A5100406170- Circular RNAs in diseases
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Corneal surgery and disorders
- Epigenetics and DNA Methylation
- IL-33, ST2, and ILC Pathways
- RNA modifications and cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory viral infections research
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Pancreatitis Pathology and Treatment
- Bacterial Identification and Susceptibility Testing
- Ophthalmology and Visual Impairment Studies
- Asthma and respiratory diseases
- Cancer-related gene regulation
- COVID-19 Clinical Research Studies
- Invertebrate Immune Response Mechanisms
- Pancreatic and Hepatic Oncology Research
- Congenital heart defects research
- Sepsis Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Peptidase Inhibition and Analysis
- Glaucoma and retinal disorders
Mayo Clinic
2024-2025
Sun Yat-sen University
2009-2025
Fujian Medical University
2022-2025
Mayo Clinic in Arizona
2023-2025
WinnMed
2025
The Seventh Affiliated Hospital of Sun Yat-sen University
2020-2025
Renji Hospital
2025
Union Hospital
2025
National Clinical Research Center for Digestive Diseases
2022-2024
Peking University
2018-2024
An ideal wound dressing for full-thickness regeneration should offer desirable biocompatibility, adequate mechanical properties, barrier function, and cellular regulation. Here, a bilayer scaffold resembling the hierarchical structure of human skin was developed using silk fibroin sodium alginate. The upper membrane prepared through casting functioned as epidermis, whereas lower porous by freeze-drying mimicked extracellular matrix structures. had nonporous structure, moderate hydrophilic...
Abstract Clinical hyperthermic intraperitoneal chemotherapy (HIPEC) is regarded as a potential treatment that can prolong survival of patients with peritoneal metastases after cytoreductive surgery. However, treated tumor cells are prone to becoming heat resistant HIPEC therapy through high expression shock proteins (HSPs). Here, carrier-free bifunctional nanoinhibitor was developed for in the management metastases. Self-assembly formed by mixing Mn ion and epigallocatechin gallate (EGCG)...
The Y-box-binding proteins (YBX) act as a multifunctional role in tumor progression, metastasis, drug resistance by regulating the transcription and translation process. Nevertheless, their functions pan-cancer setting remain unclear. This study examined clinical features expression, prognostic value, mutations, along with methylation patterns of three genes from YBX family (YBX1, YBX2, YBX3) 28 different types cancer. Data used for analysis were obtained Cancer Genome Atlas (TCGA)...
Chronic pancreatitis (CP) is a progressive and irreversible fibroinflammatory disorder, accompanied by pancreatic exocrine insufficiency dysregulated gut microbiota. Recently, accumulating evidence has supported correlation between dysbiosis CP development. However, whether microbiota contributes to pathogenesis remains unclear. Herein, an experimental was induced repeated high-dose caerulein injections. The broad-spectrum antibiotics (ABX) ABX targeting Gram-positive (G+) or Gram-negative...
Proapoptotic tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling as a cause of cancer cell death is well-established mechanism. However, TRAIL-receptor (TRAIL-R) agonists have had very limited anticancer activity in human beings, challenging the concept TRAIL potent agent. Herein, we aimed to define mechanisms by which TRAIL+ cells can leverage noncanonical myeloid-derived suppressor (MDSCs) promoting their abundance murine cholangiocarcinoma (CCA). Multiple...
•Transposase-mediated transduction of Fbxw7ΔF and Akt into the biliary epithelium promotes CCA carcinogenesis.•Murine cells derived from Fbxw7ΔF/Akt tumors can be implanted orthotopically mouse livers to generate a syngeneic model (FAC).•This recapitulates critical phenotypic pathological elements human iCCA.•Syngeneic murine models with different genetic drivers correspond subsets CCA.•Syngeneic iCCA display genotype-immune microenvironment phenotype correlation differential responses...
Abstract Early identification of infection severity and organ dysfunction is crucial in improving outcomes patients with sepsis. We aimed to develop a new combination blood-based biomarkers that can early predict 28-day mortality sepsis or septic shock. enrolled 66 shock compared 14 the first 24 h after ICU admission. The serum levels interleukin-6 (IL-6) (median 217.6 vs. 4809.0 pg/ml, P = 0.001), lactate 2.4 6.3 mmol/L, 0.014), N-terminal prohormone brain natriuretic peptide (NT-proBNP)...
Abstract Background: To evaluate the additive effects of orthokeratology (OK) lenses and 0.01% atropine on slowing axial elongation in myopic children. Methods: A prospective, randomized, double-blinded, placebo-controlled trial was conducted over a 12-month period. Sixty children aged 8 to 12 years with spherical equivalent refraction from − 1.00 -4.00 D who had been wearing OK successfully for 2 months (as baseline) were randomly assigned 1:1 ratio combination group (combination lens eye...
