A5101690421- Diabetes Treatment and Management
- COVID-19 Clinical Research Studies
- Burn Injury Management and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Electrolyte and hormonal disorders
- Herpesvirus Infections and Treatments
- SARS-CoV-2 detection and testing
- DNA and Nucleic Acid Chemistry
- Biomedical and Chemical Research
- Mast cells and histamine
- Metabolism, Diabetes, and Cancer
- Electroconvulsive Therapy Studies
- Alcohol Consumption and Health Effects
- Alzheimer's disease research and treatments
- Muscle and Compartmental Disorders
- Tissue Engineering and Regenerative Medicine
- Diabetes and associated disorders
- Advanced Glycation End Products research
- Chemokine receptors and signaling
- Diabetic Foot Ulcer Assessment and Management
- HER2/EGFR in Cancer Research
- Adipokines, Inflammation, and Metabolic Diseases
- Lung Cancer Treatments and Mutations
- Organophosphorus compounds synthesis
- Pancreatic function and diabetes
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Shandong University
2013-2024
Shanghai Innovative Research Center of Traditional Chinese Medicine
2022
Qilu Hospital of Shandong University
2015
National Institutes of Health
1990-2004
National Institutes of Health Clinical Center
2004
National Institute of Mental Health
2004
First Affiliated Hospital of Chinese PLA General Hospital
1989-2000
Yale University
1990-1993
Nirmatrelvir-ritonavir has been authorized for emergency use by many countries the treatment of coronavirus disease 2019 (Covid-19). However, supply falls short global demand, which creates a need more options. VV116 is an oral antiviral agent with potent activity against severe acute respiratory syndrome 2 (SARS-CoV-2).We conducted phase 3, noninferiority, observer-blinded, randomized trial during outbreak caused B.1.1.529 (omicron) variant SARS-CoV-2. Symptomatic adults mild-to-moderate...
Phosphorothioate oligodeoxycytidine (S-dCn) was used as a model compound to examine the impact of number phosphorothioate linkages and their position on inhibition human DNA polymerases RNase H in vitro. S-dCn with chain length longer than 15 could inhibit activities, linkage number-dependent manner. Longer oligomers were more potent inhibitors shorter ones. Kinetic studies indicated that S-dC28 competitive inhibitor polymerase alpha beta respect template, whereas it noncompetitive gamma...
Importance With the widespread use of anti–SARS-CoV-2 drugs, accumulating data have revealed potential viral load rebound after treatment. Objective To compare COVID-19 a standard 5-day course antiviral treatment with VV116 vs nirmatrelvir-ritonavir. Design, Setting, and Participants This is single-center, investigator-blinded, randomized clinical trial conducted in Shanghai, China. Adult patients mild-to-moderate within 5 days SARS-CoV-2 infection were enrolled between December 20, 2022,...
Phosphorothioate homo-oligodeoxynucleotides were found to be potent inhibitors of herpes simplex virus type 2 (HSV-2) but less for HSV-1 in cell culture studies. Oligomers with longer chain lengths more active against HSV-2 than those shorter ones. Of all the compounds examined, 28-mer phosphorothioate strongest HSV-2. The degree inhibition was related base moiety on order deoxycytidine = thymidine greater deoxyadenosine. growth by S-dC28 dose dependent a 90% inhibitory 1 microM. At 50...
The uptake and distribution of phosphorothioate oligodeoxynucleotides by human cells were studied using 35S-labeled 28-mer oligodeoxycytidine [S-(dC)28]. Accumulation intracellular S-(dC)28 was found to be higher in the carcinoma (grown monolayers) than leukemia suspension culture). A hepatoma cell line transfected with hepatitis B virus, 2215, chosen for further studies. partially dependent on temperature energy. concentration significantly that medium amount accumulated extracellular...
This study evaluated (18)F-labeled IMPY [6-iodo-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine] derivatives as agents for imaging beta-amyloid plaque with positron emission tomography (PET). The precursor radiolabeling and reference compounds was synthesized in up to five steps from commercially accessible starting materials. One of the two N-methyl groups substituted either a 3-fluoropropyl (FPM-IMPY) or 2-fluoroethyl (FEM-IMPY) group. FPM-IMPY FEM-IMPY were found have moderate...
The 28-mer phosphorothioate oligodeoxycytidine (S-(dC)28) has been reported previously to be a strong inhibitor of herpes simplex virus type 2 (HSV-2) DNA polymerase and HSV-2 growth in cell culture. In this study, the mechanism action S-(dC)28 was studied. found interfere with adsorption HSV-1 HeLa cells. infection, but not HSV-1, potentiate uptake into enhanced reached plateau at 6-9 h postinfection appeared dose-dependent saturable concentrations higher than 1 microM. amount accumulated...
Many studies have evaluated the association between matrix metalloproteinase 9 (MMP9) gene promoter polymorphism and diabetic microvascular complications. However, results are conflicting inconclusive. The aim of this meta-analysis was to evaluate more precisely.Studies were retrieved from PubMed, Embase, Medline, China National Knowledge Infrastructure, Web Science, Cochrane databases. All statistical analyses performed using Review Manager 5.2.Data abstracted four case-control that...
We have given whole blood as one of the main constituents burn shock resuscitation for past 28 years. To appraise value using blood, we summarized clinical experience 2630 patients. Overall mortality was 4.18%. The lethal area were 50% population is expected to die 82.8% total body surface and 57.4% third-degree burns. incidence renal failure, pulmonary edema, gastrointestinal bleeding 0.9%, 0.4%, 0.6% respectively. confirm advantage transfusion carried out a series experimental studies. Two...
Uric acid and blood glucose are important indicators of metabolic disorders. Numerous studies have elucidated the association between them, but focus on their relationship through examination urinary uric excretion has been limited. In this study, we conducted a comprehensive analysis these to explain relationship.