A5101845143- Monoclonal and Polyclonal Antibodies Research
- Circadian rhythm and melatonin
- Plant-based Medicinal Research
- Sleep and Work-Related Fatigue
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Radiopharmaceutical Chemistry and Applications
- Image and Video Quality Assessment
- Traditional Chinese Medicine Studies
- Hippo pathway signaling and YAP/TAZ
- Pancreatitis Pathology and Treatment
- Neurofibromatosis and Schwannoma Cases
- HER2/EGFR in Cancer Research
- Esophageal and GI Pathology
- Glycosylation and Glycoproteins Research
- Multimedia Communication and Technology
- Video Coding and Compression Technologies
- Diet and metabolism studies
- Atherosclerosis and Cardiovascular Diseases
- Digital Transformation in Industry
- Acupuncture Treatment Research Studies
- Sleep and related disorders
- Helicobacter pylori-related gastroenterology studies
- Spaceflight effects on biology
- Inflammasome and immune disorders
Southern Medical University
2024-2025
Nanjing Drum Tower Hospital
2024
Nanfang Hospital
2024
Harvard University
2018-2023
Sun Yat-sen University
2018-2023
Chinese University of Hong Kong
2023
University of Hong Kong
2023
West China Medical Center of Sichuan University
2023
The First People's Hospital of Changzhou
2022
Soochow University
2016-2022
Abstract Purpose: We generated a humanized antibody, HuLuc63, which specifically targets CS1 (CCND3 subset 1, CRACC, and SLAMF7), cell surface glycoprotein not previously associated with multiple myeloma. To explore the therapeutic potential of HuLuc63 in myeloma, we examined detail expression profile CS1, binding properties to normal malignant cells, antimyeloma activity preclinical models. Experimental Design: was analyzed by gene profiling immunohistochemistry myeloma samples numerous...
Bispecific antibodies engineered to both bind the primate transferrin receptor and inhibit β-secretase are taken up by nonhuman brain reduce β-amyloid.
Bispecific antibodies using the transferrin receptor (TfR) have shown promise for boosting antibody uptake in brain. Nevertheless, there are limited data on therapeutic properties including safety liabilities that will enable successful development of TfR-based therapeutics. We evaluate TfR/BACE1 bispecific variants mouse and show reducing TfR binding affinity improves not only brain but also peripheral exposure profile these antibodies. identify seek to address targeting with antibodies,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFixed-bed photocatalysts for solar decontamination of waterYin. Zhang, John C. Crittenden, David W. Hand, and L. PerramCite this: Environ. Sci. Technol. 1994, 28, 3, 435–442Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/es00052a015https://doi.org/10.1021/es00052a015research-articleACS PublicationsRequest reuse permissionsArticle...
Optimizing the in vivo stability of positron emission tomography (PET) tracers is critical importance to cancer diagnosis. In case 64Cu-labeled monoclonal antibodies (mAb), behavior and biodistribution critically dependent on performance bifunctional chelator used conjugate mAb radiolabel. This study compared characteristics TRC105 (a chimeric that binds both human murine CD105), through two commonly chelators: 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA)...
<title>Abstract</title> <bold>Introduction</bold>: IR (IR) is a common complication in patients with colorectal cancer (CRC) after radiotherapy. Currently, the search for effective treatments has become an urgent priority. Nicotinamide riboside (NR), precursor of vitamin B3 derivative and NAD (+), was enriched treatment commensal <italic>Bacteroides fragilis</italic>, suggesting that NR may perform protective role. However, specific role remains unclear. In this study, we investigated...
Abstract Tumor metastasis represents the main causes of cancer-related death. Our recent study showed that chemokine CCL18 secreted from tumor-associated macrophages regulates breast tumor metastasis, but underlying mechanisms remain less clear. Here, we show ARF6 GTPase-activating protein ACAP4 CCL18-elicited cancer cell migration via acetyltransferase PCAF-mediated acetylation. stimulation elicited and invasion PCAF-dependent physically interacts with PCAF is a cognate substrate during...
