A5091455685- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Microscopic Colitis
- Gold and Silver Nanoparticles Synthesis and Applications
- Methane Hydrates and Related Phenomena
- Gut microbiota and health
- Fungal Biology and Applications
- Carbon Dioxide Capture Technologies
- TiO2 Photocatalysis and Solar Cells
- Microbial Natural Products and Biosynthesis
- Plant biochemistry and biosynthesis
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Cardiomyopathy and Myosin Studies
- Plant and fungal interactions
- Nanocluster Synthesis and Applications
- Hydrocarbon exploration and reservoir analysis
- Industrial Gas Emission Control
- Quantum Dots Synthesis And Properties
- Geology and Paleoclimatology Research
- Copper-based nanomaterials and applications
- Advanced Photocatalysis Techniques
- Galectins and Cancer Biology
- Graphene and Nanomaterials Applications
- Geological Studies and Exploration
Southern Medical University
2015-2025
Nanfang Hospital
2015-2025
Zhejiang Pharmaceutical College
2018-2024
Southwest University
2017-2024
Second Hospital of Shandong University
2024
Karamay Central Hospital of Xinjiang
2023-2024
Beijing Normal University
2024
Research Institute of Petroleum Exploration and Development
2023
Xinyang Normal University
2013-2023
Shenzhen University
2023
Abstract Impaired epithelial regeneration is a crucial pathophysiological feature of ulcerative colitis (UC). Yes-associated protein (YAP1) appears to control cell proliferation and differentiation. In this study, we sought identify the roles YAP in intestinal (IEC) self-renewal, tumorigenesis. We first observed that was significantly reduced 62.5% (45/72) human UC tissues it dramatically enhanced during murine model. Using lentiviral infection, established YAP-overexpression (YAP WT ) mouse...
Background: Long noncoding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides in length. They drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, RNA and protein. Recent studies have identified numerous lncRNAs active colorectal (CRC). The lncRNA small nucleolar host gene 6 (SNHG6) has been reported to an oncogenic role multiple cancers. However, the biological mechanism of SNHG6 tumorigenesis CRC not...
Catalytic degradation of organic dye molecules has attracted extensive attention due to their high toxicity water resources. In this paper, we propose a novel method for the fabrication uniform silver-coated ZnO nanowire arrays. The typical molecule rhodamine 6G (R6G), as an example, is investigated in presence as-prepared experimental results show that such composite nanostructures exhibit catalytic activity, and reaction follows pseudo-first-order kinetics. Furthermore, these arrays are...
Clostridium difficile is currently the leading cause of nosocomial infection. Antibiotics remain first-line therapy for C. difficile-associated diseases (CDAD), despite risks resistance promotion and further gut microbiota perturbation. Notably, abundance Bacteroides fragilis was reported to be significantly decreased in CDAD patients. This study aimed clarify prophylactic effects B. strain ZY-312 a mouse model infection (CDI). The CDI successfully created using VPI 10463 spores, as...
Dye wastewater is one of the most important problems to be faced and solved in treatment. However, treatment cannot single simple adsorption due complexity dye species. In this work, we prepared novel composite fiber adsorbent materials consisting ε-polycaprolactone (PCL) beta-cyclodextrin-based polymer (PCD) by electrospinning. The morphological spectral characterization demonstrated successful preparation a series fibers with different mass ratios. obtained have remarkable selective for MB...
The pattern-recognition receptor NOD2 senses bacterial muropeptides to regulate host immunity and maintain homeostasis. Loss-of-function mutations in are associated with Crohn's disease (CD), but how the variations microbial factors influence signaling pathology is elusive. We demonstrate that Firmicutes peptidoglycan remodeling enzyme, DL-endopeptidase, increased ligand level gut impacted colitis outcomes. Metagenomic analyses of global cohorts (n = 857) revealed DL-endopeptidase gene...
Hydroxyl-functionalized graphene (G–OH) was efficiently produced from exfoliation of graphite powder by ball milling the presence potassium hydroxide (KOH). While nanoscale sheets were confirmed various characterization techniques, including atomic force microscopy (AFM), scanning electron (SEM), transmission (TEM), and UV-vis spectroscopy, formation hydroxyl groups in G–OH revealed Fourier transform infrared (FTIR), Nuclear Magnetic Resonance analysis (NMR), Raman X-ray photoelectron...
Noble-metal nanomaterials were widely investigated as theranostic systems for surface enhanced Raman scattering (SERS) imaging, and also photothermal therapy (PTT) of cancers. However, it was still a major challenge to explore multifunctional nanoprobes with high performance, stability, low toxicity. In this work, reporter (DTTC)-coupled Agcore@Aushell nanostars (Ag@Au-DTTC) synthesized in vivo improved SERS imaging near-infrared (NIR)-triggered PTT breast By the two-step coupling DTTC,...
