A5100700253- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Advanced biosensing and bioanalysis techniques
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Platelet Disorders and Treatments
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Antioxidant Activity and Oxidative Stress
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Blood groups and transfusion
- Eosinophilic Disorders and Syndromes
- Neutropenia and Cancer Infections
- RNA modifications and cancer
Changhai Hospital
2024-2025
Second Military Medical University
2024-2025
Daping Hospital
2025
Army Medical University
2025
Northwestern Polytechnical University
2025
Shanxi Medical University
2025
Tianjin Centers for Disease Control and Prevention
2024
Ruijin Hospital
2015-2024
Shanghai Jiao Tong University
2015-2024
Shanghai Institute of Hematology
2015-2024
Both all-trans retinoic acid (ATRA) and arsenic trioxide (As(2)O(3)) have proven to be very effective in obtaining high clinical complete remission (CR) rates acute promyelocytic leukemia (APL), but they had not been used jointly an integrated treatment protocol for induction or maintenance among newly diagnosed APL patients. In this study, 61 subjects were randomized into three groups, namely by ATRA, As(2)O(3), the combination of two drugs. CR was determined hematological analysis, tumor...
All-trans retinoic acid (ATRA)/arsenic trioxide (ATO) combination-based therapy has benefitted newly diagnosed acute promyelocytic leukemia (APL) in short-term studies, but the long-term efficacy and safety remained unclear. From April 2001, we have followed 85 patients administrated ATRA/ATO with a median follow-up of 70 months. Eighty (94.1%) entered complete remission (CR). Kaplan-Meier estimates 5-year event-free survival (EFS) overall (OS) for all were 89.2% +/- 3.4% 91.7% 3.0%,...
Significance Multiple myeloma (MM) is one of the most common hematological malignancies. Developing an effective treatment strategy for refractory/relapsed (R/R) MM represents a major challenge. In this trial, 17 R/R patients, who had previously experienced multiple lines treatments, received chimeric antigen receptor modified T (CAR T) cell preparation targeting two epitopes BCMA, and remarkable overall response 88.2% was achieved. This work confirms feasibility importance CAR therapy in...
Genomic landscapes of 92 adult and 111 pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) were investigated using next-generation sequencing copy number alteration analysis. Recurrent gene mutations fusions tested in an additional 87 93 patients. Among the 29 newly identified in-frame fusions, those involving MEF2D ZNF384 clinically relevant demonstrated to perturb differentiation, EP300-ZNF384 inducing mice. Eight expression subgroups associated characteristic genetic...
Metformin is a commonly used drug for the treatment of diabetes. Accumulating evidence suggests that it exerts anti-tumor effects in many cancers, including multiple myeloma (MM); however, underlying molecular mechanisms have not been clearly elucidated. The anti-myeloma metformin were evaluated using human MM cell lines (RPMI8226 and U266) vitro vivo NOD-SCID murine xenograft model. Cell viability was assessed with CCK8 proliferation measured by EdU incorporation assay. cycle distribution...
Significance Acute myeloid leukemia (AML) consists of a group hematopoietic malignancies with considerable diversities in clinical and biological features. Recently, not only genetic abnormalities but also “oncometabolites,” such as 2-hydroxyglutarate (2-HG), have been found to play role driving AML pathogenesis serve potential disease markers. In this study on large cohort AML, we that the serum 2-HG level was increased 62 367 (17%) cases distinct hematologic Survival analysis performed 234...
Significance Anthracyclines like doxorubicin are anticancer drugs, used by over 1 million cancer patients annually. However, they cause severe side effects, most notably, cardiotoxicity and therapy-related malignancies. It is unclear whether these effects directly linked to their activity. Doxorubicin exerts two activities: DNA damage chromatin damage. Here, we show that both activities conspire in the cardiotoxicity, while variants with only chromatin-damaging activity remain active drugs...
We developed a visual and rapid reverse transcription–loop-mediated isothermal amplification (RT-LAMP) assay targeting the S gene for SARS-CoV-2 infection. The strength of our study was that we validated RT-LAMP using 481 clinical respiratory samples from two prospective cohorts suspected COVID-19 patients on serial an asymptomatic carrier. approach showed increased sensitivity (88.89%) high consistency (kappa, 0.92) compared with those transcription-quantitative PCR (RT-qPCR) screening...
Abstract Purpose: NOTCH signaling pathway is essential in T-cell development and NOTCH1 mutations are frequently present acute lymphoblastic leukemia (T-ALL). To gain insight into its clinical significance, mutation was investigated 77 patients with T-ALL. Experimental Design: Detection of done using reverse transcription-PCR amplification direct sequencing, thereby compared according to the clinical/biological data patients. Results: Thirty-two were identified 29 (with dual 3 cases),...
