A5055781445- Oral microbiology and periodontitis research
- Endodontics and Root Canal Treatments
- Dental Health and Care Utilization
- Dental Radiography and Imaging
- Pediatric health and respiratory diseases
- Genomics, phytochemicals, and oxidative stress
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Oral Health Pathology and Treatment
- Prostate Cancer Treatment and Research
- Immune Response and Inflammation
- Extracellular vesicles in disease
- Cardiovascular Function and Risk Factors
- Linguistic Education and Pedagogy
- Circular RNAs in diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer-related Molecular Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Dialysis and Renal Disease Management
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Dental Erosion and Treatment
- Occupational and environmental lung diseases
First Affiliated Hospital of Xinjiang Medical University
2016-2025
Stomatology Hospital
2020-2025
Fudan University
2012-2025
Xinjiang Medical University
2016-2025
People's Hospital of Xinjiang Uygur Autonomous Region
2016-2025
Shenyang Agricultural University
2018-2025
North Dakota State University
2022-2024
Seventh People's Hospital of Shanghai
2024
Sichuan University
2021-2024
State Key Laboratory of Biotherapy
2024
Abstract Early detection and accurate monitoring of chronic kidney disease (CKD) could improve care retard progression to end-stage renal disease. Here, using untargeted metabolomics in 2155 participants including patients with stage 1–5 CKD healthy controls, we identify five metabolites, 5-methoxytryptophan (5-MTP), whose levels strongly correlate clinical markers 5-MTP decrease CKD, mouse kidneys after unilateral ureteral obstruction (UUO). Treatment ameliorates interstitial fibrosis,...
Intestinal ischemia/reperfusion (I/R) injury has high morbidity and mortality rates. Gut microbiota is a potential key factor affecting intestinal I/R injury. Populations exhibit different sensitivities to injury; however, whether this interpopulation difference related variation in gut unclear. Here, elucidate the interaction between microbiome injury, we performed 16S DNA sequencing on preoperative feces of C57BL/6 mice fecal transplantation (FMT) experiments germ-free mice. The transwell...
Introduction Acute lung injury (ALI) is a major cause of morbidity and mortality after intestinal ischaemia/reperfusion (I/R). The gut microbiota its metabolic byproducts act as important modulators the gut–lung axis. This study aimed to define role succinate, key metabolite, in I/R-induced ALI progression. Methods Gut mice subjected I/R were analysed using 16S rRNA gene sequencing. Succinate level alterations measured germ-free or conventional treated with antibiotics. Succinate-induced...
The prevalence of early childhood caries (ECC) varies with geographical region and population. Uygur people, one 55 officially recognized ethnic minorities in China, have a population 10,069,346. We performed preschool-based cross-sectional study 670 children from the southern Xinjiang, to investigate severity ECC identify factors related dental health condition this ranging age 3 5 years was invited using three-stage stratified sampling Kashgar, westernmost city China. "dmft" index used...
Scope Obesity is closely related to the imbalance of white adipose tissue storing excess calories, and brown dissipating energy produce heat in mammals. Recent studies revealed that acquisition characteristics by adipocytes, termed “browning,” may positively contribute cellular bioenergetics metabolism homeostasis. The goal was investigate putative effects natural antioxidant sulforaphane (1‐isothiocyanate‐4‐methyl‐sulfonyl butane; SFN) on browning adipocytes. Methods results 3T3‐L1 mature...
This study assessed the prevalence and severity of early childhood caries (ECC) identified socioeconomic behavioral correlates disease in preschool children living Xinjiang.For this cross-sectional survey, 1727 aged 3-5 years Xinjiang were randomly recruited using a three-stage cluster sampling procedure. The "dmft" index according to WHO 1997 criteria was used assess ECC severe (S-ECC). A questionnaire completed by caregivers. Variables included sociodemographic characteristics, dietary...
In chronic kidney disease (CKD), patients inevitably reach end-stage renal and require transplant. Evidence suggests that CKD is associated with metabolite disorders. However, the molecular pathways targeted by metabolites remain enigmatic. Here, we describe roles of 1-hydroxypyrene in mediating fibrosis.We analysed 5406 urine serum samples from Stage 1-5 using metabolomics, was identified validated longitudinal drug intervention cohorts as well 5/6 nephrectomised adenine-induced rats.We...
The recent emergence of the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) 9 system has attracted significant attention for its potential to improve traits agricultural importance. However, most applications in livestock species date have depended on aberrant DNA repair generate frameshifting indels. Whether this genomic engineering technique involving homology-dependent (HDR) can be used introduce defined point mutations been less explored....
Patients with ALI (acute lung injury)/ARDS respiratory distress syndrome) are often septic and poor prognosis, which leads to a high mortality rate of 25–40%.
Hypoxia-inducible factor-1α (HIF-1α) and its downstream factor, 19 kDa BCL-2 interacting protein 3 (BNIP3), promote cellular autophagy under hypoxic conditions. However, their roles in pulpitis are unclear. Therefore, the changes inflammatory response levels caused by hypoxia during were evaluated. Additionally, regulatory mechanism of HIF-1α/BNIP3 was explored.