A5004248524- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- Advanced biosensing and bioanalysis techniques
- Cancer, Lipids, and Metabolism
- Birth, Development, and Health
- Facial Trauma and Fracture Management
- Maternal and Perinatal Health Interventions
- Dental Radiography and Imaging
- COVID-19 epidemiological studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug Transport and Resistance Mechanisms
- Protein Degradation and Inhibitors
- Pregnancy and preeclampsia studies
- Salivary Gland Tumors Diagnosis and Treatment
- Facial Rejuvenation and Surgery Techniques
- Statistical Methods in Clinical Trials
- Reproductive Biology and Fertility
- Histone Deacetylase Inhibitors Research
- Optimal Experimental Design Methods
- Lymphatic System and Diseases
- Gestational Diabetes Research and Management
- Head and Neck Surgical Oncology
- Cancer, Hypoxia, and Metabolism
- Cleft Lip and Palate Research
- Health Systems, Economic Evaluations, Quality of Life
Shanghai Jiao Tong University
2016-2025
Stomatology Hospital
2024
Sun Yat-sen University
2007-2024
Hospital of Stomatology, Sun Yat-sen University
2024
International Peace Maternity & Child Health Hospital
2024
Peking University Third Hospital
2023-2024
Peking University
2023-2024
Clinical Research Institute
2020-2023
Shanghai Institute of Hematology
2023
Zhengzhou University
2022
Rates of caesarean section are concern in both developed and developing countries. We set out to estimate the proportion births by (CS) at national, regional global levels, describe subregional patterns correlate rates with other reproductive health indicators. analysed nationally representative data available from surveys or vital registration systems on CS. used local non-parametric regression techniques CS maternal mortality ratio, infant neonatal rates, attended skilled personnel....
To enhance therapeutic efficacy and reduce adverse effects, practitioners of traditional Chinese medicine (TCM) prescribe a combination plant species/minerals, called formulae, based on clinical experience. Nearly 100,000 formulae have been recorded, but the working mechanisms most remain unknown. In trying to address possible beneficial effects with current biomedical approaches, we use Realgar-Indigo naturalis formula (RIF), which has proven be very effective in treating human acute...
Significance Acute myeloid leukemia (AML) consists of a group hematopoietic malignancies with considerable diversities in clinical and biological features. Recently, not only genetic abnormalities but also “oncometabolites,” such as 2-hydroxyglutarate (2-HG), have been found to play role driving AML pathogenesis serve potential disease markers. In this study on large cohort AML, we that the serum 2-HG level was increased 62 367 (17%) cases distinct hematologic Survival analysis performed 234...
Background & aimsEpidemiologic studies have revealed that early-life conditions influence later risk of chronic diseases. We aimed to explore whether exposure Chinese famine between 1959 and 1962 during fetal childhood period was related with metabolic syndrome (MS) in adulthood.Methods6445 subjects from SPECT-China study were divided into fetal-exposed (1959–1962), childhood-exposed (1949–1958), adolescence/young adult-exposed (1921–1948), non-exposed (1963–1974) (after 1975). MS defined by...
Drug-induced liver injury (DILI) is complicated and difficult to predict. It has been observed that drugs with extensive hepatic metabolism have a higher likelihood of causing DILI. Cytochrome P450 (P450) enzymes are primarily involved in metabolism. Identifying the associations DILI substrates, inhibitors, or inducers will be extremely helpful clinicians during decision-making process caring for patient suspected having We collected data on 254 orally administered Liver Toxicity Knowledge...
The Chinese were afflicted by great famine between 1959 and 1962. These people then experienced rapid economic development during which the gross domestic product per capita increased from $28 in 1978 to $6807 2013. We hypothesize that these two events are associated with booming rate of diabetes China.We aimed explore whether exposure early life high status adulthood was later life.Our data 6897 adults a cross-sectional Survey on Prevalence East China for Metabolic Diseases Risk Factors...
Epidemiologic studies have indicated that early life nutrition influences later risk of obesity, type 2 diabetes, and metabolic syndrome. Nonalcoholic fatty liver disease (NAFLD) is also considered a disease.