Acute myeloid leukemia (AML) is a life-threatening hematological disease. Novel diagnostic and prognostic markers will be essential for new therapeutics significantly improving the disease prognosis. To characterize metabolic features associated with AML search potential methods, here we analyzed phenotypic characteristics of serum metabolite composition (metabonome) in cohort 183 patients de novo acute together 232 age- gender-matched healthy controls using (1)H NMR spectroscopy conjunction...
RA-inducible gene I (RIG-I/DDX58) has been shown to activate IFN-β promoter stimulator 1 (IPS-1) on recognizing cytoplasmic viral RNAs. It is unclear how RIG-I functions within the IFN and/or RA signaling process in acute myeloid leukemia (AML) cells, however, where obvious induction observed. Here, we show that functionally contributes IFN-α plus RA-triggered growth inhibition of AML cells. Interestingly, although itself under regulation STAT1, a major intracellular signal mediator,...
Homoharringtonine (HHT), a known protein synthesis inhibitor, has an anti-myeloid leukemia effect and potentiates the therapeutic efficacy of anthracycline/cytarabine induction regimens for acute myelogenous (AML) with favorable intermediate prognoses, especially in t(8;21) subtype. Here we provide evidence showing that HHT inhibits activity leukemia-initiating cells (Lin − /Sca-1 /c-kit + ; LICs) murine model exerts down-regulating on MYC pathway genes human (Kasumi-1). We discovered NF-κB...
Summary Eltrombopag, a thrombopoietin receptor agonist, raises platelet counts and reduces bleeding in patients with immune thrombocytopenia ( ITP ). In Chinese patients, eltrombopag was evaluated at an initial dose of 25 mg, vs. 50 mg for non‐Asians, because the plasma exposure is higher East Asians. A multicentre, double‐blind, randomised, placebo‐controlled, 8‐week, phase III study enrolled 155 chronic, previously treated . Dosage could be adjusted (25–75 mg/day) to maintain 50–250 × 10 9...
We, the Editors, Authors and Publisher of journal Artificial Cells, Nanomedicine, Biotechnology, have retracted following article:Tao Peng, Xiaoyan Liu, Jingtao Wang, Yu Zhenqiang Fu, Xingrong Ma, Junmin Li, Guifang Sun, Yangfei Ji, Jingjing Lu, Wencui Wan & Hong Lu (2019) Long noncoding RNA HAGLROS regulates apoptosis autophagy in Parkinson’s disease via regulating miR-100/ATG10 axis PI3K/Akt/mTOR pathway activation. 47:1, 2764–2774, DOI: 10.1080/21691401.2019.1636805Since publication,...
Multiple myeloma is a malignant plasma-cell disease, which highly dependent on the hypoxic bone marrow microenvironment. However, underlying mechanisms of hypoxia contributing to genesis are not fully understood. Here, we show that long non-coding RNA DARS-AS1 in directly upregulated by inducible factor (HIF)-1. Importantly, required for survival and tumorigenesis cells both vitro vivo. exerts its function binding RNA-binding motif protein 39 (RBM39), impedes interaction between RBM39 E3...
Abstract Philadelphia chromosome‐negative (Ph−) myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal disorders the bone marrow, and associated with high disease burden, reduced quality life (QOL), shortened survival. This multinational, multicenter, non‐interventional registry “MERGE” was initiated an objective to collect data on epidemiological indices classical Ph‐MPNs, existing treatment patterns, impact MPNs health‐related QOL in various countries/regions Asia,...
Abstract Background A growing body of evidence has demonstrated the vital roles circular RNAs (circRNAs) in cancer progression and drug resistance. We intended to explore mechanisms circ_ZFR paclitaxel (PTX) resistance non-small cell lung (NSCLC). Methods Two NSCLC lines A549 H460 were used this study. Quantitative real-time polymerase chain reaction (qRT-PCR) assay was conducted measure levels circ_ZFR, ZFR, miR-195-5p karyopherin subunit alpha 4 (KPNA4) mRNA. RNase R analyze characteristic...
Abstract Purpose: To investigate the efficacy and safety of novel orally active PI3Kδ inhibitor in relapsed and/or refractory patients with follicular lymphoma (FL) who had received at least two prior systemic treatments. Patients Methods: Histologically confirmed FL disease progression after receiving second-line or greater therapy were enrolled. Linperlisib was administered 80 mg every day, a 28-day cycle until intolerable toxicity occurred. The primary outcome for study objective response...