A5100714225- Gut microbiota and health
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Probiotics and Fermented Foods
- Genetic and phenotypic traits in livestock
- Infant Nutrition and Health
- Animal Genetics and Reproduction
- Sperm and Testicular Function
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Electrochemical sensors and biosensors
- Immune Response and Inflammation
- Cell death mechanisms and regulation
- Advanced Battery Materials and Technologies
- Advancements in Battery Materials
- Escherichia coli research studies
- Analytical Chemistry and Sensors
- Toxic Organic Pollutants Impact
- Plant nutrient uptake and metabolism
- Astronomy and Astrophysical Research
- Stellar, planetary, and galactic studies
- Bioinformatics and Genomic Networks
- melanin and skin pigmentation
Zhujiang Hospital
2022-2025
Southern Medical University
2015-2025
First Affiliated Hospital of Xinjiang Medical University
2025
Xinjiang Medical University
2025
Xinjiang Astronomical Observatory
2024
Anhui Agricultural University
2020-2024
Chinese Academy of Sciences
2012-2024
Animal Science Research Institute
2023-2024
Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences
2012-2024
Zhejiang A & F University
2024
Mutations of the gene Lps selectively impede lipopolysaccharide (LPS) signal transduction in C3H/HeJ and C57BL/10ScCr mice, rendering them resistant to endotoxin yet highly susceptible Gram-negative infection. The codominant d allele mice was shown correspond a missense mutation third exon Toll-like receptor-4 ( Tlr4 ), predicted replace proline with histidine at position 712 polypeptide chain. are homozygous for null . Thus, mammalian protein has been adapted primarily subserve recognition...
It has long been known that probiotics can be used to maintain intestinal homeostasis and treat a number of gastrointestinal disorders, but the underlying mechanism remained obscure. Recently, increasing evidence supports notion certain probiotic-derived components, such as bacteriocins, lipoteichoic acids, surface layer protein secreted protein, have similar protective role on barrier function live probiotics. These bioactive components named 'postbiotics' in most recent publications. We...
Background: Quercetin, a major flavonol, wildly exists in plantage, which has been reported to have an anti-apoptosis and anti-inflammation effects on vascular endothelial cells, but its underlying molecular mechanisms remain unclear. Objective: The aim of this study was investigate the how quercetin inhibits tumor necrosis factor alpha (TNF-α) induced human umbilical vein cells (HUVECs) apoptosis inflammation. Methods Results: HUVECs were preconditioned with for 18 hours, subsequently...
Protein lysine malonylation, a newly identified protein post-translational modification (PTM), has been proved to be evolutionarily conserved and is present in both eukaryotic prokaryotic cells. However, its potential roles associated with human diseases remain largely unknown. In the study, we observed an elevated malonylation screening of seven acylations liver tissues db/db mice, which typical model type 2 diabetes. We also detected ob/ob another then performed affinity enrichment coupled...
The pattern-recognition receptor NOD2 senses bacterial muropeptides to regulate host immunity and maintain homeostasis. Loss-of-function mutations in are associated with Crohn's disease (CD), but how the variations microbial factors influence signaling pathology is elusive. We demonstrate that Firmicutes peptidoglycan remodeling enzyme, DL-endopeptidase, increased ligand level gut impacted colitis outcomes. Metagenomic analyses of global cohorts (n = 857) revealed DL-endopeptidase gene...
An artificial enzymatic cascade system with high activity and stability is engineered based on Fe3O4–Au@mesoporous SiO2 (MS) microspheres, which possess both intrinsic glucose oxidase (GOx)- peroxidase-mimic activities.
Inflammatory bowel disease (IBD) is a chronic recurrent intestinal inflammatory with no effective treatment. It known that postbiotics have gained widely attention because of their outstanding advantages in health issues. In previous studies, we characterized novel Lactobacillus rhamnosus GG (LGG)-derived postbiotic, HM0539, significant protective effects against the murine colitis, but precise mechanism unclear yet. this study, hypothesized function HM0539 might be derived by modulation...
