A5013332949- Colorectal Cancer Surgical Treatments
- Minimally Invasive Surgical Techniques
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Extracellular vesicles in disease
- Biochemical and Molecular Research
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Hernia repair and management
- Gastrointestinal Tumor Research and Treatment
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Diverticular Disease and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Protein Tyrosine Phosphatases
- Circadian rhythm and melatonin
- Innovative Educational Techniques
- Ferroptosis and cancer prognosis
- Sleep and related disorders
- Inflammatory Biomarkers in Disease Prognosis
- Enhanced Recovery After Surgery
- Angiogenesis and VEGF in Cancer
Ruijin Hospital
2012-2024
University of California, Berkeley
2024
Shanghai Jiao Tong University
2012-2024
Zhengzhou University of Industrial Technology
2016
Shanghai First People's Hospital
2015
Affiliated Hospital of Qingdao University
2008
Qingdao University
2008
Nirmatrelvir-ritonavir has been authorized for emergency use by many countries the treatment of coronavirus disease 2019 (Covid-19). However, supply falls short global demand, which creates a need more options. VV116 is an oral antiviral agent with potent activity against severe acute respiratory syndrome 2 (SARS-CoV-2).We conducted phase 3, noninferiority, observer-blinded, randomized trial during outbreak caused B.1.1.529 (omicron) variant SARS-CoV-2. Symptomatic adults mild-to-moderate...
Intraoperative and transdermal ultrasonography-mediated brachytherapy has been proved to be effective in postponing the development of abdominal carcinomas. The main purpose this study was evaluate clinical efficacy safety endoscopic ultrasonography (EUS)-guided interstitial implantation radioactive iodine 125 seeds advanced pancreatic cancer.In total, 22 patients with cancer positive fine-needle aspiration results underwent EUS-guided seeds. All enrolled received routine gemcitabine-based...
体育素养的发展对个体的长期健康至关重要，其素质可以描述为一个人愿意运用运动的潜力来提升生活质量的动机和能力。高校体育课程是培养体育素养的关键，有必要帮助因疾病无法参与剧烈运动的学生参与体育活动，促进心理健康。本研究以体育素养基本策略为基础，运用PBL教学模式，对在必修体育课上学习疾病的大学生进行为期10周的课程干预。结果显示，干预组在10周后体育素养得分和体育学习兴趣得分显著高于遵循传统课程模式的对照组，虽然有所提高，但差异不具有统计学意义。本研究的课程干预方案不仅为高校体育教育提供了参考，也为促进青少年体育素养发展、建立优质的学校体育课程提供了切实可行的方案。
ETS transcription factors play important roles in tumor cell invasion, differentiation and angiogenesis. In this study, we initially demonstrated that translocation variant 5 (ETV5) is abnormally upregulated colorectal cancer (CRC), positively correlated with CRC size, lymphatic metastasis node (TNM) stage indicates shorter survival disease-free patients. vitro vivo experiments revealed the downregulation of ETV5 could significantly suppress proliferation. Moreover, overexpression stimulate...
Nucleotide supply is essential for DNA replication in proliferating cells, including cancer cells. Ribose-phosphate diphosphokinase 1 (PRPS1) a key enzyme to produce the consensus precursor of nucleotide synthesis. PRPS1 participates pentose phosphate pathway (PPP) by catalyzing phosphoribosylation D-ribose 5-phosphate (R-5P) 5-phosphoribosyl-1-pyrophosphate. Therefore, not only controls purine biosynthesis and supplies precursors RNA but also regulates PPP through feedback loop substrate...
Abstract Background Colorectal cancer (CRC) is a leading and major cause of death. Lipopolysaccharide (LPS), an abundant component in gut microbiome, involved CRC progression metastasis, potentially through regulating the miRNA composition CRC-derived exosomes. In this study, we aimed to identify species exosome which regulates after LPS stimulation. Results Firstly, discovered shift profile Among differentially expressed miRNAs, identified miR-200c-3p as potential key regulator metastasis....