Natural autoantibodies have been implicated to play a key role in the pathogenesis of coronary heart disease (CHD) because they augment autoimmune activation. The aim this study was identify novel specific CHD, and analyze relationship between their levels CHD risk indicators.First, clinical data sera from patients were collected. Then, one protein microarray containing 37 proteins that represent candidate autoantigens developed. arrays used profile randomly selected 35 samples (20 patients,...
The digestive function of the stomach depends on acidification gastric lumen. Acid secretion into lumen is triggered by activation a cAMP-dependent protein kinase (PKA) cascade, which ultimately results in insertion H,K-ATPases apical plasma membranes parietal cells. A coupling ezrin whose phosphorylation at Ser-66 PKA required for cell activation. However, little known regarding molecular mechanism(s) operates acid secretion. Here we show that induces conformational change enables its...
The digestive function of the stomach depends on acidification gastric lumen. Acid secretion into lumen is triggered by activation PKA cascade, which ultimately results in insertion H,K-ATPases apical plasma membranes parietal cells. A coupling protein ezrin, whose phosphorylation at Ser-66 required for cell activation. However, little known regarding molecular mechanism(s) this signaling pathway operates acid secretion. Here we show that cooperates with MST4 to orchestrate...
Digestion in the stomach depends on acidification of lumen. Histamine-elicited acid secretion is triggered by activation PKA cascade, which ultimately results insertion gastric H,K-ATPases into apical plasma membranes parietal cells. Our recent study revealed functional role PKA–MST4–ezrin signaling axis histamine-elicited secretion. However, it remains uncharacterized how operates Here we show that MST4 phosphorylates ACAP4, an ARF6 GTPase-activating protein, at Thr545. Histamine...
Background. Traditional Chinese medicine (TCM) has long been used to treat chronic atrophic gastritis (CAG). The aim of the present study was evaluate TCM syndrome characteristics CAG and its core pathogenesis so as promote optimization treatment strategies. Methods. This based on a participant survey conducted in 4 hospitals China. Patients diagnosed with were recruited by simple random sampling. Exploratory factor analysis (EFA) extraction. Results. Common factors extracted assigned six...
The emerging of third generation mobile system (3G) makes conversational video transmission in wireless environment possible, and the latest 3GPP/3GPP2 standards suggest 3G terminals support H.264/AVC. Due to high bit error rate environment, resilience schemes are necessary for terminals. Moreover, according 3GPP/3GPP2, only part tools This paper lists various analyzes their usability at same time, some proposed. Performances these tested using offline common test conditions. Experiments...
Background . Real world evidence is important for informing healthcare practice and developing medical products has gained broad interest in healthcare. Compound Kushen Injection (CKI) been widely applied into treatment of colon carcinoma (CC) China. Postapproval drug assessment related retrospective studies using electrical record (EMR) collected from hospital information system (HIS) one the most categories real‐world study (RWS). Based on HIS EMR, interrelationships combined medication...
Objectives: Poststroke cognitive impairment (PSCI) has constituted a heavy public health burden worldwide. Traditional Chinese Medicine (TCM) been widely used in treating PSCI. This study aimed at validating the TCM syndrome patterns of PSCI by using data mining methods. The findings will shed light on pathogenesis theory PSCI, and thus provide translation for optimization syndrome-targeted treatment strategies Design: is registry study-based participant survey conducted 14 medical centers...
The emergence of third generation mobile system (3G) makes video transmission in wireless environment possible, and the latest 3GPP/3GPP2 standards require 3G terminals support H.264/AVC. Due to high packet loss rate envi- ronment, error resilience for is necessary. Moreover, because hardware restrictions, only part H.264/AVC tool. This paper analyzes various tools their functions, presents 2 strategies streaming services conversational services. Performances proposed were tested using...
The use of self-expanding metallic stents (SEMS) is the current treatment choice for malignant gastrointestinal obstructions. A paclitaxel-eluting SEMS (PEMS) may have an antitumor effect on esophageal tissue. PEMS with 10% paclitaxel or conventional were inserted into lower esophagus rabbits. Following insertion 1, 2, 4 and 6 weeks, rabbits sacrificed status stent was examined, as well any macroscopic microscopic mucosal changes in All survived until death without complications. No...