A5101724966- Mitochondrial Function and Pathology
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Gut microbiota and health
- Cardiovascular Function and Risk Factors
- Escherichia coli research studies
- ATP Synthase and ATPases Research
- Hemodynamic Monitoring and Therapy
- FOXO transcription factor regulation
- Sepsis Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Craniofacial Disorders and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Diabetes and associated disorders
- Biochemical effects in animals
- Cynara cardunculus studies
- Berberine and alkaloids research
- Acute Kidney Injury Research
- Cardiac Fibrosis and Remodeling
- Pomegranate: compositions and health benefits
- Advanced Glycation End Products research
- Pain Mechanisms and Treatments
- Infant Nutrition and Health
- Cancer Mechanisms and Therapy
Air Force Medical University
2024
Third Affiliated Hospital of Southern Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Qilu Hospital of Shandong University
2023
Nanfang Hospital
2017-2023
Southern Medical University
2015-2023
University of South China
2023
State Key Laboratory for Innovation and Transformation of Luobing Theory
2023
Wuhan University
2022-2023
Shandong University
2023
Abstract The increase of lactate is an independent risk factor for patients with sepsis-induced acute kidney injury (SAKI). However, whether elevated directly promotes SAKI and its mechanism remain unclear. Here we revealed that downregulation the deacetylase Sirtuin 3 (SIRT3) mediated hyperacetylation inactivation pyruvate dehydrogenase E1 component subunit alpha (PDHA1), resulting in overproduction renal tubular epithelial cells. We then found incidence replacement therapy (RRT) septic...
AKI: acute kidney injury; ATP: adenosine triphosphate; BUN: blood urea nitrogen; CLP: cecal ligation and puncture; eGFR: estimated glomerular filtration rate; H&E: hematoxylin eosin staining; LCN2/NGAL: lipocalin 2; LPS: lipopolysaccharide; LTL: lotus tetragonolobus lectin; mKeima: mitochondria-targeted Keima; mtDNA: mitochondrial DNA; PAS: periodic acid - Schiff RTECs: renal tubular epithelial cells; SAKI: sepsis-induced Scr: serum creatinine; SIRT3: sirtuin 3; TFAM: transcription factor A,...
Cardiac fibrosis plays a key role in the progression of diabetic cardiomyopathy (DCM). Previous studies demonstrated cardioprotective effects natriuretic peptides. However, peptide receptor C (NPRC) on cardiac DCM remains unknown. Here, we observed that myocardial NPRC expression was increased mice and patients with DCM.
Acute kidney injury (AKI) induced by renal ischemia reperfusion (RIR) is typically observed in surgeries and a leading cause of failure. However, there still an unmet medical need currently terms clinical treatments. Herein, we report the effect Urolithin A (UA) mouse RIR model, wherein demonstrated its underlying mechanism both vitro vivo. The expression levels p62 Keap1 significantly decreased, while that nuclear Nrf2 increased hypoxia cell model after UA treatment. Furthermore, apoptosis...
Sepsis is a threatening health problem and characterized by microvascular dysfunction. In this study, we verified that LPS caused the downregulation of Sirt1 hyperpermeability endothelial cells. Inhibition with ex527 or siRNA displayed higher permeability, while activation SRT1720 reversed LPS-induced hyperpermeability, formation fiber stress, disruption VE-cadherin distribution. pulmonary vein cells isolated from wild-type mice, was attenuated upon LPS, preserved in receptor advanced...
Background: Hepatocellular carcinoma (HCC), as an aggressive cancer with a high mortality rate, needs high-efficiency and low-toxicity drug therapy. Natural products have great potential candidate lead compounds for the development of new HCC drugs. Crebanine is isoquinoline alkaloid derived from Stephania various pharmacological effects such anti-cancer. However, molecular mechanism underlying crebanine-induced liver cells apoptosis has not been reported. Here, we investigated effect...
Mucin2 (MUC2), an important regulatory factor in the immune system, plays role host defense system against bacterial translocation. Probiotics known to regulate MUC2 gene expression have been widely studied, but interactions among probiotic, pathogens, and mucin are still not fully understood. The aim of this study was investigate blocking effects probiotics on meningitic E. coli-induced pathogenicities. In study, live combined probiotic tablets containing living Bifidobacterium,...
Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus (DM). Ferroptosis an atypical form iron-dependent, modulated cell death that has been shown to occur in human umbilical vein endothelial cells (HUVECs). Leonurine (LEO) single active ingredient extracted from
Objective: This study examined the relationships between skeletal deformities and pharyngeal airway of patients with nonsyndromic unilateral cleft lip palate (UCLP). Design: Retrospective study. Setting: Orthodontics Oral Maxillofacial Surgery Departments in Affiliated Hospital Stomatology, Nanjing Medical University, China. Patients, Participants: The sample comprised 30 UCLP healthy controls. Each group has 23 males 7 females. Interventions: All cone-beam computed tomography images were...
<title>Abstract</title> Dental pulpitis, a highly prevalent condition associated with severe pain, often poses challenge for conventional analgesics, which exhibit limited efficacy in providing effective relief. Previous researches have focused primarily on the dental pulp nerve fibers, trigeminal ganglion, and medullary dorsal horn. Over past few years, GABAergic neurons been validated as important regulators of pain. However, central neural mechanisms, especially involving higher brain...
Graphical Abstract The timeline design of animal models.
OBJECTIVES Heart rate (HR) is a crucial health indicator and also one of the factors we need to pay explicit attention to. Body Mass Index (BMI) considered cofactor in heart-related issues like heart increment recovery. Thus study was conducted determine relationship between BMI METHODOLOGY 24 participants aged 17-20 were examined during elliptical machine training once week continuously for three months. Their regular resting change after workout recorded compared with BMI. RESULTS The HR...
Abstract Background: It is not clear whether pulmonary artery catheter (PAC) placement beneficial for critically ill patients with heart disease. This study aims to investigate the association of PAC use 28-day mortality in that population. Methods: The MIMIC-IV database was employed identify cardiac disease or without insertion. primary outcome mortality. Multivariate regression modeled examine between and outcomes. Additionally, we examined effect modification by surgeries. Propensity...