Here, the discussion focused on function and possible mechanism of cancer stem cell-like cells (CSCs)-derived exosomal CDKN2B-AS1 in thyroid cancer.Specifically, bioinformatics analysis, dual-luciferase reporter assay RT-qPCR were conducted to obtain expression regulation CDKN2B-AS1, downstream miR-122-5p/P4HA1 axis. Exosomes identified by transmission electron microscopy. The uptake exosome recipient was observed PKH67 labeling. Functional experiments western blot adopted detect effects...
Abstract Background In recent years, the differences between left-sided colon cancer (LCC) and right-sided (RCC) have received increasing attention due to clinicopathological variation them. However, some of these remained unclear conflicting results been reported. Methods From The Cancer Genome Atlas (TCGA), we obtained RNA sequencing data gene mutation on 323 283 patients, respectively. Differential analysis was firstly done expression LCC RCC, separately. Machine learning (ML) methods...
Recently, enhanced recovery after surgery (ERAS) has been widely used in the perioperative management of colorectal cancer (CRC). This study aimed to evaluate safety and feasibility ERAS combined with single-incision laparoscopic (SILS) CRC surgery.This was a retrospective patients who underwent between April 2018 2020 Ruijin Hospital(North), Shanghai Jiaotong University School Medicine. The were divided into three groups: group A (n=138), traditional multiport colectomy conventional...
Abstract Background In most previous studies, single-incision laparoscopic surgery (SILS) for colorectal cancer (CRC) was feasible and safe in the short term. However, long-term oncologic outcomes remain uncertain, as only a few studies contained survival data. SILS CRC is still early stages of research. Further particularly large-scale, prospective randomized controlled trials, are necessary to assess value CRC. Methods This study prospective, multicentre, open-label, noninferiority,...
We performed a 1-year cluster-randomized field trial to assess the effect of standardized management chronic obstructive ©FUNPEC-RP www.funpecrp.com.brGenetics and Molecular Research 14 (3): 8861-8870 (2015) pulmonary disease (COPD) on lung function quality life (QOL) measures in patients China.We used Global Initiative for Chronic Obstructive Lung Disease (GOLD) treatment guidelines assessed indexes including function, QOL, quality-adjusted years (QALY), Medical Council (MRC) dyspnea scale,...
Pure transvaginal natural orifice transluminal endoscopic surgery right hemicolectomy for colon cancer: A case report
To date, well-designed randomized controlled trials examining the safety, efficacy, and long-term outcomes of single-incision laparoscopic surgery (SILS) for colorectal cancer are scarce. The aim current study was to compare short-term SILS with conventional (CLS).Between June 28, 2017, 29, 2019, a single-center, open-label, non-inferiority, clinical trial conducted at Department General Surgery, Ruijin Hospital (North), Shanghai Jiaotong University School Medicine in Shanghai, China. In...
AF4/FMR2 family member 4 (AFF4) is a core component of super elongation complex (SEC) and regulates the transcription many genes. AFF4 depletion or amplification associated with multiple cancers, but its role in colorectal cancer (CRC) has not been investigated so far.qRT-PCR Western blot analyzed expression paired clinical CRC tissues. The patients' overall survival curve was determined using Kaplan-Meier plotter. In vitro experiments, such as cell proliferation, migration, invasion, were...
Abstract Background Anti‐PD1/PD‐L1 antibody plus human epidermal growth factor receptor 2 (HER2) and chemotherapy have become the new first‐line therapy for HER2 overexpression‐positive advanced gastric cancers (GC), suggesting that PD‐L1 play a vital role in guiding systemic treatment patients with GC. This study aimed to depict genomic immune landscapes of Chinese GC investigate their correlations amplification expression. Patients Methods Next‐generation targeted sequencing...
To report the feasibility of laparoscopic resection with intraoperative radiotherapy for local advanced rectal cancer in an Asian man.A 55-year-old man adenocarcinoma rectum presented at Ruijin Hospital, Shanghai Jiaotong University School Medicine, Shanghai, China. The tumor, a size 5 × cm, was located 3 cm from anus and covered circular area around approximately two-thirds bowel. carcinoembryonic antigen level 29.86 ng/mL; nodule detected, but no distant metastasis detected. Preoperative...