Zr/Mg oxide-PS was designed to extend the applicability of nanostructured metal oxide bearing composites Cu(<sc>ii</sc>) removal in acidic wastewaters.
Abstract Sustained anti-angiogenesis therapy increases the level of tumor hypoxia, leading to increased expression HIF-1a, thereby contributing resistance in hepatocellular carcinoma (HCC). Here, we report that phenazine biosynthesis-like domain-containing protein (PBLD) inhibits hypoxia-induced angiogenesis via ERK/HIF-1a/VEGF axis HCC cells. Bioinformatic analysis TCGA database and clinical samples validation also identify a negative correlation between PBLD angiogenesis-related genes...
Abstract Raman spectroscopy is a very sensitive tool for probing semiconductor nanocrystals. The underlying mechanism behind the size-dependent shifts still quite controversial. Here we offer new theoretical method quantum confinement effects on spectra of We propose that shift in nanocrystals can result from two overlapping effects: effect and surface shift. extracted an extended Kubo formula, determined via first principles calculations. Fairly good prediction be obtained without use any...
Metagenomic analyses indicate that streptococcus gallolyticus is enriched at carcinoma in colitis associated colorectal cancer compared with sporadic cancer. But the particular mechanism of Inflammatory Bowel Disease malignant progression remains undefined yet. We aim to explore biological carcinogenesis efficacy and its potential azoxymethane dextran sodium sulphate-induced mice. Oral pretreatment was adopted evaluate detrimental effect. The colorectums experimental C57BL/6 mice were...
Intestinal barrier function defects and dysregulation of intestinal immune responses are two key contributory factors in the pathogenesis ulcerative colitis (UC). Phenazine biosynthesis-like domain-containing protein (PBLD) was recently identified as a tumor suppressor gastric cancer, hepatocellular carcinoma, breast cancer; however, its role UC remains unclear. Therefore, we analyzed colonic tissue samples from patients with constructed specific epithelial PBLD-deficient (PBLDIEC-/-) mice...
Probiotics play critical roles in relieving inflammatory bowel disease (IBD). However, the underlying mechanism of Bacteroides fragilis strain ZY-312 (B. fragilis) for colonic mucosa regeneration IBD remains unclear.The weight loss, activity index (DAI), colon length, and histopathology-associated (HAI) were evaluated therapeutic effects B. a DSS-induced colitis mouse model. Colonic proliferation apoptosis level, mucus density detected by histological stain. Gut microbiota was sequenced...
<title>Abstract</title> <bold>Introduction</bold>: IR (IR) is a common complication in patients with colorectal cancer (CRC) after radiotherapy. Currently, the search for effective treatments has become an urgent priority. Nicotinamide riboside (NR), precursor of vitamin B3 derivative and NAD (+), was enriched treatment commensal <italic>Bacteroides fragilis</italic>, suggesting that NR may perform protective role. However, specific role remains unclear. In this study, we investigated...
Wolfiporia cocos Ryvarden et Gilbertson is a saprophytic fungus in the Basidiomycetes. Its dried sclerotium widely used as traditional crude drug East Asia. Especially China, regarded silver of Chinese drugs, not only for its white color, but also medicinal value. Furthermore, triterpenoids from W. are main active compounds with antitumor and anti-inflammatory activity. Biosynthesis has rarely been researched. In this study, de novo sequencing mycelia sclerotia were carried out by Illumina...
Early diagnosis and treatment of ulcerative colitis (UC) is clinically challenging. To overcome this problem, we explored the interrelated multiplex signaling pathway to identify molecular signatures in UC by using integrated strategy proteomics. Intestinal mucosa 12 cases normal controls underwent comparative proteomic analysis. A total 26 unique differential proteins were identified, including up-regulated 14 down-regulated group. protein cluster, consisting 11 involved p38...
Background . Allicin has anti‐inflammatory, antioxidative and proapoptotic properties. Aims To evaluate the effects investigate mechanism of allicin on trinitrobenzenesulfonic acid‐induced colitis, specifically with mesalazine or sulfasalazine. Methods 80 rats were divided equally into 8 groups: control; acid; prevention; allicin; mesalazine; sulfasalazine; + sulfasalazine, allicin. Systemic colonic inflammation parameters analysed. In addition, protein culture medium Caco‐2 cells treated...
Huperzine A (HupA) is a plant alkaloid that of great interest as therapeutic candidate for the treatment Alzheimer's disease. However, current production HupA from plants in large quantity unsustainable because resource scarce and content extremely low. Surprisingly, this compound was recently found to be produced by various endophytic fungi, which are much more controllable than due simpler genetics ease manipulation. it might innate properties symbiosis, chemical endophytes has not yet...