DOX treatment, but had opposite effect. By RNA-seq analysis and western blot, we showed...
Background: How colorectal cancer (CRC) gain the ability to growth and metastasis remains largely unknown. Findings from preceding studies have revealed participation of long non-coding RNAs (lncRNAs) in CRC progression. However, role LINC01977 unexplored. This study aims explore function underlying mechanism CRC. Methods: The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) datasets were used analyze expression its correlation with prognosis. In our research, we explored influence...
Colorectal cancer (CRC) is one of the most common malignancies, and chemoresistance key obstacles in clinical outcome. Here, we studied function B7-H3 regulating cell cycle-mediated CRC. The ability was investigated via viability, clonogenicity, apoptosis cycle analysis vitro. Moreover, role B7-H3/CDC25A axis vivo xenograft tumor models by intraperitoneal injection oxaliplatin (L-OHP) CDC25A inhibitors. correlation between examined CRC patients immunohistochemistry (IHC) pathological...
Abstract Colorectal cancer (CRC) is the third most common malignancy worldwide. Circular RNAs (circRNAs) have been reported to play critical regulatory roles in tumorigenesis, serving as tumor biomarkers and therapeutic targets. However, contributions of circRNAs CRC tumorigenesis are unclear. In our study, high expression circLDLR was found tissues cells closely associated with malignant progression poor prognosis patients. We demonstrated that boosts growth metastasis vitro vivo, modulates...
Hypoxia plays an important role in the development of pancreatic cancer (PCA). However, there is few research on application hypoxia molecules predicting prognosis PCA. We aimed to establish a prognostic model based hypoxia-related genes (HRGs) for PCA discover new biomarkers, and reveal potential this evaluating tumor microenvironment (TME).Univariate Cox regression analysis was used identify HRGs associated with overall survival (OS) samples. A established least absolute shrinkage...
Background: Tumor angiogenesis is a hallmark of cancer and involved in the tumorigenesis solid tumors. B7-H3, an immune checkpoint molecule, plays critical roles proliferation, metastasis diverse tumors; however, little known about biological functions molecular mechanism underlying B7-H3 regulating colorectal (CRC) angiogenesis.Methods: Immunohistochemistry (IHC) was performed to evaluate expression CD31 VEGFA CRC tissue samples. The ability human umbilical vein endothelial cells (HUVECs)...
Tumor angiogenesis, a hallmark of cancer, is critical step in the tumorigenesis solid cancers. The process tumor angiogenesis orchestrated by range secreted factors, signaling pathways as well nonendothelial cells. Abnormal vascular networks sometimes contribute to decline efficacy various therapies, such chemotherapy, radiotherapy, and immunotherapy.
Abstract Background Long non-coding RNAs (lncRNAs) have been investigated in multiple human cancers including gastric cancer (GC). Our research aims to explore the role of H19 aerobic glycolysis, proliferation, and immune escape GC cells. Methods The expression samples were analyzed using Gene Expression Profiling Interactive Analysis (GEPIA), Omnibus (GEO) data, real-time quantitative polymerase chain reaction (RT-qPCR) analysis. Glucose consumption lactate production applied assess...