Significance The APL2012 trial is currently the largest randomized, multicenter clinical study of APL based on ATRA-ATO treatment with risk stratification. We enrolled 855 newly diagnosed patients during December 2012 to 2017 for careful follow-up. All received ATRA-ATO–based protocols remission induction. At consolidation phase, key part trial, ATO was used replace or reduce chemotherapy in a risk-stratified way. Patients were then treated as maintenance. results indicated not only...
Background Cyclin D1 (CCND1) has been associated with chemotherapy resistance and poor prognosis. In this study, we tested the hypothesis that CCND1 expression determines response clinical outcomes in locally advanced head neck squamous cell carcinoma (HNSCC) patients treated neoadjuvant followed by surgery radiotherapy. Methodology Findings 224 HNSCC were either cisplatin-based radiotherapy (neoadjuvant group, n = 100) or (non-neoadjuvant 124). was assessed immunohistochemistry. levels...
Abstract Background Lymphoscintigraphy is widely used to image the lymphatic system. The aim of this study was compare lymphoscintigraphy and dynamic magnetic resonance lymphangiography (MRL) in investigation extremity lymphoedema. Methods Sixteen patients with primary lymphoedema two Klippel–Trenaunay syndrome were examined by using tracer 99Tc-labelled dextran, MRL gadobenate dimeglumine as contrast agent. Morphological abnormalities functional state systems affected limbs compared between...
A Williams design is a special and useful type of cross-over design. Balance achieved by using only one particular Latin square if there are even numbers treatments, two appropriate squares odd treatments. PROC PLAN SAS/STAT practical tool, not for random construction the square, but also randomly assigning treatment sequences to subjects, which makes integration procedures possible. The present paper provides general SAS program relevant procedure randomization. Examples three-treatment,...
Rates of caesarean section are progressively increasing in many parts the world. As a result psychosocial factors there has been an tendency for pregnant women without justifiable medical indications to ask this procedure China. A critical examination issue relation maternal outcomes is important. At present no clinical trials help assess risks and benefits low risk women. To fill gap left by trials, indication-matched cohort study was carried out examine prospectively on with absolute...
There is growing evidence that angiotensin-converting enzyme 2 highly expressed on endothelial cells, dysfunction plays a critical role in coronavirus disease 2019 (COVID-19) progression, but laboratory still lacking. This study established multicenter retrospective cohort of 966 COVID-19 patients from three hospitals Wuhan, China. We found male (62.8% vs. 46.5%), old age [72 (17) 60.5 (21)], and coexisting chronic diseases (88.5% 60.0%) were associated with poor clinical prognosis COVID-19....
Background/Objectives: Observational studies have suggested a correlation between brain imaging alterations and Parkinson’s disease (PD). However, data on causal relationships are still lacking. This study aimed to examine the relationship imaging-derived phenotypes (IDPs) PD. Methods: A bidirectional two-sample Mendelian randomization analysis was conducted explore association IDPs Summary-level for (n=39,691), PD (n=482,730), symptoms (n=4,093) were obtained from genome-wide of European...
Background/Objectives: Observational studies have suggested a correlation between brain imaging alterations and Parkinson’s disease (PD). However, data on causal relationships are still lacking. This study aimed to examine the relationship imaging-derived phenotypes (IDPs) PD. Methods: A bidirectional two-sample Mendelian randomization analysis was conducted explore association IDPs Summary-level for (n = 39,691), PD 482,730), symptoms 4093) were obtained from genome-wide of European...
Background Poor postoperative wound healing after endoscopic sinus surgery (ESS) remains a significant problem. This study evaluates the efficacy and safety of new absorbable hyaluronan hydrogel. Methods A prospective, randomized, controlled trial was conducted. Fifty-five patients with bilateral ESS were recruited randomized to receive hydrogel in one side as treated opposite without control. Clinical outcome measures assessed at 1, 2, 4, 8, 12 weeks. Results Fifty-four completed study....
Brain arteriovenous malformations (AVMs) are the most common cause of nontraumatic intracerebral hemorrhage in young adults. The genesis brain AVM remains enigmatic. We investigated microRNA (miRNA) expression and its contribution to pathogenesis AVMs.We used a large-scale miRNA analysis 16 samples including AVMs, hemangioblastoma, controls identify distinct signature. smooth muscle cells (AVMSMCs) were isolated identified by flow cytometry immunohistochemistry, candidate miRNAs then tested...