A5100712397- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Genomics and Chromatin Dynamics
- Gut microbiota and health
- Microbial Metabolic Engineering and Bioproduction
- Cancer survivorship and care
- Analytical Chemistry and Chromatography
- Phytochemical compounds biological activities
- Natural Compounds in Disease Treatment
- Rheumatoid Arthritis Research and Therapies
- Traditional Chinese Medicine Studies
- Chromatography in Natural Products
- Gene expression and cancer classification
- Medicinal Plant Pharmacodynamics Research
- Plant biochemistry and biosynthesis
- Bioinformatics and Genomic Networks
- Glaucoma and retinal disorders
- Food Quality and Safety Studies
- Agronomic Practices and Intercropping Systems
- Microtubule and mitosis dynamics
- Microbial Natural Products and Biosynthesis
China Pharmaceutical University
2016-2025
Hebei General Hospital
2023-2025
Baoding People's Hospital
2020-2025
Hebei Medical University
2023-2025
Fujian Medical University
2018-2025
Union Hospital
2024-2025
Fujian Institute of Microbiology
2024-2025
Xiamen University
2005-2025
Nanjing Tech University
2025
Hubei University of Arts and Science
2023-2024
The phytohormone auxin plays critical roles in regulating myriads of plant growth and developmental processes. Microbe infection can disturb signaling resulting defects these processes, but the underlying mechanisms are poorly understood. Auxin begins with perception by a transient co-receptor complex consisting an F-box transport inhibitor response 1/auxin (TIR1/AFB) protein auxin/indole-3-acetic acid (Aux/IAA) protein. binding to triggers ubiquitination 26S proteasome degradation Aux/IAA...
Abstract Baker’s yeast Saccharomyces cerevisiae is an attractive cell factory for production of chemicals and biofuels. Many different products have been produced in this by reconstruction heterologous biosynthetic pathways; however, endogenous metabolism itself involves many metabolites industrial interest, de-regulation pathways to ensure efficient carbon channelling such therefore high interest. Furthermore, these may serve as precursors the biosynthesis complex natural products, hence...
Clematichinenoside AR (C-AR) is a triterpene saponin isolated from the root of Clematis manshurica Rupr., which herbal medicine used in traditional Chinese for treatment arthritis. C-AR exerts anti-inflammatory and immunosuppressive properties, but little known about its action suppression fibroblast activation. Low oxygen tension TGF-β1 induction synovium contribute to fibrosis arthrits. This study was designed investigate effect clematichinenoside on synovial aspects hypoxic HIF-1α...
Aims: Corosolic acid (CRA) is a natural triterpenoid with antioxidative activity. This study was designed to elucidate the mechanism through which CRA protected vessel endothelial homeostasis by combating oxidative stress. Results: In cells, induced dynamin-related protein 1 (Drp1) phosphorylation at Ser637 and thus inhibited mitochondrial fission in response It promoted AMP-activated kinase (AMPK) activity an LKB1-dependent manner, silencing AMPK abrogated its inhibitory effect on Drp1...
Stress has been proven to modulate an individual's immune system through the release of pituitary and adrenal hormones such as catecholamines, growth hormone glucocorticoids. These signal molecules can significantly alter host make it susceptible viral infection. In this study, we investigate whether epigoitrin, a natural alkaloid from Isatis indigotica, provide protection against influenza infection by reducing host's susceptibility virus under stress it's underlying mechanism. To prove it,...
Abstract The tea green leafhopper, Empoasca vitis Göthe, is one of the most serious insect pests plantations in mainland China. Over past decades, this pest has been controlled mainly by spraying pesticides. Insecticide applications not only have become less effective controlling damage, but even more seriously, caused high levels toxic residues teas, which ultimately threatens human health. Therefore, we should seek a safer biological control approach. In present study, key components shoot...
Chromosome segregation in mitosis is orchestrated by the dynamic interactions between kinetochore and spindle microtubules. Our recent study shows that mitotic motor CENP-E cooperates with SKAP to orchestrate an accurate chromosome movement mitosis. However, it remains elusive how core microtubule binding activity KMN (KNL1-MIS12-NDC80) regulates plus-end dynamics. Here, we identify a novel interaction MIS13 orchestrates physically interacts specifies localization of SKAP. Suppression small...
Glomerular endothelial cells (GECs) are pivotal in developing glomerular sclerosis disorders. The advancement of focal segmental glomerulosclerosis (FSGS) is intimately tied to disruptions lipid metabolism. Sphingosine-1-phosphate (S1P), a molecule transported by high-density lipoproteins (HDL), exhibits protective effects on vascular upregulating phosphorylated nitric oxide synthase (p-eNOS) and enhancing (NO) production. Nevertheless, the abundance S1P within HDL individuals with FSGS...
Enhancer clusters, pivotal in mammalian development and diseases, can organize as enhancer networks to control cell identity disease genes; however, the underlying mechanism remains largely unexplored. Here, we introduce eNet 2.0, a comprehensive tool for analysis during diseases based on single-cell chromatin accessibility data. 2.0 extends our previous work 1.0 by adding network topology, comparison dynamics analyses its construction function. We reveal modularly organized networks, where...
Minimal change disease (MCD) is a common pathological type of nephrotic syndrome in children and adults, the mechanisms remain obscure. The diagnosis MCD still relies on renal biopsy, lacking effective biological markers. This study explores diagnostic value circulating anti-nephrin antibody patients evaluates correlation with activity indicators such as proteinuria. included 108 adult glomerular disease, including 36 MCD, 16 primary focal segmental glomerulosclerosis (FSGS), 20 membranous...
Abstract The limited replicability of retention data hinders its application in untargeted metabolomics for small molecule identification. While order models hold promise addressing this issue, their predictive reliability is by uncertain generalizability. Here, we present the ROASMI model, which enables reliable prediction within a well-defined domain coupling data-driven molecular representation and mechanistic insights. generalizability proven 71 independent reversed-phase liquid...