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA Abbreviation: BTC, biliary tract cancer. Correspondence Binbin Li, 200 1st St SW, MN 55905. Email: [email protected]
Minimal change disease (MCD) is a common pathological type of nephrotic syndrome in children and adults, the mechanisms remain obscure. The diagnosis MCD still relies on renal biopsy, lacking effective biological markers. This study explores diagnostic value circulating anti-nephrin antibody patients evaluates correlation with activity indicators such as proteinuria. included 108 adult glomerular disease, including 36 MCD, 16 primary focal segmental glomerulosclerosis (FSGS), 20 membranous...
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN Correspondence Sumera I. Ilyas, Assistant Professor Immunology Medicine, Clinic - 200 First Street SW , Minnesota 55905. Email: [email protected]
Objective To investigate if fibroblast growth factor 18 (FGF18) expression plays an important role in endometrial carcinoma (EC). Methods The clinicopathological associations and prognostic value of FGF18 were retrospectively analyzed 190 patients with EC. was stably knocked down EC cell lines. Changes proliferation, migration, invasion rates examined via behavior experiments. Tumor investigated using a xenograft mouse model. RNA sequencing (RNA-seq) performed to identify differentially...
Abstract Amino acids play significant roles in the study of life sciences, pharmaceutical R&D, bioengineering, and so on. Artificial amino acid‐based drugs are important advancing therapeutic innovation for multiple diseases including chronic pain, diabetes, Alzheimer's disease. On other hand, multicomponent reactions (MCRs) demonstrated to be a powerful strategy construction complicated structures from readily accessible starting reagents one pot. Thus, applying preparation their...
Low glutathione levels are associated with crystallin oxidation in age-related nuclear cataract. To understand the role of cysteine residue oxidation, we used novel approach comparing human cataracts glutathione-depleted LEGSKO mouse lenses for intra- versus intermolecular disulfide crosslinks using 2D-PAGE and proteomics, then systematically identified vivo vitro all forming sites ICAT labeling method coupled proteomics. Crystallins rich intramolecular disulfides were abundant at young age...
Age-related cataractogenesis is associated with disulfide-linked high molecular weight (HMW) crystallin aggregates. We recently found that the lens disulfidome was evolutionarily conserved in human and glutathione-depleted mouse (LEGSKO) cataracts it could be mimicked by oxidation vitro (Mol. Cell Proteomics, 14, 3211-23 (2015)). To obtain a comprehensive blueprint of oxidized key regulatory cytoskeletal proteins underlying cataractogenesis, we have now used same approach to determine,...
The function of activating transcription factor 1 (ATF1) and the mechanism about why ATF1 was over-phosphorylated in nasopharyngeal carcinoma (NPC) progression is completely undiscovered. In this study, a series experiments both vitro vivo were used to characterize promotive NPC tumorigenesis identify prolyl isomerase Pin1 as novel regulator at post-transcription. First, we found that overexpression promoted colony formation NPC. However, high protein level not resulted from mRNA level....
Abstract Background Respiratory syncytial virus (RSV) is an important cause of medically attended acute respiratory illnesses in older adults but awareness the relevance RSV people remains lower than that influenza, which exhibits similar clinical characteristics to those RSV. Objectives This study was performed assess significance samples from hospitalized adults. Methods Characteristics and outcomes (≥18 years) for infection (n = 51) were compared with a cohort influenza A 279)...
The global outbreak of the coronavirus disease 2019 (COVID-19) pandemic occurred in late and early 2020. factors that influence severity should be clinical concern. Existing findings on effects smoking COVID-19 are also controversial need to confirmed by further research. In addition, alcohol consumption betel quid (BQ) chewing unclear. aim this study was examine demographic characteristics patients smoking, drinking, BQ chewing, underlying diseases COVID-19. A retrospective conducted 91...
In shrimp, several glutathione peroxidase (GPX) genes have been cloned and functionally studied. Increasing evidence suggests the genes' involvement in white spot syndrome virus (WSSV)- or Vibrio alginolyticus-infection resistance. present study, a novel GXP gene (LvGPX3) was Litopenaeus vannamei. Promoter of LvGPX3 activated by NF-E2-related factor 2. Further study showed that expression evidently accelerated oxidative stress WSSV V. alginolyticus infection. Consistently, downregulated...
BACKGROUND:The incidence of liver fibrosis remains high due to the lack effective therapies. Our previous work found that microRNA (miR)-34a expression was increased, while acy1-CoA synthetase long-chain family member1 (ACSL1) decreased, in a dimethylnitrosamine (DNS)-induced hepatic rat model. We hypothesized miR-34a may play role process by targeting ACSL1. MATERIAL AND METHODS:From days 2 14, cultured primary stellate cells (HSCs) underwent cell morphology, immunocytochemical staining,...