A5033322598- Inflammatory Bowel Disease
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Mycobacterium research and diagnosis
- IL-33, ST2, and ILC Pathways
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- Renal Transplantation Outcomes and Treatments
- Nutritional Studies and Diet
- Liver Diseases and Immunity
- Diagnosis and treatment of tuberculosis
- Celiac Disease Research and Management
- Autoimmune and Inflammatory Disorders
- Digestive system and related health
- Tuberculosis Research and Epidemiology
- T-cell and B-cell Immunology
- Gastrointestinal motility and disorders
- Immunodeficiency and Autoimmune Disorders
- Drug Transport and Resistance Mechanisms
- Eosinophilic Esophagitis
- Infant Nutrition and Health
The First Affiliated Hospital, Sun Yat-sen University
2007-2025
Sun Yat-sen University
2007-2025
University Medical Center Groningen
2019-2025
University of Groningen
2019-2025
Zhejiang Chinese Medical University
2025
Shanghai University of Engineering Science
2023
Institute of Precision Mechanics
2022
Donghua University
2016-2019
Institut thématique Génétique, génomique et bioinformatique
2019
Cancer Research And Biostatistics
2019
Objective Inflammatory bowel disease (IBD) is a multifactorial immune-mediated inflammatory of the intestine, comprising Crohn’s and ulcerative colitis. By characterising metabolites in faeces, combined with faecal metagenomics, host genetics clinical characteristics, we aimed to unravel metabolic alterations IBD. Design We measured 1684 different 8 short-chain branched-chain fatty acids stool samples 424 patients IBD 255 non-IBD controls. Regression analyses were used compare concentrations...
Disrupted host-microbe interactions at the mucosal level are key to pathophysiology of IBD. This study aimed comprehensively examine crosstalk between gene expression and microbiota in patients with To tissue-specific interactions, we perform transcriptomic (RNA-seq) microbial (16S-rRNA-seq) profiling 697 intestinal biopsies (645 derived from 335 IBD 52 16 non-IBD controls). Mucosal patterns mainly determined by tissue location inflammation, whereas composition shows a high degree individual...
Microbial dysbiosis, characterized by an imbalanced microbial community structure and function, has been linked to hypertension. While prior research primarily focused on differential abundances, our study highlights the role of non-differential microbes in We propose that contribute hypertension through their ecological interactions, as defined co-abundances (pairs exhibiting correlated abundance patterns). Using gut microbiome data from Guangdong Gut Microbiome Project, which includes 2355...
Renal transplantation is life-changing in many aspects. This includes changes to the gut microbiome likely due exposure immunosuppressive drugs and antibiotics. As a consequence, renal transplant recipients (RTRs) might suffer from intestinal dysbiosis. We aimed investigate of RTRs compare it with healthy controls identify determinants RTRs. Therefore, participating TransplantLines Biobank Cohort Study (NCT03272841) were included. analyzed using 16S rRNA sequencing compared composition...
Organ transplantation is a life-saving treatment for patients with end-stage disease, but survival rates after vary considerably. There now increasing evidence that the gut microbiome linked to of undergoing hematopoietic cell transplant, yet little known about role in solid organ transplantation. We analyzed 1370 fecal samples from 415 liver and 672 renal transplant recipients using shotgun metagenomic sequencing assess microbial taxonomy, metabolic pathways, antibiotic resistance genes,...
The pattern-recognition receptor NOD2 senses bacterial muropeptides to regulate host immunity and maintain homeostasis. Loss-of-function mutations in are associated with Crohn's disease (CD), but how the variations microbial factors influence signaling pathology is elusive. We demonstrate that Firmicutes peptidoglycan remodeling enzyme, DL-endopeptidase, increased ligand level gut impacted colitis outcomes. Metagenomic analyses of global cohorts (n = 857) revealed DL-endopeptidase gene...
BackgroundMitochondrial dysfunction has been linked to the development of inflammatory bowel disease (IBD), but genetic pathophysiology was not fully elucidated. We employed Mendelian randomization and colocalization analyses investigate associations between mitochondrial-related genes IBD via integrating multi-omics.MethodsSummary-level data mitochondrial gene methylation, expression protein abundance levels were obtained from corresponding quantitative trait loci studies, respectively....
Pro-inflammatory diet interacting with gut microbiome might trigger for Crohn's disease (CD). We aimed to investigate the relationship between dietary inflammatory potential and microflora/metabolites change their link CD.The was assessed using a index (DII) based on Food Frequency Questionnaire from 150 new-onset CD patients 285 healthy controls (HCs). selected 41 89 HCs who had not received medication metagenomic targeted metabolomic sequencing profile microbial composition as well fecal...
Objective Both the gut microbiome and host genetics are known to play significant roles in pathogenesis of IBD. However, interaction between these two factors its implications aetiology IBD remain underexplored. Here, we report on influence Design To evaluate impact microbiota patients with IBD, combined whole exome sequencing genome shotgun 1464 faecal samples from 525 939 population-based controls. We followed a four-step analysis: (1) exome-wide microbial quantitative trait loci (mbQTL)...
The influence of dairy on the gut microbiome has not been studied extensively. We performed a randomized cross-over study to analyze effect high intake microbiome. Subjects were randomly assigned high-dairy diet (HDD) (5-6 portions per day) and low-dairy (LDD) (≤1 portion for 6 weeks with washout period 4 in between both diets. was assessed using 16S rRNA gene sequencing. Compositionality functionality Quantitative Insights Into Microbial Ecology (QIIME) Phylogenetic Investigation...
Abstract More than 240 genetic risk loci have been associated with inflammatory bowel disease (IBD), but little is known about how they contribute to development in involved tissue. Here, we hypothesized that host variation affects gene expression an inflammation-dependent way, and investigated 299 snap-frozen intestinal biopsies from inflamed non-inflamed mucosa 171 IBD patients. RNA-sequencing was performed, genotypes were determined using whole exome sequencing genome wide genotyping. In...
The colonization of microbes in the gut is key to establishing a healthy host-microbiome symbiosis for newborns. We longitudinally profiled microbiome model consisting 36 neonatal oxen from birth up 2 months postpartum and carried out microbial transplantation reshape their microbiome. Genomic reconstruction deeply sequenced fecal samples resulted total 3931 metagenomic-assembled genomes 472 representative species, which 184 were identified as new species when compared with existing...
Abstract Cardiometabolic health is closely linked to diet. Both specific food choices and dietary indices are commonly used guide cardiometabolic protection strategies. However, the balance between foods may also significantly impact health. Here, we explore imbalance in long-term intake quantify pairing patterns (FPs), providing insights beyond conventional single-food frequencies. Using data from our GGMP (n = 6,994) NHANES 7,350) cohorts, observed that independent of single frequency...
ABSTRACT Aim Masticatory dysfunction due to tooth loss is a potentially modifiable risk for mortality, but the pathway behind that remains be investigated. This prospective study aimed examine role of diet and ageing in associations between chewing capacity long‐term mortality. Methods Data were obtained from participants (aged ≥ 20) National Health Nutritional Survey (NHANES 1999–2010, n = 22,900). The mortality follow‐up ended on 31 December 2019. Chewing was determined by number...
Abstract Background Current consensus guidelines recommend the early initiation of biologic therapies for managing Crohn’s disease (CD). Among first-line options, infliximab (IFX) and ustekinumab (UST) have shown significant efficacy. However, therapeutic responses vary, necessitating reliable biomarkers personalized treatment strategies. Methods This retrospective study included bio-naive CD patients treated with IFX or UST at First Affiliated Hospital Sun Yat-sen University between May...