As a master regulator of the macroautophagy/autophagy-lysosomal pathway, TFEB (transcription factor EB) plays prominent role in regulating neurodegenerative diseases and cancer. The transcription activity is tightly controlled by phosphorylation dephosphorylation. Phosphorylated S211 (p-S211) can be recognized YWHA/14-3-3 proteins for cytoplasmic localization. Here, we characterized interactions between phosphorylated determined structures complex with p-S211-peptide. Although critical...
BackgroundSirtuin 5 (SIRT5) is a NAD+-dependent lysine deacylase. The SIRT5 deficiency mouse model shows that it dispensable for metabolic homeostasis under normal conditions. However, the biological role of and acylation in pathological states such as obesity type 2 diabetes (T2D) remains elusive.MethodsThe hepatic SIRT5-overexpressing ob/ob (ob/ob-SIRT5 OE) was established by CRISPR/Cas9 gene editing tool Protein malonylation succinylation sites were identified immunoprecipitation coupled...
Abstract High‐performance lithium‐ion batteries (LIBs) are required for the rising energy storage demand, while their development depends mainly on cathode materials. Vanadium‐based compounds considered to be promising due feasibility of multielectron reactions arising from rich valence states vanadium (+2 +5). Herein, first time electrochemical properties a vanadium‐based fluoroxide, β‐KVOF 3 , as LIBs, reported. After optimization, reversible capacity high 274 mAh g −1 stable 300 cycles...
Secreted proteins are one of the direct molecular mechanisms by which microbiota influence host, thus constituting a promising field for drug discovery. Here, through bioinformatics-guided screening secretome clinically established probiotics from Lactobacillus, we identify an uncharacterized secreted protein (named LPH here) that is shared most these probiotic strains (8/10) and demonstrate it protects female mice colitis in multiple models. Functional studies show bi-functional...
Beneficial bacteria remain largely unexplored. Lacking systematic methods, understanding probiotic community traits becomes challenging, leading to various conclusions about their effects among different publications. We developed language model-based metaProbiotics rapidly detect bins from metagenomes, demonstrating superior performance in simulated benchmark datasets. Testing on gut metagenomes probiotic-treated individuals, it revealed the probioticity of intervention strains-derived and...
A novel enzyme sensor based on CdSe quantum dots (QDs)/polycaprolactone (PCL) composite porous fibers has been prepared via a simple electrospinning method. We choose PCL, biocompatible polymer, as the host polymer for electrospun and prepare QDs sensing probes. Experiments demonstrate that are miscible chemically inert to PCL in solvent mixture containing N,N-dimethylformamide chloroform. Therefore, uniformly distributed within fibers, leading good preservation of their original...
Abstract The objective of this study was to determine whether Lactobacillus rhamnosus GG culture supernatant (LCS) has a preventive effect against gut-derived systemic neonatal Escherichia coli (E. ) K1 infection. effects were evaluated in human colonic carcinoma cell line Caco-2 and rat models. Our vitro results showed that LCS could block adhesion, invasion translocation E. monolayer via up-regulating mucin production maintaining intestinal integrity. In vivo experiments revealed...
Single cell-inductively coupled plasma-mass spectrometry (SC-ICP-MS) is an emerging technology. In this work, we have developed a novel SC-ICP-MS method to quantify metal ions in individual cells of toxic cyanobacterial species, Microcystis aeruginosa (M. aeruginosa), without complicated post-dosing sample preparation, and applied study the treatment effectiveness copper-based algaecides (cupric sulfate EarthTec®) on algae M. aeruginosa. The uses new intrinsic element magnesium determine...
Proteus mirabilis is commonly considered to be an opportunistic pathogen causing urinary tract infections (UTIs) in humans. However, some strains of P. were found associated with food poisoning outbreaks, the pathogenic mechanism still unclear. In our study, we described a novel strain C02011 isolated from patients' specimens China. order determine its gastrointestinal pathogenicity, experiments performed compare B02005 (isolated healthy people) and American Type Culture Collection (ATCC)...
Malus hupehensis, as an apple rootstock, is economically important tree species popular due to its excellent fruit yield and stress resistance. Nitrogen one of the critical limiting factors plant growth yield, so it crucial explore new methods improve nitrogen use efficiency. Melatonin dopamine, multifunctional metabolites, play numerous physiological roles in plants. We analyzed effects exogenous melatonin dopamine treatments on growth, root system architecture, absorption, metabolism M....