A5075406821- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolism, Diabetes, and Cancer
- Connective Tissue Growth Factor Research
- Neurological Disease Mechanisms and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Blood donation and transfusion practices
- Pharmacological Effects of Natural Compounds
- Pancreatic function and diabetes
- Cardiac Ischemia and Reperfusion
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Blood transfusion and management
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related molecular mechanisms research
- Erythrocyte Function and Pathophysiology
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Intensive Care Unit Cognitive Disorders
- MicroRNA in disease regulation
- Cerebrovascular and genetic disorders
- Advanced Glycation End Products research
- Histone Deacetylase Inhibitors Research
- Medicinal plant effects and applications
Jilin Medical University
2013-2024
Southern Medical University
2016-2022
Nanfang Hospital
2016-2022
Jiangsu Province Blood Center
2015-2020
People’s Hospital of Rizhao
2019
Merck & Co., Inc., Rahway, NJ, USA (United States)
2009-2018
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2018
Ege University
2017
The First Affiliated Hospital, Sun Yat-sen University
2014
Sun Yat-sen University
2014
Remote ischemic preconditioning (RIPC) may confer the protection in critical organs. The authors hypothesized that limb RIPC would reduce lung injury patients undergoing pulmonary resection.In a randomized, prospective, parallel, controlled trial, 216 elective thoracic resection under one-lung ventilation with propofol-remifentanil anesthesia were randomized 1:1 to receive either or conventional (control). Three cycles of 5-min ischemia/5-min reperfusion induced by blood pressure cuff served...
The mortality of critically ill patients associated with intestinal ischemia/reperfusion remains very high, which results from multiorgan dysfunction or failure due to injury induced by ischemia/reperfusion. This study was carried out investigate whether can cause cerebral and concomitant memory dysfunction, explore the potential mechanisms.Prospective, controlled, randomized animal study.University research laboratory.Male, adult Sprague-Dawley rats (weighing 250-300 g).Intestinal...
Sepsis-induced cardiac dysfunction can lead to death in sepsis. In this case, we targeted explore detail the relative mechanism of microRNA (miR)-124-3p sepsis-induced myocardial injury via specific protein 1/histone deacetylase 4/hypoxia-inducing factor 1α (SP1/HDAC4/HIF-1α) axis. Septic rats were modeled by cecal ligation puncture while vitro septic cardiomyocyte H9C2 induced lipopolysaccharide (LPS). miR-124-3p/SP1/HDAC4/HIF-1α expression levels tissues and LPS-treated cells measured....
In the present study, novel preventive effects of repeated low-dose radiation exposure on diabetes-induced cardiac inflammation and damage were investigated. C57BL/6J mice given multiple low doses streptozotocin (STZ, 60 mg/kg × 6) to generate type 1 diabetes. A week after last STZ injection, hyperglycemic diagnosed treated with without whole-body (25 mGy X rays) once every 2 days for 2, 4, 8, 12 16 weeks. Diabetes caused significant increases in inflammation, shown by time-dependent mRNA...
Inflammation events have been found to aggravate brain injury and blood-brain barrier (BBB) damage following subarachnoid hemorrhage (SAH). This study probed the role mechanism of a novel circRNA, circARF3, in regulating BBB SAH rats hypoxia-induced vascular endothelial cell (VEC) vitro. Levels circARF3 miR-31-5p were monitored by RT-PCR. The expression inflammatory factors IL-1β TNF-α was verified ELISA. In vivo model constructed Sprague Dawley (SD) rats. integrity cerebral edema, as well...
Fructose consumption in humans and animals has been linked to enhanced de novo lipogenesis, dyslipidemia, insulin resistance. Hereditary deficiency of ketohexokinase (KHK), the first enzymatic step fructose metabolism, leads essential fructosuria humans, characterized by elevated levels blood urinary following ingestion but is otherwise clinically benign. To address whether KHK associated with altered glucose lipid a Khk knockout (KO) mouse line was generated characterized. NMR spectroscopic...
This letter provides the first pharmacological proof of principle that sst3 receptor mediates glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. To enable these studies, we identified selective antagonist (1R,3R)-3-(5-phenyl-1H-imidazol-2-yl)-1-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-β-carboline (5a), with improved ion channel selectivity and mouse pharmacokinetic properties as compared to previously described tetrahydro-β-carboline imidazole antagonists. We...
Tissue-type plasminogen activator (tPA) is characterized as an effective drug for early thrombolytic therapy in acute cerebral infarction (ACI). However, tPA will increase the risk of hemorrhage if it used beyond treatment time window. The study aims to explore effects neuroserpin (NSP) on window thrombolysis ACI and underlying mechanism. middle artery occlusion (MCAO) model was constructed rats, which were randomly divided into six groups: sham operation group, 1-hour + NSP intervention...
Background: His bundle pacing (HBP) results in rapid synchronous ventricular activation, but has been associated with long procedure times and compromised sensing performance. This study sought to reduce time radiation exposure, improve electrical performance through more accurate lead placement. Methods: Intracardiac echocardiography (ICE) was used guide ablation implantation at the bundle, right atrial appendage (RAA), apex (RVA), assess cardiac function. Custom bipolar screw‐in leads...
Background Although periodic blood shortages are widespread in major Chinese cities, approximately 1x105 U of whole discarded yearly because under-collection. To reduce the wastage acid citrate dextrose solution B (ACD-B) anticoagulated under-collected (UC-WB), this study was performed to elucidate effect extracellular pH and holding time on erythrocyte quality. Mannitol-adenine-phosphate (MAP) concentrates (UC-RBCs) were prepared with UC-WB assess safety efficacy component. Methods The...
Innovation is an important approach to boost economic development and social advances, innovative talents are the cornerstone of pharmaceutical industry. Conventional education not, however, tightly interconnected with current developments because training lacks practicality innovation. A deep integration industry–university–research (IUR) would be a significant solve this issue. In view this, School Pharmacy Jilin Medical University has thus integrated its own specialized characteristics...
Purpose: Carotid dissection is the most important cause of ischemic stroke in young adults.Ischemic rate up to 20% people under 50 years.Recently, patients years age who were admitted emergency department with complaints diagnosed carotid dissection.Methods: For this purpose, cranio-cervical CT angio images our clinic suspected artery and as ICA retrospectively reviewed.the characteristics normal undergoing angiography investigated using 3D anatomical programs, specifically course stylohyoid...
Background: We previously demonstrated that propofol had a protective effect on the intestine at risk after an ischemic injury in rat model. The current study tested hypothesis such beneficial effects, so far mainly seen laboratory, are reproducible humans.Methods: Seventy patients undergoing elective open infrarenal abdominal aortic aneurysm repair were randomized to receive general anesthesia with either or sevoflurane. General was induced 3 µg/kg fentanyl, 0.2 mg/kg cisatracurium, and...