A5100604479- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Diabetes Treatment and Management
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Diabetes Management and Research
- Colorectal Cancer Treatments and Studies
- Cancer-related Molecular Pathways
- Pancreatic function and diabetes
- RNA modifications and cancer
- NF-κB Signaling Pathways
- Gastrointestinal Tumor Research and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
Soochow University
2013-2025
First Affiliated Hospital of Soochow University
2013-2025
Shandong University
2014-2024
Shandong Provincial QianFoShan Hospital
2014-2024
Shandong First Medical University
2020-2024
Sun Yat-sen University
2021
Guangzhou University of Chinese Medicine
2021
Zhongshan Hospital
2021
The First Affiliated Hospital, Sun Yat-sen University
2021
Wuxi People's Hospital
2021
Abstract Long noncoding RNAs (lncRNAs) have been investigated in multiple human cancers including gastric cancer (GC). Our research aims to explore the role of H19 aerobic glycolysis, proliferation, and immune escape GC cells. The expression samples was analyzed using Gene Expression Profiling Interactive Analysis, Omnibus data, real‐time quantitative PCR analysis. Relative quantification glucose consumption lactate production from cell supernatant were applied assess glycolysis Subcellular...
<h3>Importance</h3> Gastric neuroendocrine carcinoma and mixed adenoneuroendocrine are rare pathological types of gastric cancer, there is a lack multicenter studies comparing the prognosis recurrence patterns carcinoma, adenocarcinoma. <h3>Objective</h3> To compare differences in long-term survival among <h3>Design, Setting, Participants</h3> This cohort study included patients with resectable at 23 hospitals China from January 2006 to December 2016. In addition, adenocarcinoma were...
Abstract The Ras‐related protein RAB7A has been implicated in the development and prognosis of various cancers. This study aims to investigate prognostic significance colon adenocarcinoma (COAD). We conducted a retrospective cohort COAD cases assess expression its clinical relevance. chi‐square test was employed establish associations between features expression. Survival analyses, including Kaplan–Meier Cox regression, were evaluate impact characteristics on patient outcomes. Furthermore,...
Venous thromboembolism (VTE) is a common and serious complication after colorectal cancer (CRC) surgery. Few large-sample studies have reported VTE incidence management status CRC surgery in China. This study aimed to investigate the prevention of Chinese patients surgery, identify risk factors for developing VTE, construct new scoring system clinical decision-making care planning.Participants were recruited from 46 centers 17 provinces Patients followed up 1 month postoperatively. The...
Right hemicolectomy is the standard treatment for right-sided colon cancer. There variation in technical aspects of performing right as well short-term outcomes. It therefore necessary to explore best clinical practice following expert centres.
Metaplastic thymoma is a rare primary thymic epithelial tumor, and its biologic behavior uncertain. We report 7 cases of metaplastic thymoma. The spindle components the tumor seemed to be undergoing epithelial-mesenchymal transition, which characterized by loss E-cadherin expression. Epstein-Barr virus not have an etiologic role in No gross genetic alterations were found using comparative genomic hybridization. patients alive well follow-up ranging from 11 172 months (mean, 81.7 months)....
Diabetic nephropathy is the primary cause of end-stage renal disease. Apoptosis tubule epithelial cells a major feature diabetic nephropathy. The mechanisms high glucose (HG) induced apoptosis are not fully understood. Here we demonstrated that, HG via upregulating expression proapoptotic Bcl-2 homology domain 3 (BH3)-only protein Bim protein, but bring significant change in baseline level autophagy HK2 cells. increase was caused by ugregulation transcription factors, FOXO1 and FOXO3a....
Many studies have evaluated the association between matrix metalloproteinase 9 (MMP9) gene promoter polymorphism and diabetic microvascular complications. However, results are conflicting inconclusive. The aim of this meta-analysis was to evaluate more precisely.Studies were retrieved from PubMed, Embase, Medline, China National Knowledge Infrastructure, Web Science, Cochrane databases. All statistical analyses performed using Review Manager 5.2.Data abstracted four case-control that...
Context: Osthole [7-methoxy-8-(3-methyl-2-butenyl) coumarin] isolated from the fruit of Cnidium monnieri (L.) Cuss, one commonly used Chinese medicines listed in Shennong's Classic Materia Medica Han Dynasty, had remarkable antiproliferative activity against human hepatocellular carcinoma HepG2 cells culture.Objectives: This study evaluated effects osthole on cell growth, nuclear morphology, cycle distribution, and expression apoptosis-related proteins cells.Materials methods: Cytotoxic was...
Background: Although bariatric surgery performed for morbid obesity has been shown to significantly improve type 2 diabetes mellitus (T2DM), data on its effectiveness T2DM in nonobese patients are scarce. The present pilot study evaluated the clinical effects of laparoscopic Roux-en-Y gastric bypass (LRYGB) Chinese with body mass index (BMI) ≤27.5 kg/m2. Materials and methods: A total 68 consecutive uncontrolled underwent LRYGB from May 2010 March 2012. All were subjected follow-up controls...
CHIP is an E3 ubiquitin ligase that plays contrast roles in diverse human malignancies, depending on its targets. To date, the mechanisms underlying function of gastric cancer remains unclear. Here, we aim to further clarify effects development and progression explore potential target. Stably transfected CHIP-shRNA TRAF2-shRNA AGS cell lines were established using Lipofectamine 2000. Cell growth was measured by xCelligence real-time monitoring system colony formation assay. proliferation...
Nuclear transcription factor kappa B (NF-κB) subunits exhibit crucial roles in tumorigenesis and chemo-sensitivity. Recent studies suggest that RelB, the key subunit of alternative NF-κB pathway, plays a critical role progression diverse human malignancies. However, significance RelB colorectal cancer (CRC) remains unclear. Here, we systematically explored functions colon cells its underlying mechanism.Stably transfected RelB-shRNA DLD-1 were established using Lipofectamine 2000. DNA-binding...
Gastric cancer (GC) is among the most prevalent causes of cancer-related death globally. MiR-223 has been implicated in a variety cellular mechanisms linked to progression. However, miR-223 expressions and its function GC are unknown. We discovered that expression was raised tissues comparison with nearby normal this investigation. Additionally, multiplied strongly TNM stage (p=0.022), live metastasis (p=0.004),lymph node (p=0.004),and Borrmann type associated an unfavorable prognostic for...