A5100405777- Cancer, Hypoxia, and Metabolism
- Endometriosis Research and Treatment
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Reproductive Biology and Fertility
- Neuropeptides and Animal Physiology
- Cancer-related molecular mechanisms research
- Cancer, Stress, Anesthesia, and Immune Response
- Cholesterol and Lipid Metabolism
- Immune Response and Inflammation
- Growth Hormone and Insulin-like Growth Factors
- Kruppel-like factors research
- NF-κB Signaling Pathways
- Reproductive System and Pregnancy
- Sirtuins and Resveratrol in Medicine
- Salivary Gland Disorders and Functions
- Nerve injury and regeneration
- Cytokine Signaling Pathways and Interactions
- Diet and metabolism studies
- Head and Neck Cancer Studies
- Erythrocyte Function and Pathophysiology
- RNA modifications and cancer
- interferon and immune responses
- Pharmaceutical Practices and Patient Outcomes
- Cellular Mechanics and Interactions
Shanghai Jiao Tong University
2015-2024
International Peace Maternity & Child Health Hospital
2019-2024
Xishuangbanna Tropical Botanical Garden
2023
Tongren Hospital
2020-2022
Zoucheng People's Hospital
2020
XinHua Hospital
2017
Shanghai First People's Hospital
2017
Shanghai Ninth People's Hospital
2006-2014
State Key Laboratory of Oncogene and Related Genes
2012
Shanghai Cancer Institute
2012
Abstract Background Nuclear factor-kappa B (NF-κB) signaling constitutes a key event in the multistep process of carcinogenesis, progression and treatment many cancer types. However, significance NF-κB pathway for complex tissue-specific aspects head neck progression, such as invasion metastasis, is less understood. Methods The expression p65 squamous cell carcinoma (SCCHN) clinical specimens by immunohistochemistry. role activity was determined western blot, reporter assay EMSA analysis...
An increasing number of studies have revealed that microRNA (miRNA) contributes to the pathogenesis autoimmune diseases. The objective this study is investigate miR-146a and miR-155 levels in peripheral mononuclear blood cells from patients with primary Sjögren's syndrome (pSS) who were not receiving medications examine correlations between these miRNA clinical features disease.Using real-time polymerase chain reaction analysis miRNAs, expression assessed 27 pSS 22 healthy controls,...
It has long been believed that most female mammalian species lose the ability to generate oocytes in postnatal ovaries. Recent evidence demonstrated isolation and culture of germline stem cells (FGSCs) from adult mice humans. However, process mechanisms FGSC differentiation vivo following transplantation have not yet studied. Here, we isolated characterized FGSCs a single EGFP-transgenic mouse, traced development behavior transplanted (F-TFs) vivo. Comparisons folliculogenesis between...
Abstract Background Cisplatin is widely used for chemotherapy of head and neck squamous cell carcinoma. However, details the molecular mechanism responsible cisplatin resistance are still unclear. The aim this study was to identify expression genes related in oral carcinoma cells. Methods A cisplatin-resistant line, Tca/cisplatin, established from a cisplatin-sensitive Tca8113, which derived moderately-differentiated tongue Global gene resistant line its sensitive parent analyzed using...
Background Recent advances have indicated a complex interplay between the autonomic nervous system and innate immune system. Targeting neural networks for treatment of sepsis is being developed as therapeutic strategy. Because electroacupuncture at select acupoints can modulate activities system, we tested hypothesis that specific could systemic inflammatory responses improve survival via its impact on in rat model sepsis. Methods Sprague-Dawley male rats received 45 min before 1, 2, or 4 h...
Background Cyclin D1 (CCND1) has been associated with chemotherapy resistance and poor prognosis. In this study, we tested the hypothesis that CCND1 expression determines response clinical outcomes in locally advanced head neck squamous cell carcinoma (HNSCC) patients treated neoadjuvant followed by surgery radiotherapy. Methodology Findings 224 HNSCC were either cisplatin-based radiotherapy (neoadjuvant group, n = 100) or (non-neoadjuvant 124). was assessed immunohistochemistry. levels...
// Jun Wang 1 , Ping Zhang 2 Jie Zhong Mingyue Tan Jifu Ge Le Tao Yakui Li Yemin Zhu Lifang Wu Jianxin Qiu and Xuemei Tong Department of Urology, Shanghai General Hospital, Jiao University School Medicine, Shanghai, China Biochemistry Molecular Cell Biology, Key Laboratory for Tumor Microenvironment Inflammation, Correspondence to: Tong, email: Qiu, Keywords : PFKP, aerobic glycolysis, proliferation, clear cell renal carcinoma Received September 06, 2015 Accepted March 14, 2016 Published 25,...
