A5101618681- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Hearing, Cochlea, Tinnitus, Genetics
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Ion Channels and Receptors
- Sustainable Supply Chain Management
- Nanoparticles: synthesis and applications
- Heme Oxygenase-1 and Carbon Monoxide
- Long-Term Effects of COVID-19
- Polysaccharides and Plant Cell Walls
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Sustainable Industrial Ecology
- Biomarkers in Disease Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Supply Chain Resilience and Risk Management
- Mesenchymal stem cell research
- Urban and Freight Transport Logistics
- Nerve Injury and Rehabilitation
- Energy and Environment Impacts
- RNA Research and Splicing
- Mechanical Circulatory Support Devices
- Environmental Impact and Sustainability
Southern Medical University
2016-2024
Nanfang Hospital
2004-2024
Shanghai National Accounting Institute
2023
Nanfang College Guangzhou
2021-2022
First Affiliated Hospital of Zhengzhou University
2022
Guangzhou Medical University
2017
Guangzhou Women and Children Medical Center
2017
Ocular Surface Center
2016
Epithelial-mesenchymal transition (EMT) process is considered as a key event in the activation of hepatic stellate cells (HSCs). Hedgehog (Hh) pathway known to be required for EMT process. Long non-coding RNAs (lncRNAs) have been reported involved wide range biological processes. Plasmacytoma variant translocation 1 (PVT1), novel lncRNA, often up-regulated various human cancers. However, role PVT1 liver fibrosis remains undefined. In this study, was increased fibrotic tissues and activated...
Atherosclerosis is a common pathological basis of cardiovascular disease, which remains the leading cause mortality. Long noncoding RNAs (lncRNAs) are newly studied non-protein-coding involved in gene regulation, but how lncRNAs exert regulatory effect on atherosclerosis unclear. In this study, we found that lncRNA HOXC cluster antisense RNA 1 (HOXC-AS1) and homeobox C6 (HOXC6) were downregulated carotid by performing microarray analysis. The results verified atherosclerotic plaques normal...
Carbon neutrality, or “net zero”, has become the impact assessment project of human on Earth, increasingly structured to examine implications, for environment and people, proposed actions consequences inaction. International local collaboration efforts have been made with aim achieving carbon neutrality “net-zero” emissions; thus, policies technological innovations developed. Such impact-oriented risk control amount carbon-neutral pathways. Although such pathways may diverge in terms energy,...
The Food and Drug Administration–approved drug sirolimus, which inhibits mechanistic target of rapamycin (mTOR), is the leading candidate for targeting aging in rodents humans. We previously demonstrated that sirolimus could treat ARHL mice. In this study, we further demonstrate protects mice against cocaine-induced hearing loss. However, using efficacy safety tests, discovered developed substantial loss when administered high doses sirolimus. Using pharmacological genetic interventions...
ABSTRACT Background: Sepsis-associated acute kidney injury (SA-AKI) is a common problem in critically ill patients and associated with high morbidity mortality. Early prediction of the survival hospitalized SA-AKI necessary, but reliable valid model still lacking. Methods: We conducted retrospective cohort analysis based on training 2,066 enrolled from Multiparameter Intelligent Monitoring Intensive Care Database III (MIMIC III) validation 102 treated at Nanfang Hospital Southern Medical...
Mitochondrial dynamics in alveolar macrophages (AMs) are associated with sepsis-induced acute lung injury (ALI). In this study, we aimed to investigate whether changes mitochondrial could alter the polarization of AMs ALI and explore regulatory mechanism by focusing on sirtuin (SIRT)3-induced optic atrophy protein 1 (OPA1) deacetylation.
Accumulated evidence shows that vanin-1 (VNN1) plays a key part in glucose metabolism. We explored the effect of VNN1 on cholesterol metabolism, inflammation, apoptosis vitro, and progression atherosclerotic plaques apoE<sup>−/−</sup> mice. Oxidized LDL (Ox-LDL) significantly induced expression through an ERK1/2/cyclooxygenase-2/PPARα signaling pathway. increased cellular content decreased apoAI HDL-cholesterol (HDL-C)-mediated efflux by 25.16% 23.13%, respectively, THP-1 macrophage-derived...
