A5059510719- Acute Kidney Injury Research
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Heme Oxygenase-1 and Carbon Monoxide
- Gastric Cancer Management and Outcomes
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Sirtuins and Resveratrol in Medicine
- Cardiac Ischemia and Reperfusion
- Advanced Glycation End Products research
- Gastrointestinal Tumor Research and Treatment
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Anesthesia and Sedative Agents
- Helicobacter pylori-related gastroenterology studies
- Biochemical effects in animals
- Eicosanoids and Hypertension Pharmacology
- Hydrogen's biological and therapeutic effects
- Pharmacological Receptor Mechanisms and Effects
- Birth, Development, and Health
- Sphingolipid Metabolism and Signaling
- Vitamin C and Antioxidants Research
- Esophageal Cancer Research and Treatment
- Adenosine and Purinergic Signaling
- Biochemical Acid Research Studies
Nanfang Hospital
2018-2024
Southern Medical University
2014-2024
Guiyang Medical University
2024
Affiliated Hospital of Guizhou Medical University
2024
Bridge University
2015
Our previous studies showed that silent mating-type information regulation 2 homologue-1 (SIRT1, a deacetylase) upregulation could attenuate sepsis-induced acute kidney injury (SAKI). Upregulated SIRT1 can deacetylate certain autophagy-related proteins (Beclin1, Atg5, Atg7 and LC3) in vitro. However, it remains unclear whether the beneficial effect of is related to autophagy induction underlying mechanism this also unknown. In present study, caecal ligation puncture (CLP)-induced mice, an...
Abstract The increase of lactate is an independent risk factor for patients with sepsis-induced acute kidney injury (SAKI). However, whether elevated directly promotes SAKI and its mechanism remain unclear. Here we revealed that downregulation the deacetylase Sirtuin 3 (SIRT3) mediated hyperacetylation inactivation pyruvate dehydrogenase E1 component subunit alpha (PDHA1), resulting in overproduction renal tubular epithelial cells. We then found incidence replacement therapy (RRT) septic...
AKI: acute kidney injury; ATP: adenosine triphosphate; BUN: blood urea nitrogen; CLP: cecal ligation and puncture; eGFR: estimated glomerular filtration rate; H&E: hematoxylin eosin staining; LCN2/NGAL: lipocalin 2; LPS: lipopolysaccharide; LTL: lotus tetragonolobus lectin; mKeima: mitochondria-targeted Keima; mtDNA: mitochondrial DNA; PAS: periodic acid - Schiff RTECs: renal tubular epithelial cells; SAKI: sepsis-induced Scr: serum creatinine; SIRT3: sirtuin 3; TFAM: transcription factor A,...
Recent studies have shown that autophagy upregulation can attenuate sepsis-induced acute kidney injury (SAKI). The tumor suppressor p53 has emerged as an regulator in various forms of (AKI). Our previous showed acetylation exacerbated hemorrhagic shock-induced AKI and lipopolysaccharide (LPS)-induced endothelial barrier dysfunction. However, the role p53-regulated SAKI not been examined requires clarification. In this study, we observed dynamic changes renal tubular epithelial cells (RTECs)...
Melatonin reportedly alleviates sepsis-induced multi-organ injury by inducing autophagy and activating class III deacetylase Sirtuin family members (SIRT1–7). However, whether melatonin attenuates small-intestine along with the precise underlying mechanism remain to be elucidated. To investigate this, we employed cecal ligation puncture (CLP)- or endotoxemia-induced sepsis mouse models confirmed that treatment significantly prolonged survival time of mice ameliorated multiple-organ...
Delayed colonic postpolypectomy bleeding is the commonest serious complication after polypectomy. This study aimed to utilize massive sampling data of polypectomy analyze risk factors for delayed bleeding.The endoscopic 5600 patients with 15553 polyps removed (2005 2013) were analyzed retrospectively through univariate analysis and multiple logistic regression evaluate bleeding.Delayed occurred in 99 (0.6%). The rates different methods including hot biopsy forcep, Argon Plasma Coagulation...
Mitochondrial dynamics in alveolar macrophages (AMs) are associated with sepsis-induced acute lung injury (ALI). In this study, we aimed to investigate whether changes mitochondrial could alter the polarization of AMs ALI and explore regulatory mechanism by focusing on sirtuin (SIRT)3-induced optic atrophy protein 1 (OPA1) deacetylation.
Sepsis-induced acute kidney injury (SAKI) poses a significant clinical challenge with high morbidity and mortality. Excessive mitochondrial fission has been identified as the central pathogenesis of sepsis-associated organ damage, which is also implicated in early stages SAKI. Sirtuin 5 (SIRT5) emerged regulator cellular function; however, its role regulation sepsis-induced excessive underlying mechanism remains unclear. In this study, SAKI was modeled mice through cecal ligation puncture,...
Abstract Sepsis-induced acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is characterized by widespread pulmonary inflammation and immune response, in which pro-inflammatory polarization of alveolar macrophages (AMs) plays an important role. Mitochondria are the key intracellular signaling platforms regulating cell responses. Moreover, accumulating evidence suggests that mitochondrial dynamics imbalanced sepsis severe ALI/ARDS. However, functional significance AMs septic...
Tissue biopsy is often not very accurate for the diagnosis of gastric epithelial neoplasia (GEN), and results differ notably from endoscopic resection (ER) in terms pathological diagnosis. The aims this study were to evaluate diagnostic performances biopsy, magnifying endoscopy with narrow-band imaging (ME-NBI), plus ME-NBI GEN. This retrospectively analyzed 101 cases diagnosed as GEN using ER samples. discrepancies between ER, well evaluated. Factors that contributed such analyzed....