Stress alters immunological and neuroendocrinological functions. An increasing number of studies indicate that chronic stress can accelerate tumor growth, but its role in colorectal carcinoma (CRC) progression is not well understood. The aim this study to investigate the effects restraint (CRS) on CRC cell growth nude mice possible underlying mechanisms. In study, we showed CRS increased levels plasma catecholamines including epinephrine (E) norepinephrine (NE), stimulated cell-derived...
Physiological mechanical stretch in vivo helps to maintain the quiescent contractile differentiation of vascular smooth muscle cells (VSMCs), but underlying mechanisms are still unclear. Here, we investigated effects SIRT1 VSMC response cyclic stretch.Rat VSMCs were subjected 10%-1.25Hz-cyclic vitro using a FX-4000T system. The data indicated that expression markers, including α-actin, calponin and SM22α, was significantly enhanced compared static controls. FOXO3a increased by stretch, FOXO4...
Endowing the conduit with conductivity has been an effective way to stimulate nerve growth and functional recovery. Here, conducting polyaniline (PANi) was used construct a conductive guidance by coating on surface of microtubes inserted in three-dimensional zein study repairing efficacy peripheral injury. PANi nanoparticles size 20-30 nm were synthesized coated through layer-by-layer deposition. Then, conduits including without implanted into rats bridge 10-mm sciatic defect autograft as...
Abstract Inflammatory bowel disease (IBD) has a close association with transketolase (TKT) that links glycolysis and the pentose phosphate pathway (PPP). However, how TKT functions in intestinal epithelium remains to be elucidated. To address this question, we specifically delete epithelial cells (IECs). IEC TKT-deficient mice are growth retarded suffer from spontaneous colitis. ablation brings about striking alterations of intestine, including extensive mucosal erosion, aberrant tight...
Obesity has recently become a prevalent health threat worldwide. Although emerging evidence suggested strong link between the pentose phosphate pathway (PPP) and obesity, role of transketolase (TKT), an enzyme in nonoxidative branch PPP that connects glycolysis, remains obscure adipose tissues. In this study, we specifically deleted TKT mouse adipocytes found no obvious phenotype upon normal diet feeding. However, adipocyte abrogation attenuated high-fat diet–induced reduced hepatic...
The increased proliferation and migration of vascular smooth muscle cells (VSMCs) play important roles in pathophysiological remodeling arteries during hypertension pregnancy. However, the mechanisms involved this process remain unclear. We hypothesized that Neuropeptide Y (NPY), which is a potent mitogenic peptide, participates modulating VSMCs Using pregnant hypertensive rats, induced by intraperitoneal injection L-nitro-arginine methylester (L-NAME), plasma concentration NPY was detected....
Abstract Transcription factor carbohydrate responsive element binding protein (ChREBP) promotes glycolysis and lipogenesis in metabolic tissues cancer cells. ChREBP-α ChREBP-β, two isoforms of ChREBP transcribed from different promoters, are both transcriptionally induced by glucose. However, the mechanism which glucose increases mRNA levels remains unclear. Here we report that hepatocyte nuclear 4 alpha (HNF-4α) is a key transcription for glucose-induced ChREBP-β expression. Ectopic HNF-4α...
Objective The objective of this study was to investigate the potential role T oll‐like receptor 9‐dependent p38 MAPK signaling pathway in pathogenesis primary S jögren's syndrome (p SS ) NOD / L tj mouse, aiming identify an ideal target therapy model for human p . Methods mice were chosen as a 9 and p‐p38 double‐positive peripheral blood mononuclear cells ( PBMC s) 4‐, 5‐, 8‐, 10‐, 15‐week‐old mouse analyzed by flow cytometry. expressions submandibular gland SMG also examined...
Endometriosis is a common reproductive disorder in women, with global prevalence of 10‑15%. Long noncoding RNAs (lncRNAs) are critical to gene transcription, cell cycle modulation and immune response. The lncRNA metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) reportedly mediates autophagy endometrial stromal cells endometriosis. present study aimed evaluate the role mechanism MALAT1 granulosa (GCs) Consequently, expression was upregulated GCs obtained from patients...
Abstract The nuclear factor-κB (NF-κB) signaling pathway regulates specific immunological responses and controls a wide range of physiological processes. NF-κB inhibitor alpha (IKBA) is an inhibitory mediator in the cytoplasm that modulates translocation DNA binding activities proteins. However, whether upstream cascade canonical has roles independent IKBA-mediated transcriptional activation remains unclear. Herein we investigated function IKBA mature sperm which translational events do not...
Introduction The adverse effects of neuromuscular junction dysfunctions caused by immune checkpoint inhibitor (ICI) drugs have not been thoroughly assessed in the clinics. Objective To assess cancer patients with events ICI therapy searching Food and Drug Administration Adverse Event Reporting System (FAERS) database. Methods FAERS data from January 2004 to December 2020 were collected analyze association between connection dysfunction use. Disproportionate analysis Bayesian used quantify...