Objectives: Our ex vivo study was designed to determine the sequestration of teicoplanin, tigecycline, micafungin, meropenem, polymyxin B, caspofungin, cefoperazone sulbactam, and voriconazole in extracorporeal membrane oxygenation (ECMO) circuits. Methods: Simulated closed-loop ECMO circuits were prepared using 2 types blood-primed ECMO. After circulation stabilized, drugs injected into circuit. Blood samples collected at 2, 5, 15, 30 min, 1, 3, 6, 12, 24 h after injection. Drug...
Abstract Atherosclerotic cardiovascular disease is considered as the leading cause of mortality and morbidity worldwide. Accumulating evidence supports an important role for long noncoding RNA (lnc ) in pathogenesis atherosclerosis. Nevertheless, lnc atherosclerosis‐associated vascular dysfunction underlying mechanism remain elusive. Here, using microarray analysis, we identified a novel RP 11‐714G18.1 with significant reduced expression human advanced atherosclerotic plaque tissues. We...
Supply chain sustainability (SCS) has gone beyond the sustainability-performance approach, towards increasing adoption of sustainability-practice approach. The use digital technologies in this approach can enhance resilience and human rights, particularly context green twin transition post-COVID-19 pandemic. To enrich paper aims to produce a roadmapping taxonomy, based on knowledge mapping dataset collected late December 2022 from Web Science Core Collection. As map reveals dimensions...
Gathering data and communicating stories about corporate social responsibility (CSR), environmental, governance (ESG) activities have been increasingly essential for both organizations governments, especially when formal responses policies to climate change become central if not mandatory in many contexts. Such responsible contribution the broader ecological resilience response Covid-19 pandemic needs be substantial explicit. To formulate a research education agenda across relevant...
It is unclear whether patients with hypertension are more likely to be infected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than the general population and there a difference in severity of disease (COVID-19) pneumonia who have taken ACEI/ARB drugs compared those not.This observational study included data from all clinically confirmed COVID-19 admitted Hankou Hospital, Wuhan, China, between January 5 March 8, 2020. Data were extracted clinical laboratory records. Follow-up...
This brief research report focuses on the effects of artificial intelligence (AI) environment, by analyzing latest documents issued major standard organizations such as International Telecommunication Union (ITU) and Internet Society China (ISC). By outlining developments into a platform canvas for carbon neutrality management services, this identifies potential “AI environment” (i.e., material composition environmental impact AI itself) purposeful use smart applications to benefit...
Excessive superoxide radical production by mitochondria is one of the underlying causes noise‐induced damage to tissues in inner ear. Mitochondria are highly dynamic organelles that maintained opposing processes fusion and fission, events which alter mitochondrial morphology, biogenesis, energy metabolism. The HEI‐OC1 auditory cell line possesses a interconnected network structure under normal growth conditions as revealed immunolabeling for Tom20. Treatment with antimycin A increased...
Rationale The solute carrier 4A11 (SLC4A11) protein, a plasma membrane bound sodium‐borate co‐transporter, is expressed in many different organs including salivary glands, kidney, cornea and the inner ear where it functions to maintain ion homeostasis. Its functional importance underscored by causative role of SLC4A11 gene mutations several inherited diseases, all which are characterized some form sensorineural defect. Objective To compare expression with other members SLC4 family ear, eye...
Exosomes are nanosized lipid vesicles released from cells. They believed to contain proteins, lipids and nucleic acid cargos, capable of deliver their cargos recipient cells, which in turn alter the expression genes neighboring An increasing body evidence indicates that they play a pivotal role cell-to-cell communication, is hijacked during various physiological pathological conditions, such as myocardial damage, angiogenesis, cardiac remodeling atherogenesis plaque formation. Further...
A large number of studies suggest that network analysis can better explain the formation and contagion financial risks. However, it's controversial whether connection act as a booster or stabilizer for market volatility. This paper proves degree is an essential factor in determining its impact on It found actual industry-dimensional portfolios mismatch with optimal portfolio constructed based Markowitz theory, networks are over-connected by fund networks. Furthermore, it shows both...